TOP TEN perturbations for 1350_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1350_at
Selected probe(set): 210452_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1350_at (210452_x_at) across 6673 perturbations tested by GENEVESTIGATOR:

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-6.700673
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

methyl methanesulfonate study 6 (320µM) / untreated TK6 cell sample

Relative Expression (log2-ratio):5.0491943
Number of Samples:3 / 15
Experimental methyl methanesulfonate study 6 (320µM)
TK6 cells treated with 320µM methyl methanesulfonate for 24h. ATC code:---
Control untreated TK6 cell sample
Untreated TK6 cell line. Cells where left untreated for 24h before harvesting.

Hep-G2 / HepaRG

Relative Expression (log2-ratio):-4.276929
Number of Samples:9 / 12
Experimental Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

clear cell renal cell carcinoma study 4 (stage 1) / normal kidney tissue

Relative Expression (log2-ratio):-4.0603676
Number of Samples:23 / 69
Experimental clear cell renal cell carcinoma study 4 (stage 1)
Primary tumor tissue from patients with stage 1 clear cell renal cell carcinoma (ccRCC).
Control normal kidney tissue
Normal kidney tissue samples obtained from healthy individuals.

decitabine; TSA study 5 / mock treated small airway epithelial cell sample

Relative Expression (log2-ratio):4.0358915
Number of Samples:3 / 3
Experimental decitabine; TSA study 5
Small airway epithelial cells treated with 5uM 5-aza-2'-deoxycitidine (INN: decitabine) for 72 hours and trichostatin A (TSA) for 24 hours (stock solutions of 5-aza-2'-deoxycitidine and TSA were dissolved in 100% ethanol). ATC code:
Control mock treated small airway epithelial cell sample
Small airway epithelial cells mock treated.

hepatoblastoma study 1 (NOS) / normal liver tissue

Relative Expression (log2-ratio):-3.9858713
Number of Samples:5 / 5
Experimental hepatoblastoma study 1 (NOS)
Liver tumor tissue samples from children with hepatoblastoma (NOS). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.

clear cell renal cell carcinoma study 4 (stage 3) / normal kidney tissue

Relative Expression (log2-ratio):-3.9287052
Number of Samples:14 / 69
Experimental clear cell renal cell carcinoma study 4 (stage 3)
Primary tumor tissue from patients with stage 3 clear cell renal cell carcinoma (ccRCC).
Control normal kidney tissue
Normal kidney tissue samples obtained from healthy individuals.

hepatoblastoma study 1 (mixed epithelial and mesenchymal) / normal liver tissue

Relative Expression (log2-ratio):-3.896903
Number of Samples:4 / 5
Experimental hepatoblastoma study 1 (mixed epithelial and mesenchymal)
Liver tumor tissue samples from children with hepatoblastoma (mesenchymal type (MEM-HB); mixed epithelial and mesenchymal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.

clear cell renal cell carcinoma study 4 (stage 2) / normal kidney tissue

Relative Expression (log2-ratio):-3.8881035
Number of Samples:19 / 69
Experimental clear cell renal cell carcinoma study 4 (stage 2)
Primary tumor tissue from patients with stage 2 clear cell renal cell carcinoma (ccRCC).
Control normal kidney tissue
Normal kidney tissue samples obtained from healthy individuals.

hepatoblastoma study 1 (embryonal) / normal liver tissue

Relative Expression (log2-ratio):-3.8596554
Number of Samples:7 / 5
Experimental hepatoblastoma study 1 (embryonal)
Liver tumor tissue samples from children with hepatoblastoma (epithelial type (E-HB); embryonal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.