TOP TEN perturbations for 1080_s_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1080_s_at
Selected probe(set): 207608_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1080_s_at (207608_x_at) across 6673 perturbations tested by GENEVESTIGATOR:

omeprazole study 6 (120uM) / vehicle (DMSO) treated hepatocyte sample

Relative Expression (log2-ratio):5.4662857
Number of Samples:2 / 2
Experimental omeprazole study 6 (120uM)
Hepatocytes treated with compound: omeprazole (120uM; CHEMBL1503) for 24 hours. ATC code:
Control vehicle (DMSO) treated hepatocyte sample
Hepatocytes treated with vehicle (DMSO) for 24 hours.

hepatoblastoma study 1 (epithelial mixed) / normal liver tissue

Relative Expression (log2-ratio):-5.386451
Number of Samples:12 / 5
Experimental hepatoblastoma study 1 (epithelial mixed)
Liver tumor tissue samples from children with hepatoblastoma (epithelial type (E-HB); epithelial mixed subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.

omeprazole study 6 (24uM) / vehicle (DMSO) treated hepatocyte sample

Relative Expression (log2-ratio):5.369087
Number of Samples:2 / 2
Experimental omeprazole study 6 (24uM)
Hepatocytes treated with compound: omeprazole (24uM; CHEMBL1503) for 24 hours. ATC code:
Control vehicle (DMSO) treated hepatocyte sample
Hepatocytes treated with vehicle (DMSO) for 24 hours.

HCC study 23 (portal vein infiltration) / adjacent liver tissue

Relative Expression (log2-ratio):-5.1917076
Number of Samples:3 / 10
Experimental HCC study 23 (portal vein infiltration)
Tumor liver tissue samples derived from patients with hepatocellular carcinoma (HCC) with portal vein infiltration. Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai.
Control adjacent liver tissue
Normal adjacent liver tissue samples derived from patients with hepatocellular carcinoma (HCC). Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai.

HCC study 9 (HBV; HCV) / normal liver tissue

Relative Expression (log2-ratio):-5.180706
Number of Samples:2 / 10
Experimental HCC study 9 (HBV; HCV)
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

HCC study 27 (young; training) / normal liver tissue (young; training)

Relative Expression (log2-ratio):-5.1799936
Number of Samples:16 / 15
Experimental HCC study 27 (young; training)
Primary tumor tissue samples obtained from the liver of young patients (≤ 40 years old) with hepatocellular carcinoma assigned to a training cohort.
Control normal liver tissue (young; training)
Normal liver tissue samples obtained from young patients (≤ 40 years old) with hepatocellular carcinoma (HCC) assigned to a training cohort.

hepatoblastoma study 1 (NOS) / normal liver tissue

Relative Expression (log2-ratio):-5.158655
Number of Samples:5 / 5
Experimental hepatoblastoma study 1 (NOS)
Liver tumor tissue samples from children with hepatoblastoma (NOS). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.

hepatoblastoma study 1 (embryonal) / normal liver tissue

Relative Expression (log2-ratio):-5.147998
Number of Samples:7 / 5
Experimental hepatoblastoma study 1 (embryonal)
Liver tumor tissue samples from children with hepatoblastoma (epithelial type (E-HB); embryonal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.

hexachlorobenzene study 3 (30uM) / vehicle (DMSO) treated hepatocyte sample

Relative Expression (log2-ratio):4.9850616
Number of Samples:2 / 2
Experimental hexachlorobenzene study 3 (30uM)
Hepatocytes treated with compound: hexachlorobenzene (30uM; CHEMBL228514) for 24 hours. ATC code:---
Control vehicle (DMSO) treated hepatocyte sample
Hepatocytes treated with vehicle (DMSO) for 24 hours.

hepatoblastoma study 1 (mixed epithelial and mesenchymal) / normal liver tissue

Relative Expression (log2-ratio):-4.848343
Number of Samples:4 / 5
Experimental hepatoblastoma study 1 (mixed epithelial and mesenchymal)
Liver tumor tissue samples from children with hepatoblastoma (mesenchymal type (MEM-HB); mixed epithelial and mesenchymal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.