TOP TEN perturbations for 1130_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1130_at
Selected probe(set): 202670_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1130_at (202670_at) across 6593 perturbations tested by GENEVESTIGATOR:
CNS cancer study 1 (PDX; glioma, malignant, NOS; primary) / CNS cancer study 1 (PDX; ependymoma, NOS; primary)
Relative Expression (log2-ratio):3.4007664Number of Samples:2 / 2
| Experimental | CNS cancer study 1 (PDX; glioma, malignant, NOS; primary) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioma, malignant, NOS of the central nervous system (subcutaneously implanted). | |
| Control | CNS cancer study 1 (PDX; ependymoma, NOS; primary) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary ependymoma, NOS of the central nervous system (subcutaneously implanted). |
CNS cancer study 1 (PDX; glioma, malignant, NOS; primary) / CNS cancer study 1 (PDX; glioblastoma, NOS; primary)
Relative Expression (log2-ratio):3.0835695Number of Samples:2 / 3
| Experimental | CNS cancer study 1 (PDX; glioma, malignant, NOS; primary) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioma, malignant, NOS of the central nervous system (subcutaneously implanted). | |
| Control | CNS cancer study 1 (PDX; glioblastoma, NOS; primary) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioblastoma, NOS of the central nervous system (subcutaneously implanted). |
vMyb overexpr. study 1 (adenovirus) / cMyb overexpr. study 2 (adenovirus)
Relative Expression (log2-ratio):-2.8323765Number of Samples:2 / 2
| Experimental | vMyb overexpr. study 1 (adenovirus) |
| Approximately 1x10^6 monocytes were infected with adenovirus expressing v-Myb and GFP for 16 hours, then total RNA was isolated. | |
| Control | cMyb overexpr. study 2 (adenovirus) |
| Approximately 1x10^6 monocytes were infected with adenovirus expressing c-Myb and GFP for 16 hours, then total RNA was isolated. |
endothelin 1 study 1 / normal iPSC-derived cardiomyocyte sample
Relative Expression (log2-ratio):2.8313885Number of Samples:3 / 3
| Experimental | endothelin 1 study 1 |
| Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) treated with 10nM endothelin 1 (ET-1) for 18hours. These cardiomyocytes are a highly pure ventricular population established as having functional properties similar to adult human cardiomyocytes. All iPSC-CMs were obtained from one single batch of cells. After two days of recovery, the cells were cultured in William’s E medium supplemented with Cocktail B (1:25) from the Hepatocyte Maintenance Supplement Pack. After an additional 11 days of recovery, cells were stimulated for 18 h with 10nM ET-1. ET-1 is a potent vasoconstrictor and a well established modulator of cardiac hypertrophy in humans. ATC code:--- | |
| Control | normal iPSC-derived cardiomyocyte sample |
| Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs). These cardiomyocytes are a highly pure ventricular population established as having functional properties similar to adult human cardiomyocytes. All iPSC-CMs were obtained from one single batch of cells. The cells were cultured in William’s E medium supplemented with Cocktail B (1:25) from the Hepatocyte Maintenance Supplement Pack. |
expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (clear cell adenocarcinoma, NOS; metastatic)
Relative Expression (log2-ratio):2.5632935Number of Samples:2 / 4
| Experimental | expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary. | |
| Control | expO ovary cancer study 1 (clear cell adenocarcinoma, NOS; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary clear cell adenocarcinoma (NOS) of the ovary. |
expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (adenocarcinoma, NOS; metastatic)
Relative Expression (log2-ratio):2.4118605Number of Samples:2 / 7
| Experimental | expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary. | |
| Control | expO ovary cancer study 1 (adenocarcinoma, NOS; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary adenocarcinoma (NOS) of the ovary. |
HCC study 24 (metastatic) / adjacent liver tissue
Relative Expression (log2-ratio):-2.3173037Number of Samples:7 / 2
| Experimental | HCC study 24 (metastatic) |
| Metastatic tumor liver tissue samples derived from patients with intrahepatic metastatic hepatocellular carcinoma (HCC). Samples were obtained from patients who underwent primary HCC curative hepatic resection at TaipeiVeterans General Hospital in Taiwan. | |
| Control | adjacent liver tissue |
| Normal adjacent liver tissue samples derived from patients with hepatocellular carcinoma (HCC). Samples were obtained from patients who underwent primary HCC curative hepatic resection at TaipeiVeterans General Hospital in Taiwan. |
expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (endometrioid carcinoma; metastatic)
Relative Expression (log2-ratio):2.2232018Number of Samples:2 / 3
| Experimental | expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary. | |
| Control | expO ovary cancer study 1 (endometrioid carcinoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary endometrioid carcinoma of the ovary. |
expO ovary cancer study 1 (papillary serous cystadenocarcinoma; metastatic) / expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic)
Relative Expression (log2-ratio):-2.1592646Number of Samples:51 / 2
| Experimental | expO ovary cancer study 1 (papillary serous cystadenocarcinoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary papillary serous cystadenocarcinoma of the ovary. | |
| Control | expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary. |
wound healing study 2 (ex vivo; DMSO) / normal skin tissue (ex vivo)
Relative Expression (log2-ratio):2.1535492Number of Samples:3 / 3
| Experimental | wound healing study 2 (ex vivo; DMSO) |
| Ex vivo skin samples obtained from healthy donors following reduction surgery of abdomen, and incubated in culture medium containing DMSO for 4 days. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. Skin was sliced into 1x10 mm slices and incubated in keratinocyte medium for four days with 1:1000 fold dilution of DMSO. The cultivation was performed in serum-free keratinocyte medium supplemented with transferrin, hEGF (0.15 ng/mL), 0.5 mg/mL hydrocortisone, gentamicin, amphotericin B, and epinephrine but without insulin. | |
| Control | normal skin tissue (ex vivo) |
| Normal skin samples obtained from healthy donors following reduction surgery of abdomen. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. |