TOP TEN perturbations for 1334_s_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1334_s_at
Selected probe(set): 207442_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1334_s_at (207442_at) across 6622 perturbations tested by GENEVESTIGATOR:

F. tularensis study 1 (novicida) / uninfected peripheral blood monocyte sample

Relative Expression (log2-ratio):6.5858536
Number of Samples:4 / 6
Experimental F. tularensis study 1 (novicida)
Peripheral blood monocytes infected with the Francisella tularensis subspecies novicida isolate U112 (100 MOI) for 24 hours.
Control uninfected peripheral blood monocyte sample
Peripheral blood monocytes uninfected.

E. coli study 2 / unstimulated, normal monocyte-derived macrophage sample

Relative Expression (log2-ratio):5.9879074
Number of Samples:5 / 7
Experimental E. coli study 2
Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours with 2.5 × 105 heat-killed E. coli.
Control unstimulated, normal monocyte-derived macrophage sample
Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours unstimulated.

E. coli study 1 / unstimulated, normal monocyte-derived macrophage sample

Relative Expression (log2-ratio):5.0311813
Number of Samples:12 / 16
Experimental E. coli study 1
Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours with 2.5 × 105 heat-killed E. coli.
Control unstimulated, normal monocyte-derived macrophage sample
Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours unstimulated.

PMA study 6 (500ng/ml) / vehicle (DME) treated bronchial epithelial cell sample

Relative Expression (log2-ratio):4.803605
Number of Samples:3 / 17
Experimental PMA study 6 (500ng/ml)
Bronchial epithelial cells (NHBE) treated with tetradecanoylphorbol acetate (500ng/ml; vendor: Sigma / catalog number: P1585 / catalog name: Phorbol 12-myristate 13-acetate [16561-29-8]) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). ATC code:---
Control vehicle (DME) treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) treated with vehicle (DME) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial).

prostate cancer study 8 (p. canc) / prostate cancer study 8 (ptasc)

Relative Expression (log2-ratio):-4.1832123
Number of Samples:3 / 2
Experimental prostate cancer study 8 (p. canc)
CD26+ FACS sorted prostate neoplasm cell (p. canc) samples from patients with primary prostate cancer collected after radical prostatectomy.
Control prostate cancer study 8 (ptasc)
CD90+ FACS sorted prostate tumor-associated stromal cell (ptasc) samples from patients with primary prostate cancer collected after radical prostatectomy.

respiratory syncytial virus study 1 / mock infected mixed dendritic cell sample

Relative Expression (log2-ratio):4.150077
Number of Samples:2 / 3
Experimental respiratory syncytial virus study 1
Respiratory syncytial virus (RSV) infected mixed cultures of primary plasmacytoid and conventional dendritic cells from healthy adult donors. Cells were infected at a MOI of 3.0 with RSV wild-type strain A2 grown in HEp-2 cells and extracted 24 hours post-infection.
Control mock infected mixed dendritic cell sample
Mock infected mixed cultures of primary plasmacytoid and conventional dendritic cells from healthy adult donors. Cells were mock infected with a supernatant from a parallel uninfected HEp-2 cell-culture monolayer and extracted 24 hours post-infection.

lung transplantation study 1 (post-transplant) / lung transplantation study 1 (pre-transplant)

Relative Expression (log2-ratio):4.1308193
Number of Samples:5 / 6
Experimental lung transplantation study 1 (post-transplant)
Lung tissue samples from donors after cardiac death (DCD) two hours after reperfusion.
Control lung transplantation study 1 (pre-transplant)
Lung tissue samples from donors after cardiac death (DCD) just after preservation.

VTX-2337 study 1 / 3M-055 study 1

Relative Expression (log2-ratio):4.08881
Number of Samples:3 / 3
Experimental VTX-2337 study 1
Peripheral blood monocytes isolated from healthy donors. Cells were treated overnight with 1uM VTX-2337 drug, which represents a TLR8 (Toll-like receptor 8) agonist with potential immunostimulating and antineoplastic activities.
Control 3M-055 study 1
Peripheral blood monocytes isolated from healthy donors. Cells were treated overnight with 1uM 3M-055 drug, which represents a TLR7 (Toll-like receptor 7) agonist.

VTX-2337 study 1 / untreated monocyte sample

Relative Expression (log2-ratio):4.03841
Number of Samples:3 / 3
Experimental VTX-2337 study 1
Peripheral blood monocytes isolated from healthy donors. Cells were treated overnight with 1uM VTX-2337 drug, which represents a TLR8 (Toll-like receptor 8) agonist with potential immunostimulating and antineoplastic activities.
Control untreated monocyte sample
Peripheral blood monocytes isolated from healthy donors.

trophoblast conditioned media study 1 (late) / progesterone decidualized endometrial stromal cell sample

Relative Expression (log2-ratio):3.7247877
Number of Samples:2 / 3
Experimental trophoblast conditioned media study 1 (late)
Human endometrial stromal cells were decidualized with progesterone and were further treated with conditioned media from human trophoblasts (TCM) for 12h.
Control progesterone decidualized endometrial stromal cell sample
Human endometrial stromal cells were decidualized with progesterone and were further treated with conditioned media from non-decidualized stromal cells for 12h.