TOP TEN perturbations for 1546_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1546_at
Selected probe(set): 210619_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1546_at (210619_s_at) across 6672 perturbations tested by GENEVESTIGATOR:

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-5.5449553
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

hepatocyte (ESC) / Hep-G2

Relative Expression (log2-ratio):-4.9534874
Number of Samples:8 / 9
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:

nephroblastoma study 2 / normal kidney tissue

Relative Expression (log2-ratio):-4.081128
Number of Samples:4 / 3
Experimental nephroblastoma study 2
Tumor tissue samples from the kidney of patients with Wilms’ tumor.
Control normal kidney tissue
Normal adult kidney tissue samples.

collecting duct carcinoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):-3.9249144
Number of Samples:2 / 3
Experimental collecting duct carcinoma study 1
Tumor tissue samples from the kidney of patients with collecting duct carcinoma (CDC).
Control normal kidney tissue
Normal adult kidney tissue samples.

renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue

Relative Expression (log2-ratio):3.9130325
Number of Samples:4 / 2
Experimental renal cell carcinoma study 6 (chromophobe type)
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC).
Control normal kidney tissue
Normal fetal kidney tissue samples.

MALT lymphoma study 2 / normal spleen tissue

Relative Expression (log2-ratio):-3.6646385
Number of Samples:6 / 6
Experimental MALT lymphoma study 2
Human t(11;18)-positive mucosa-associated lymphoid tissue (MALT) lymphoma cells.
Control normal spleen tissue
Normal human spleen tissue sample.

oxyphilic adenoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):3.5785093
Number of Samples:4 / 2
Experimental oxyphilic adenoma study 1
Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma).
Control normal kidney tissue
Normal fetal kidney tissue samples.

Barrett's esophagus study 3 / normal esophageal epithelium sample

Relative Expression (log2-ratio):3.5292234
Number of Samples:17 / 18
Experimental Barrett's esophagus study 3
Esophageal epithelium samples from areas with Barrett's esophagus metaplasia which were recovered by laser capture microdissection.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

lung adenocarcinoma study 6 (K-RAS mut) / adjacent lung tissue

Relative Expression (log2-ratio):-3.38725
Number of Samples:6 / 20
Experimental lung adenocarcinoma study 6 (K-RAS mut)
Primary tumor sample from patients with stage II adenocarcinoma carrying a K-RAS mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

ALDH1A1/ALDH3A1 depletion study 1 (siRNA) / control transfected A-549 cell sample

Relative Expression (log2-ratio):3.2656775
Number of Samples:4 / 4
Experimental ALDH1A1/ALDH3A1 depletion study 1 (siRNA)
Human primary cancer cell line A-549 stably transduced with lentiviral vectors containing specific siRNA sequences against ALDH1A1 (Aldehyde dehydrogenase 1 family, member A1) and ALDH3A1 (Aldehyde dehydrogenase 3 family, member A1) (Lenti 1+3 cells).
Control control transfected A-549 cell sample
Human primary cancer cell line A-549 stably transduced with lentiviral vector containing siRNA against GFP. 4 clones of control cell line were prepared (clone GFP1-4).