TOP TEN perturbations for 1487_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1487_at
Selected probe(set): 1487_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1487_at (1487_at) across 6537 perturbations tested by GENEVESTIGATOR:
renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue
Relative Expression (log2-ratio):2.3515415Number of Samples:4 / 2
Experimental | renal cell carcinoma study 6 (chromophobe type) |
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC). | |
Control | normal kidney tissue |
Normal fetal kidney tissue samples. |
dysferlinopathy study 2 (LGMD2B; severe) / normal vastus lateralis tissue
Relative Expression (log2-ratio):-1.9726858Number of Samples:2 / 6
Experimental | dysferlinopathy study 2 (LGMD2B; severe) |
Biopsies of vastus lateralis muscle from male patients with limb-girdle muscular dystrophy 2B (LGMD2B) and severe fibrotic replacement. All subjects showed evidence of a dystrophic process (degeneration/regeneration of muscle fibers) and dysferlin mutation. | |
Control | normal vastus lateralis tissue |
Biopsies of vastus lateralis muscle from young adult volunteers. Samples were taken as normal controls from baseline samples of exercise experiments. |
PGC-1 overexpr. study 1 (2x9) / control transfected HEPG2 sample
Relative Expression (log2-ratio):1.706912Number of Samples:3 / 3
Experimental | PGC-1 overexpr. study 1 (2x9) |
HEP-G2 cells infected with adenoviruses carrying a mutant form of PPARG Coactivator 1 Alpha (PGC-1) where L2 and L3 motifs of PGC-1 were replaced with sequences corresponding to the L3-09 peptide (2x9). Cells were analyzed 24 hours after infection. | |
Control | control transfected HEPG2 sample |
HEp-G2 cells infected with adenoviruses carrying B-galactosidase as a control. Cells were analyzed 24 hours after infection. |
oxyphilic adenoma study 1 / normal kidney tissue
Relative Expression (log2-ratio):1.702281Number of Samples:4 / 2
Experimental | oxyphilic adenoma study 1 |
Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma). | |
Control | normal kidney tissue |
Normal fetal kidney tissue samples. |
Becker muscular dystrophy study 2 (moderate) / normal vastus lateralis tissue
Relative Expression (log2-ratio):-1.6392584Number of Samples:3 / 6
Experimental | Becker muscular dystrophy study 2 (moderate) |
Biopsies of vastus lateralis muscle from male patients with Becker muscular dystrophy and moderate fibrotic replacement. All subjects showed evidence of a dystrophic process (degeneration/regeneration of muscle fibers) and abnormal dystrophin. | |
Control | normal vastus lateralis tissue |
Biopsies of vastus lateralis muscle from young adult volunteers. Samples were taken as normal controls from baseline samples of exercise experiments. |
PGC-1 overexpr. study 1 (WT) / control transfected HEPG2 sample
Relative Expression (log2-ratio):1.6225538Number of Samples:3 / 3
Experimental | PGC-1 overexpr. study 1 (WT) |
HEP-G2 cells infected with adenoviruses carrying a wild-type form of PPARG Coactivator 1 Alpha (PGC-1). Cells were analyzed 24 hours after infection. | |
Control | control transfected HEPG2 sample |
HEp-G2 cells infected with adenoviruses carrying B-galactosidase as a control. Cells were analyzed 24 hours after infection. |
myotonic dystrophy study 4 (deltoid muscle; DM-like) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):1.6133804Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (deltoid muscle; DM-like) |
Deltoid muscle biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
Sjogren's syndrome study 1 (advanced) / normal minor salivary gland tissue
Relative Expression (log2-ratio):-1.6007729Number of Samples:2 / 4
Experimental | Sjogren's syndrome study 1 (advanced) |
Whole minor salivary gland samples of patients with advanced Sjogren's syndrome. | |
Control | normal minor salivary gland tissue |
Whole minor salivary gland samples from non-Sjogren's syndrome control subjects. |
lung cancer study 1 (PDX; large cell carcinoma, NOS; primary) / lung cancer study 1 (PDX; adenosquamous carcinoma; primary)
Relative Expression (log2-ratio):-1.5600986Number of Samples:4 / 4
Experimental | lung cancer study 1 (PDX; large cell carcinoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary large cell carcinoma, NOS of the lung (subcutaneously implanted). | |
Control | lung cancer study 1 (PDX; adenosquamous carcinoma; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary adenosquamous carcinoma of the lung (subcutaneously implanted). |
colorectal adenoma study 2 / normal colon tissue
Relative Expression (log2-ratio):-1.5488195Number of Samples:5 / 6
Experimental | colorectal adenoma study 2 |
Laser microdissected human adenoma sample. | |
Control | normal colon tissue |
Laser microdissected human colonic epithelial cells sample. |
Organism: Homo sapiens
Gene: 1487_at
Selected probe(set): 203193_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1487_at (203193_at) across 6537 perturbations tested by GENEVESTIGATOR:
renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue
Relative Expression (log2-ratio):1.510088Number of Samples:4 / 2
Experimental | renal cell carcinoma study 6 (chromophobe type) |
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC). | |
Control | normal kidney tissue |
Normal fetal kidney tissue samples. |
oxyphilic adenoma study 1 / normal kidney tissue
Relative Expression (log2-ratio):1.3307981Number of Samples:4 / 2
Experimental | oxyphilic adenoma study 1 |
Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma). | |
Control | normal kidney tissue |
Normal fetal kidney tissue samples. |
influenza virus study 11 (A/H5N3) / influenza virus study 4 (A/H1N1)
Relative Expression (log2-ratio):-1.3142242Number of Samples:3 / 3
Experimental | influenza virus study 11 (A/H5N3) |
Human carcinoma cell line A549 infected with influenza A virus subtype influenza virus A/duck/Malaysia/F119/3/1997(H5N3). Samples were taken 10 hours post-infection. | |
Control | influenza virus study 4 (A/H1N1) |
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection. |
influenza virus study 9 (A/pH1N1) / influenza virus study 4 (A/H1N1)
Relative Expression (log2-ratio):-1.2662811Number of Samples:3 / 3
Experimental | influenza virus study 9 (A/pH1N1) |
Human carcinoma cell line A549 infected with influenza A virus subtype [A/Singapore/478/2009 (pH1N1)]. Samples were taken 10 hours post-infection. | |
Control | influenza virus study 4 (A/H1N1) |
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection. |
influenza virus study 10 (A/H5N2) / influenza virus study 4 (A/H1N1)
Relative Expression (log2-ratio):-1.2393436Number of Samples:3 / 3
Experimental | influenza virus study 10 (A/H5N2) |
Human carcinoma cell line A549 infected with influenza A virus subtype influenza virus A/duck/Malaysia/F189/07/2004(H5N2). Samples were taken 10 hours post-infection. | |
Control | influenza virus study 4 (A/H1N1) |
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection. |
dysferlinopathy study 2 (LGMD2B; severe) / normal vastus lateralis tissue
Relative Expression (log2-ratio):-1.1764679Number of Samples:2 / 6
Experimental | dysferlinopathy study 2 (LGMD2B; severe) |
Biopsies of vastus lateralis muscle from male patients with limb-girdle muscular dystrophy 2B (LGMD2B) and severe fibrotic replacement. All subjects showed evidence of a dystrophic process (degeneration/regeneration of muscle fibers) and dysferlin mutation. | |
Control | normal vastus lateralis tissue |
Biopsies of vastus lateralis muscle from young adult volunteers. Samples were taken as normal controls from baseline samples of exercise experiments. |
myotonic dystrophy study 4 (biceps brachii; DM-like) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):1.1732807Number of Samples:9 / 3
Experimental | myotonic dystrophy study 4 (biceps brachii; DM-like) |
Biceps brachii biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (skeletal muscle; DM2) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):1.1478834Number of Samples:8 / 3
Experimental | myotonic dystrophy study 4 (skeletal muscle; DM2) |
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (deltoid muscle; DM2) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):1.1414566Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (deltoid muscle; DM2) |
Deltoid muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
Duchenne muscular dystrophy study 4 / normal skeletal muscle tissue
Relative Expression (log2-ratio):-1.1313992Number of Samples:16 / 6
Experimental | Duchenne muscular dystrophy study 4 |
Skeletal muscle biopsies obtained from boys with Duchenne muscular dystrophy. | |
Control | normal skeletal muscle tissue |
Histologically normal skeletal muscle biopsies. |