TOP TEN perturbations for 130_s_at (Homo sapiens)

Organism: Homo sapiens
Gene: 130_s_at
Selected probe(set): 211024_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 130_s_at (211024_s_at) across 6673 perturbations tested by GENEVESTIGATOR:

HCC827 / A-549

Relative Expression (log2-ratio):5.2268996
Number of Samples:6 / 6
Experimental HCC827
Human primary cancer cell line derived from the lung of a patient with non-small-cell lung cancer. Synonyms:HCC-827; HCC0827 Cellosaurus code:
Control A-549
Human primary cancer cell line derived from the lung of a patient with carcinoma. Synonyms:A 549; A549; NCI-A549; A549/ATCC; hA549 Cellosaurus code:

expO lung cancer study 1 (squamous cell carcinoma, NOS; primary) / expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-4.6674986
Number of Samples:40 / 2
Experimental expO lung cancer study 1 (squamous cell carcinoma, NOS; primary)
Primary tumor tissue samples obtained from the lung of patients with squamous cell carcinoma (NOS).
Control expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the lung of patients with papillary adenocarcinoma (NOS).

expO lung cancer study 1 (squamous cell carcinoma, NOS; metastatic) / expO lung cancer study 1 (non-small cell carcinoma; metastatic)

Relative Expression (log2-ratio):-4.4928026
Number of Samples:3 / 3
Experimental expO lung cancer study 1 (squamous cell carcinoma, NOS; metastatic)
Metastatic tumor tissue samples obtained from patients with primary squamous cell carcinoma (NOS) of the lung.
Control expO lung cancer study 1 (non-small cell carcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary non-small cell carcinoma of the lung.

expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO lung cancer study 1 (large cell carcinoma, NOS; primary)

Relative Expression (log2-ratio):4.3754673
Number of Samples:2 / 9
Experimental expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the lung of patients with papillary adenocarcinoma (NOS).
Control expO lung cancer study 1 (large cell carcinoma, NOS; primary)
Primary tumor tissue samples obtained from the lung of patients with large cell carcinoma (NOS).

prostate cancer study 1 (meta.) / benign prostate tissue

Relative Expression (log2-ratio):4.1664906
Number of Samples:6 / 6
Experimental prostate cancer study 1 (meta.)
Metastatic prostate cancer samples.
Control benign prostate tissue
Benign prostate samples.

prostate cancer study 1 (meta.) / prostate cancer study 1 (prim.)

Relative Expression (log2-ratio):4.0577173
Number of Samples:6 / 7
Experimental prostate cancer study 1 (meta.)
Metastatic prostate cancer samples.
Control prostate cancer study 1 (prim.)
Primary prostate cancer samples.

lung squamous cell carcinoma study 1 / normal lung tissue

Relative Expression (log2-ratio):-3.6290617
Number of Samples:31 / 44
Experimental lung squamous cell carcinoma study 1
Primary lung squamous cell carcinoma samples of a patient with non-small cell lung cancer.
Control normal lung tissue
Histologically normal lung tissue.

non-small cell lung cancer study 8 (squamous cell carcinoma) / adjacent lung tissue

Relative Expression (log2-ratio):-3.2270412
Number of Samples:27 / 65
Experimental non-small cell lung cancer study 8 (squamous cell carcinoma)
Primary tumor tissue sample obtained from the lung of patients squamous cell carcinoma.
Control adjacent lung tissue
Histological normal lung tissue samples from patients with lung cancer.

colorectal cancer study 43 (metastase; lung) / colorectal cancer study 43 (metastase; liver)

Relative Expression (log2-ratio):3.0981007
Number of Samples:5 / 25
Experimental colorectal cancer study 43 (metastase; lung)
Metastatic tumor tissue obtained from the lung of patients with primary colon adenocarcinoma.
Control colorectal cancer study 43 (metastase; liver)
Metastatic tumor tissue obtained from the liver of patients with primary colon adenocarcinoma.

R547 study 1 (24h) / vehicle (DMSO) treated DU145 cell sample

Relative Expression (log2-ratio):-3.0536737
Number of Samples:2 / 4
Experimental R547 study 1 (24h)
Human prostate carcinoma metastatic cell line DU145 treated with the CDK inhibitor R547 [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino) pyrimidin-5-yl]-(2, 3-difluoro-6-methoxyphenyl)methanone (Hoffmann-La Roche compound) for 24 hours at a 3xIC90 concentration of 5.1 ╬╝mol/L. ATC code:---
Control vehicle (DMSO) treated DU145 cell sample
Human prostate carcinoma metastatic cell line DU145 treated with vehicle (DMSO) for 24 hours.