TOP TEN perturbations for 11759697_at (Homo sapiens)

Organism: Homo sapiens
Gene: 11759697_at
Selected probe(set): 206732_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 11759697_at (206732_at) across 5880 perturbations tested by GENEVESTIGATOR:

glioma study 17 (small cell glioblastoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):-4.5744467
Number of Samples:2 / 3
Experimental glioma study 17 (small cell glioblastoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from high grade small cell glioblastoma (grade IV). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 56 ± 3 years old males.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

stem cell differentiation study 41 (T3pi) / stem cell differentiation study 41 (hES-T3 EB)

Relative Expression (log2-ratio):3.8842268
Number of Samples:2 / 2
Experimental stem cell differentiation study 41 (T3pi)
Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype.
Control stem cell differentiation study 41 (hES-T3 EB)
Sample of embryonic bodies (EB) differentiated from human embryonic stem cells T3 with female karyotype.

oligodendrocyte progenitor cell study 2 (O4-;CD140a+) / oligodendrocyte progenitor cell study 2 (O4-;CD140a-)

Relative Expression (log2-ratio):3.790491
Number of Samples:5 / 5
Experimental oligodendrocyte progenitor cell study 2 (O4-;CD140a+)
Fetal oligodendrocyte cells between 20-22wk gestational age derived from fetal brains were FACS sorted on the basis of CD140a (PDGFRA) antigens. Samples were O4-/CD140a+.
Control oligodendrocyte progenitor cell study 2 (O4-;CD140a-)
Fetal oligodendrocyte cells between 20-22wk gestational age derived from fetal brains were FACS sorted on the basis of CD140a (PDGFRA) antigens. Samples were O4-/CD140a-.

glioma study 17 (anaplastic astrocytoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):-3.6560545
Number of Samples:2 / 3
Experimental glioma study 17 (anaplastic astrocytoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from high grade anaplastic astrocytoma (grade III). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 45 ± 18 years old.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (ependymoma)

Relative Expression (log2-ratio):3.6008978
Number of Samples:15 / 46
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control brain tumor study 1 (ependymoma)
Primary tumor tissue sample from the brain of patients with ependymoma.

stem cell differentiation study 41 (T3pi) / undifferentiated hES-T3 cell sample

Relative Expression (log2-ratio):3.5396461
Number of Samples:2 / 3
Experimental stem cell differentiation study 41 (T3pi)
Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype.
Control undifferentiated hES-T3 cell sample
Undifferentiated human embryonic stem cells T3.

brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (medulloblastoma)

Relative Expression (log2-ratio):2.9561005
Number of Samples:15 / 22
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.

HIV-associated neurocognitive disorder study 7 (normal) / HIV-associated neurocognitive disorder study 6 (normal)

Relative Expression (log2-ratio):2.7533188
Number of Samples:2 / 2
Experimental HIV-associated neurocognitive disorder study 7 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients received antiretroviral therapy (ART).
Control HIV-associated neurocognitive disorder study 6 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients did not receive any antiretroviral therapy (ART).

brain tumor study 1 (ependymoma) / normal brain tissue

Relative Expression (log2-ratio):-2.7332363
Number of Samples:46 / 12
Experimental brain tumor study 1 (ependymoma)
Primary tumor tissue sample from the brain of patients with ependymoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

medulloblastoma study 1 / non-tumor brain tissue

Relative Expression (log2-ratio):-2.6841478
Number of Samples:17 / 9
Experimental medulloblastoma study 1
Primary tumor tissue sample from the infratentorial brain of pediatric patients with classical medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.