TOP TEN perturbations for 1464_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1464_at
Selected probe(set): 210881_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1464_at (210881_s_at) across 6622 perturbations tested by GENEVESTIGATOR:

expO stomach cancer study 1 (gastrointestinal stromal tumor; primary) / expO stomach cancer study 1 (Signet ring cell carcinoma; primary)

Relative Expression (log2-ratio):6.989748
Number of Samples:2 / 2
Experimental expO stomach cancer study 1 (gastrointestinal stromal tumor; primary)
Primary tumor tissue samples obtained from the stomach of patients with gastrointestinal stromal tumor.
Control expO stomach cancer study 1 (Signet ring cell carcinoma; primary)
Primary tumor tissue samples obtained from the stomach of patients with Signet ring cell carcinoma.

expO stomach cancer study 1 (gastrointestinal stromal tumor; primary) / expO stomach cancer study 1 (adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):6.6592865
Number of Samples:2 / 3
Experimental expO stomach cancer study 1 (gastrointestinal stromal tumor; primary)
Primary tumor tissue samples obtained from the stomach of patients with gastrointestinal stromal tumor.
Control expO stomach cancer study 1 (adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the stomach of patients with adenocarcinoma (NOS).

hepatocyte-like cell differentiation study 1 (20d; HNF4 depl) / hepatocyte-like cell differentiation study 1 (5d)

Relative Expression (log2-ratio):6.586712
Number of Samples:3 / 3
Experimental hepatocyte-like cell differentiation study 1 (20d; HNF4 depl)
Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09) and transfected with shRNA targeting HNF4A. ES cells were grown in human ES cell media DMEM/F12 and differentiated to mature hepatocytes for 20 days. Moreover hESc was stable transfected with lentivirus expressing an shRNA that efficiently depletes HNF4A.
Control hepatocyte-like cell differentiation study 1 (5d)
Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to definitive endoderm for 5 days.

hepatocyte-like cell differentiation study 1 (20d; HNF4 depl) / hepatocyte-like cell differentiation study 1 (10d)

Relative Expression (log2-ratio):4.7730618
Number of Samples:3 / 3
Experimental hepatocyte-like cell differentiation study 1 (20d; HNF4 depl)
Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09) and transfected with shRNA targeting HNF4A. ES cells were grown in human ES cell media DMEM/F12 and differentiated to mature hepatocytes for 20 days. Moreover hESc was stable transfected with lentivirus expressing an shRNA that efficiently depletes HNF4A.
Control hepatocyte-like cell differentiation study 1 (10d)
Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to hepatic specification stage for 10 days.

adrenal gland cancer study 2 / adrenal gland cancer study 1

Relative Expression (log2-ratio):4.5901995
Number of Samples:31 / 22
Experimental adrenal gland cancer study 2
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma.
Control adrenal gland cancer study 1
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical adenoma.

nephroblastoma study 2 / normal kidney tissue

Relative Expression (log2-ratio):4.581809
Number of Samples:4 / 3
Experimental nephroblastoma study 2
Tumor tissue samples from the kidney of patients with Wilms’ tumor.
Control normal kidney tissue
Normal adult kidney tissue samples.

adrenal gland cancer study 4 / normal adrenal cortex tissue

Relative Expression (log2-ratio):4.5129433
Number of Samples:43 / 4
Experimental adrenal gland cancer study 4
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma (ACC).
Control normal adrenal cortex tissue
Histological normal adrenal gland cortical tissue samples derived after autopsy.

brain tumor study 1 (ependymoma) / normal brain tissue

Relative Expression (log2-ratio):4.330168
Number of Samples:46 / 12
Experimental brain tumor study 1 (ependymoma)
Primary tumor tissue sample from the brain of patients with ependymoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

adrenal gland cancer study 2 / normal adrenal cortex tissue

Relative Expression (log2-ratio):4.293619
Number of Samples:31 / 10
Experimental adrenal gland cancer study 2
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma.
Control normal adrenal cortex tissue
Unaffected adrenal cortex tissue from control objects.

bone cancer study 1 (PDX; chondroblastic osteosarcoma; primary) / bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)

Relative Expression (log2-ratio):-4.1356297
Number of Samples:2 / 2
Experimental bone cancer study 1 (PDX; chondroblastic osteosarcoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary chondroblastic osteosarcoma of the bone (subcutaneously implanted).
Control bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary myxoid chondrosarcoma of the bone (subcutaneously implanted).