TOP TEN perturbations for 1123_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1123_at
Selected probe(set): 211544_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1123_at (211544_s_at) across 6672 perturbations tested by GENEVESTIGATOR:

null cell adenoma study 1 / normal pituitary gland tissue

Relative Expression (log2-ratio):-6.5050316
Number of Samples:2 / 8
Experimental null cell adenoma study 1
Null cell adenoma biopsy samples recovered during transsphenoidal surgery. The tumors were defined by gonadotropic staining for FSH, LH, or alpha subunit in less than 5-10% of cells. Samples were scanned between 04/6/2004 - 15/4/2005.
Control normal pituitary gland tissue
Biopsy samples of healthy pituitary gland recovered post-mortem during autopsy within 2-18 hours of death. Cause of death were mostly various pulmonary or cardiovascular conditions.

gonadotroph adenoma study 1 / normal pituitary gland tissue

Relative Expression (log2-ratio):-5.7892504
Number of Samples:7 / 8
Experimental gonadotroph adenoma study 1
Gonadotroph adenoma biopsy samples recovered during transsphenoidal surgery. The tumors were defined as demonstrating positive immunostaining for FSH, LH, or alpha subunit in greater than 5-10% of cells. Samples were scanned between 04/6/2004 - 15/4/2005.
Control normal pituitary gland tissue
Biopsy samples of healthy pituitary gland recovered post-mortem during autopsy within 2-18 hours of death. Cause of death were mostly various pulmonary or cardiovascular conditions.

brefeldin A study 1 (0.5ug/ml; p53HCT116) / untreated p53HCT116 cell sample

Relative Expression (log2-ratio):-1.0387592
Number of Samples:2 / 3
Experimental brefeldin A study 1 (0.5ug/ml; p53HCT116)
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:---
Control untreated p53HCT116 cell sample
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS.

LPS study 4 (shRNA cycT1) / cycT1 depletion study 2 (shRNA)

Relative Expression (log2-ratio):-0.8639469
Number of Samples:2 / 2
Experimental LPS study 4 (shRNA cycT1)
MONO-MAC-6 (MM6) cells were transduced with shRNA against cyclin T1 and then treated with 10 ng/ml lipopolysaccharide (LPS). ATC code:---
Control cycT1 depletion study 2 (shRNA)
MONO-MAC-6 (MM6) cells were transduced with shRNA against cyclin T1 and then mock treated.

multiple myeloma study 3 (secondary) / MGUS study 1

Relative Expression (log2-ratio):0.8349638
Number of Samples:2 / 3
Experimental multiple myeloma study 3 (secondary)
Plasma cell (PC) samples from patients with secondary multiple myeloma (SMM).
Control MGUS study 1
Plasma cell (PC) samples from patients with monoclonal gammopathy of undetermined significance (MGUS).

Alzheimer's disease study 7 / normal pyramidal neuron (hippocampus)

Relative Expression (log2-ratio):0.79057693
Number of Samples:10 / 12
Experimental Alzheimer's disease study 7
Pyramidal neurons collected from the CA1 region of the hippocampus of clinically and neuropathologically classified late-onset Alzheimer┬┤s disease afflicted individuals. Subjects in this group had a Braak stage of V or VI with a CERAD score of moderate or frequent.
Control normal pyramidal neuron (hippocampus)
Pyramidal neurons collected from the CA1 region of the hippocampus of clinically classified as neurologically normal individuals. Subjects in this group had a Braak stage ranging from I to II with a infrequent Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuritic plaque density.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-0.77094936
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

glioma study 16 (glioblastoma) / normal brain tissue

Relative Expression (log2-ratio):-0.7673912
Number of Samples:12 / 2
Experimental glioma study 16 (glioblastoma)
Primary glioma tissues obtained from the operating room. Tumors were diagnosed and graded according to the current WHO classification (grade IV).
Control normal brain tissue
Normal brain tissue sample from healthy donors.

focal segmental glomerulosclerosis study 9 (glomerulus) / tumor adjacent glomerular tissue

Relative Expression (log2-ratio):-0.75404835
Number of Samples:10 / 3
Experimental focal segmental glomerulosclerosis study 9 (glomerulus)
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control tumor adjacent glomerular tissue
Normal renal glomerular tissue adjacent to tumor. Samples were obtained during tumor nephrectomy. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.

Parkinson's disease study 5 / normal pars compacta tissue

Relative Expression (log2-ratio):0.732028
Number of Samples:2 / 5
Experimental Parkinson's disease study 5
Pars compacta tissue from patients with Parkinson's disease.
Control normal pars compacta tissue
Normal pars compacta tissue.