TOP TEN perturbations for 1131_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1131_at
Selected probe(set): 202424_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1131_at (202424_at) across 6622 perturbations tested by GENEVESTIGATOR:

oncolytic herpes simplex virus study 2 / mock infected peripheral nerve sheath tumor (S462) cell sample

Relative Expression (log2-ratio):-3.1078625
Number of Samples:3 / 3
Experimental oncolytic herpes simplex virus study 2
Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours.
Control mock infected peripheral nerve sheath tumor (S462) cell sample
Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours.

ovarian tumor study 11 (low grade) / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):2.300147
Number of Samples:11 / 6
Experimental ovarian tumor study 11 (low grade)
Human microdissected tumor cells from the ovary of patients with low grade serous carcinoma.
Control normal ovarian surface epithelial cell sample
Human microdissected ovarian surface epithelial cell sample from the ovary of healthy individuals.

glioma study 17 (glioblastoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):2.2321644
Number of Samples:3 / 3
Experimental glioma study 17 (glioblastoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from high grade glioblastoma (grade IV). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 66 ± 5 years old males.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

glioma study 17 (anaplastic astrocytoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):2.1582785
Number of Samples:2 / 3
Experimental glioma study 17 (anaplastic astrocytoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from high grade anaplastic astrocytoma (grade III). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 45 ± 18 years old.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

MAP2K2 depletion study 1 / mock transfected SW-480 cell sample

Relative Expression (log2-ratio):-2.1089106
Number of Samples:6 / 6
Experimental MAP2K2 depletion study 1
RNAi-mediated gene knockdown of MAP2K2 in colorectal cancer cell line SW-480.
Control mock transfected SW-480 cell sample
SW-480 colorectal cell line sample transduced with non-targeting pLKO_NonTarget vector.

glioma study 16 (LN-215) / normal astrocyte sample

Relative Expression (log2-ratio):2.0886002
Number of Samples:2 / 3
Experimental glioma study 16 (LN-215)
Human glioma cell line LN215 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

MAP2K2 depletion study 2 / control vector transfected SW-620 cell sample

Relative Expression (log2-ratio):-2.0039062
Number of Samples:6 / 6
Experimental MAP2K2 depletion study 2
RNAi-mediated gene knockdown of MAP2K2 in colorectal cancer cell line SW-620.
Control control vector transfected SW-620 cell sample
SW-620 colorectal cell line sample transduced with empty vector pLKO.

MAP2K2 depletion study 1 / normal SW-480 cell sample

Relative Expression (log2-ratio):-1.9921017
Number of Samples:6 / 3
Experimental MAP2K2 depletion study 1
RNAi-mediated gene knockdown of MAP2K2 in colorectal cancer cell line SW-480.
Control normal SW-480 cell sample
Non-transduced SW-480 colorectal cell line sample.

MAP2K2 depletion study 1 / control vector transfected SW-480 cell sample

Relative Expression (log2-ratio):-1.9850245
Number of Samples:6 / 6
Experimental MAP2K2 depletion study 1
RNAi-mediated gene knockdown of MAP2K2 in colorectal cancer cell line SW-480.
Control control vector transfected SW-480 cell sample
SW-480 colorectal cell line sample transduced with empty vector pLKO.

MAP2K2 depletion study 2 / normal SW-620 cell sample

Relative Expression (log2-ratio):-1.9401112
Number of Samples:6 / 3
Experimental MAP2K2 depletion study 2
RNAi-mediated gene knockdown of MAP2K2 in colorectal cancer cell line SW-620.
Control normal SW-620 cell sample
Non-transduced SW-620 colorectal cell line sample.