TOP TEN perturbations for 1257_s_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1257_s_at
Selected probe(set): 201482_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1257_s_at (201482_at) across 6674 perturbations tested by GENEVESTIGATOR:
hepatocyte (ESC) / HepaRG
Relative Expression (log2-ratio):3.318264Number of Samples:8 / 12
Experimental | hepatocyte (ESC) |
Hepatocyte-like cells differentiated from embryonic stem cells (ESC) | |
Control | HepaRG |
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code: |
CD44s overexpr. study 1 / normal HEK-293 cell sample
Relative Expression (log2-ratio):2.8495274Number of Samples:3 / 3
Experimental | CD44s overexpr. study 1 |
Human embryonic kidney cell line HEK-293 transfected with pcDNA3.1(-) vector containing codon-optimized human CD44 sequence for expression. | |
Control | normal HEK-293 cell sample |
Untransfected, native human embryonic kidney cell line HEK-293 cell samples. |
SDF study 4 / untreated MDA Mb231 cell sample
Relative Expression (log2-ratio):-2.5606823Number of Samples:3 / 6
Experimental | SDF study 4 |
MDA Mb231 cells treated with 75nM stromal derived factor (SDF; Cxcl12) for 6h. | |
Control | untreated MDA Mb231 cell sample |
Untreated MDA Mb231 cells harvested after 6h. |
B-cell activation study 1 / unstimulated B-cell sample
Relative Expression (log2-ratio):2.439828Number of Samples:4 / 4
Experimental | B-cell activation study 1 |
Tonsillar B-cell samples stimulated with 10 µg/mL anti-CD40 antibody and 100 U/mL recombinant human IL-4. Cells were cultured under TH2-skewing conditions for 24 hours. | |
Control | unstimulated B-cell sample |
Unstimulated tonsillar B-cells cultured for 24 hours. |
Barrett's esophagus study 3 / esophageal squamous cell carcinoma study 1
Relative Expression (log2-ratio):2.4287558Number of Samples:17 / 8
Experimental | Barrett's esophagus study 3 |
Esophageal epithelium samples from areas with Barrett's esophagus metaplasia which were recovered by laser capture microdissection. | |
Control | esophageal squamous cell carcinoma study 1 |
Esophageal squamous cell carcinoma (ESCC) biopsy samples from chemotherapy-naive patients with histological grading G1 (well differentiated) and UICC stage II and III, which undergone esophagectomy. |
Sjogren's syndrome study 1 (advanced) / normal minor salivary gland tissue
Relative Expression (log2-ratio):-2.3836384Number of Samples:2 / 4
Experimental | Sjogren's syndrome study 1 (advanced) |
Whole minor salivary gland samples of patients with advanced Sjogren's syndrome. | |
Control | normal minor salivary gland tissue |
Whole minor salivary gland samples from non-Sjogren's syndrome control subjects. |
precursor-B-ALL study 1 (t(12;21)(p12,q22)) / normal bone marrow sample
Relative Expression (log2-ratio):-2.2605858Number of Samples:58 / 74
Experimental | precursor-B-ALL study 1 (t(12;21)(p12,q22)) |
Bone marrow samples of patients with precursor B-ALL (t(12;21)(p12,q22)/TEL-AML1). | |
Control | normal bone marrow sample |
Non-leukemic and healthy bone marrow sample. |
esophageal squamous cell carcinoma study 1 / normal esophageal epithelium sample
Relative Expression (log2-ratio):-2.2569056Number of Samples:8 / 18
Experimental | esophageal squamous cell carcinoma study 1 |
Esophageal squamous cell carcinoma (ESCC) biopsy samples from chemotherapy-naive patients with histological grading G1 (well differentiated) and UICC stage II and III, which undergone esophagectomy. | |
Control | normal esophageal epithelium sample |
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy. |
house dust mite study 2 (allergic) / house dust mite study 2 (non-allergic)
Relative Expression (log2-ratio):2.203867Number of Samples:5 / 4
Experimental | house dust mite study 2 (allergic) |
Primary nasal epithelial cells from subjects with monotypical allergy to house dust mite (HDM) were exposed to house dust mite extract (2µg/ml) for 24 hours. Subjects (19-55 years old) were selected based on skin prick test for HDM and other common allergens. The subjects had refrained from using any medication for their allergy in the 4 weeks before the samples collection. Nasal biopsies for isolation of primary cells were taken from the lower edge of the inferior turbinate, and 2 cm from the anterior end. | |
Control | house dust mite study 2 (non-allergic) |
Primary nasal epithelial cells from healthy subjects with no allergies were exposed to house dust mite (HDM) extract (2µg/ml) for 24 hours. Subjects (21-32 years old) were selected based on skin prick test for HDM and other common allergens. Nasal biopsies for isolation of primary cells were taken from the lower edge of the inferior turbinate, and 2 cm from the anterior end. |
kidney transplantation study 15 (8 week) / normal monocyte (CD14+) sample
Relative Expression (log2-ratio):2.1975918Number of Samples:2 / 5
Experimental | kidney transplantation study 15 (8 week) |
CD14+ monocyte samples derived from kidney transplant patients 8 weeks post-transplantation. Samples were collected 8 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH). | |
Control | normal monocyte (CD14+) sample |
CD14+ monocyte samples derived from healthy control subjects. |