TOP TEN perturbations for 1178_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1178_at
Selected probe(set): 202534_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1178_at (202534_x_at) across 6672 perturbations tested by GENEVESTIGATOR:

ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary) / ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-4.49255
Number of Samples:2 / 2
Experimental ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary mixed tumor, malignant, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the ovary (subcutaneously implanted).

ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; primary) / ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary)

Relative Expression (log2-ratio):3.4136448
Number of Samples:13 / 2
Experimental ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary serous cystadenocarcinoma, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary mixed tumor, malignant, NOS of the ovary (subcutaneously implanted).

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone study 1 (7500 uM; HepaRG) / vehicle (DMSO) treated HepaRG cell sample

Relative Expression (log2-ratio):-3.2898083
Number of Samples:3 / 12
Experimental 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone study 1 (7500 uM; HepaRG)
HepaRG cells exposed to 7500 uM 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (dissolved in 0.5% v/v DMSO) for 72 hours. Cells were cultivated in DMSO-containing medium between days 13 - 19 to allow them to differentiate into hepatocyte-like cells and become fully functional. Chemical was added at day 19 of cultivation. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:---
Control vehicle (DMSO) treated HepaRG cell sample
HepaRG cells treated with vehicle (DMSO 0.5% v/v) for 72 hours. Firstly, cells were cultivated in DMSO-containing medium between days 13 - 19 to allow them to differentiate into hepatocyte-like cells and become fully functional. Then the vehicle was added.

ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary) / ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary)

Relative Expression (log2-ratio):3.2377815
Number of Samples:2 / 2
Experimental ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary transitional cell carcinoma, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary mixed tumor, malignant, NOS of the ovary (subcutaneously implanted).

PD-0332991 study 4 (G1 arrest) / medium treated bronchial epithelial cell sample

Relative Expression (log2-ratio):-3.1553097
Number of Samples:3 / 3
Experimental PD-0332991 study 4 (G1 arrest)
Bronchial epithelial cells (NHBE) treated with CDK4/6 inhibitor PD-0332991 (palbociclib) to arrest them in G1 phase for 8 hours. Therefore, cells were cultured in standard growth medium for 24 hours, followed by treatment with 1 μM PD-0332991 (non-toxic dose) for another 24 hours and then washed and treated with the same dose of PD-0332991 again for indicated timepoints. ATC code:---
Control medium treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) cultured in standard growth medium for 2 x 24 hours, followed by culture in growth medium for another 8 hours.

PD-0332991 study 1 (G1 arrest) / medium treated bronchial epithelial cell sample

Relative Expression (log2-ratio):-3.1199093
Number of Samples:3 / 3
Experimental PD-0332991 study 1 (G1 arrest)
Bronchial epithelial cells (NHBE) treated with CDK4/6 inhibitor PD-0332991 (palbociclib) to arrest them in G1 phase for 2 hours. Therefore, cells were cultured in standard growth medium for 24 hours, followed by treatment with 1 μM PD-0332991 (non-toxic dose) for another 24 hours and then washed and treated with the same dose of PD-0332991 again for indicated timepoints. ATC code:---
Control medium treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) cultured in standard growth medium for 2 x 24 hours, followed by culture in growth medium for another 2 hours.

PD-0332991 study 3 (G1 arrest) / medium treated bronchial epithelial cell sample

Relative Expression (log2-ratio):-3.1145363
Number of Samples:3 / 3
Experimental PD-0332991 study 3 (G1 arrest)
Bronchial epithelial cells (NHBE) treated with CDK4/6 inhibitor PD-0332991 (palbociclib) to arrest them in G1 phase for 6 hours. Therefore, cells were cultured in standard growth medium for 24 hours, followed by treatment with 1 μM PD-0332991 (non-toxic dose) for another 24 hours and then washed and treated with the same dose of PD-0332991 again for indicated timepoints. ATC code:---
Control medium treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) cultured in standard growth medium for 2 x 24 hours, followed by culture in growth medium for another 6 hours.

PD-0332991 study 2 (G1 arrest) / medium treated bronchial epithelial cell sample

Relative Expression (log2-ratio):-3.039751
Number of Samples:3 / 3
Experimental PD-0332991 study 2 (G1 arrest)
Bronchial epithelial cells (NHBE) treated with CDK4/6 inhibitor PD-0332991 (palbociclib) to arrest them in G1 phase for 4 hours. Therefore, cells were cultured in standard growth medium for 24 hours, followed by treatment with 1 μM PD-0332991 (non-toxic dose) for another 24 hours and then washed and treated with the same dose of PD-0332991 again for indicated timepoints. ATC code:---
Control medium treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) cultured in standard growth medium for 2 x 24 hours, followed by culture in growth medium for another 4 hours.

T-cell activation study 4 / normal resting T-cell sample

Relative Expression (log2-ratio):2.9647255
Number of Samples:2 / 2
Experimental T-cell activation study 4
T-cell samples antiCD3 activated for 30hrs.
Control normal resting T-cell sample
T cells resting for 30h.

MCF-7.5C / MCF-7

Relative Expression (log2-ratio):2.963148
Number of Samples:3 / 4
Experimental MCF-7.5C
Human metastatic cancer cell line derived from the pleural effusion of a patient with adenocarcinoma of the breast. Long-term estrogen deprived breast cancer cells, which are resistant to estrogen-deprivation and therefore show an aromatase inhibitor resistantance. Parental cell line:: MCF-7 Synonyms:MCF-7 clone 5C; 5C; MCF-7:5C Cellosaurus code:
Control MCF-7
Human metastatic cancer cell line derived from the pleural effusion of a patient (69 years old, caucasian) with adenocarcinoma of the breast. Synonyms:MCF 7; MCF.7; MCF7; Michigan Cancer Foundation 7; ssMCF7; MCF7/WT; IBMF-7; MCF7-CTRL Cellosaurus code: