TOP TEN perturbations for 1023_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1023_at
Selected probe(set): 207257_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1023_at (207257_at) across 6672 perturbations tested by GENEVESTIGATOR:

omeprazole study 6 (600uM) / vehicle (DMSO) treated hepatocyte sample

Relative Expression (log2-ratio):-2.4616852
Number of Samples:2 / 2
Experimental omeprazole study 6 (600uM)
Hepatocytes treated with compound: omeprazole (600uM; CHEMBL1503) for 24 hours. ATC code:
Control vehicle (DMSO) treated hepatocyte sample
Hepatocytes treated with vehicle (DMSO) for 24 hours.

ethionine study 3 (10000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):-2.370718
Number of Samples:2 / 2
Experimental ethionine study 3 (10000uM)
Hepatocytes treated with compound: ethionine (10000uM; CHEMBL203187) for 24 hours. ATC code:---
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

diclofenac study 5 (400uM) / vehicle (DMSO) treated hepatocyte sample

Relative Expression (log2-ratio):-2.326563
Number of Samples:2 / 2
Experimental diclofenac study 5 (400uM)
Hepatocytes treated with compound: diclofenac (400uM; CHEMBL139) for 24 hours. ATC code:, ,
Control vehicle (DMSO) treated hepatocyte sample
Hepatocytes treated with vehicle (DMSO) for 24 hours.

diclofenac study 6 (55uM) / vehicle (PBS) treated HepG2 sample

Relative Expression (log2-ratio):-2.2517786
Number of Samples:3 / 12
Experimental diclofenac study 6 (55uM)
HepG2 cells treated with compound: diclofenac (55uM; CAS no.:15307-86-5) for 24 hours. Diclofenac is hepatotoxic and may cause necrosis. HepG2 cells were treated with the IC20 concentration measured after 24 hours. ATC code:, ,
Control vehicle (PBS) treated HepG2 sample
HepG2 cells treated with PBS (0.5% v/v) as solvent control for 24 hours.

methapyrilene study 6 (600uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):-2.217825
Number of Samples:2 / 2
Experimental methapyrilene study 6 (600uM)
Hepatocytes treated with compound: methapyrilene (600uM; CHEMBL1411979) for 24 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

paracetamol (acetaminophen) study 6 (5000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):-2.1900463
Number of Samples:2 / 2
Experimental paracetamol (acetaminophen) study 6 (5000uM)
Hepatocytes treated with compound: acetaminophen (5000uM; CHEMBL112) for 24 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

allyl alcohol study 3 (70uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):-2.1599646
Number of Samples:2 / 2
Experimental allyl alcohol study 3 (70uM)
Hepatocytes treated with compound: allyl alcohol (70uM; CHEMBL234926) for 24 hours. ATC code:---
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

IQ study 1 (24h) / vehicle (DMSO) treated HepG2 cell sample

Relative Expression (log2-ratio):-2.0749884
Number of Samples:2 / 7
Experimental IQ study 1 (24h)
HepG2 cells exposed to 800μM 2-amino-3-methylimidazo[4,5-f] quinolone (IQ) in DMSO solvent for 24 hours. ATC code:---
Control vehicle (DMSO) treated HepG2 cell sample
HepG2 cells exposed to DMSO solvent for 24 hours.

paracetamol (acetaminophen) study 7 (10000uM) / vehicle (DMSO) treated HepG2 sample

Relative Expression (log2-ratio):-2.0334206
Number of Samples:3 / 21
Experimental paracetamol (acetaminophen) study 7 (10000uM)
HepG2 cells treated with compound: paracetamol (10000uM; CAS no.:103-90-2) for 24 hours. Paracetamol is hepatotoxic and may cause necrosis. HepG2 cells were treated with the IC20 concentration measured after 24 hours. ATC code:
Control vehicle (DMSO) treated HepG2 sample
HepG2 cells treated with DMSO (0.5% v/v) as solvent control for 24 hours.

ovarian tumor study 16 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):2.0015755
Number of Samples:3 / 5
Experimental ovarian tumor study 16
Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue.