TOP TEN perturbations for 1552263_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552263_at
Selected probe(set): 224621_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552263_at (224621_at) across 6673 perturbations tested by GENEVESTIGATOR:

MAPK1 depletion study 1 / control vector transfected SW-480 cell sample

Relative Expression (log2-ratio):-2.5473337
Number of Samples:6 / 6
Experimental MAPK1 depletion study 1
RNAi-mediated gene knockdown of MAPK1 in colorectal cancer cell line SW-480.
Control control vector transfected SW-480 cell sample
SW-480 colorectal cell line sample transduced with empty vector pLKO.

MAPK1 depletion study 1 / normal SW-480 cell sample

Relative Expression (log2-ratio):-2.378952
Number of Samples:6 / 3
Experimental MAPK1 depletion study 1
RNAi-mediated gene knockdown of MAPK1 in colorectal cancer cell line SW-480.
Control normal SW-480 cell sample
Non-transduced SW-480 colorectal cell line sample.

MAPK1 depletion study 1 / mock transfected SW-480 cell sample

Relative Expression (log2-ratio):-2.3222494
Number of Samples:6 / 6
Experimental MAPK1 depletion study 1
RNAi-mediated gene knockdown of MAPK1 in colorectal cancer cell line SW-480.
Control mock transfected SW-480 cell sample
SW-480 colorectal cell line sample transduced with non-targeting pLKO_NonTarget vector.

zalypsis study 2 / untreated OPM1 cell sample

Relative Expression (log2-ratio):-2.3220978
Number of Samples:2 / 2
Experimental zalypsis study 2
OPM1 multiple myeloma cells treated in vitro with zalypsis (5 nM), a novel marine-derived compound with potent antimyeloma activity. Cells were harvested at the beginning of induction of cell death (15-20% cell death as assessed by Annexin V-FITC staining). ATC code:---
Control untreated OPM1 cell sample
OPM1 multiple myeloma cells untreated.

medulloblastoma study 2 / non-tumor brain tissue

Relative Expression (log2-ratio):-2.029335
Number of Samples:4 / 9
Experimental medulloblastoma study 2
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

peptidoglycan study 1 / mock treated neonatal neutrophils

Relative Expression (log2-ratio):-1.8945093
Number of Samples:3 / 3
Experimental peptidoglycan study 1
Healthy neonatal neutrophils with ≥ 99% purity isolated from cord blood samples collected after normal, full-term, vaginal delivery treated with peptidoglycan isolated from S. aureus (10 ug/ml) for 4 hours.
Control mock treated neonatal neutrophils
Healthy neonatal neutrophils with ≥ 99% purity isolated from cord blood samples collected after normal, full-term, vaginal delivery mock treated for 4 hours.

kidney transplantation study 16 (2 week) / normal natural killer cell (CD56+) sample

Relative Expression (log2-ratio):-1.8912344
Number of Samples:3 / 3
Experimental kidney transplantation study 16 (2 week)
CD56+ natural killer cell samples derived from kidney transplant patients 2 weeks post-transplantation. Samples were collected 2 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH).
Control normal natural killer cell (CD56+) sample
CD56+ natural killer cell samples derived from healthy control subjects.

T-cell isolation study 11 / T-cell isolation study 6

Relative Expression (log2-ratio):-1.8887949
Number of Samples:2 / 2
Experimental T-cell isolation study 11
CD4+ resting memory T-cell were isolated from peripheral blood buffy coat of healthy donors after storage for 24 hours at 20°C. The cell fraction was first enriched via density gradient centrifugation with LSM 1077 Ficoll and than FACS sorted as CD3+/CD4+/CD45RO+/CD45RA- population.
Control T-cell isolation study 6
CD4+ resting memory T-cell were isolated from whole peripheral blood of healthy donors with no delay. The cell fraction was first enriched via density gradient centrifugation with LSM 1077 Ficoll and than FACS sorted as CD3+/CD4+/CD45RO+/CD45RA- population.

ovarian tumor study 13 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):-1.8596115
Number of Samples:18 / 12
Experimental ovarian tumor study 13
Human epithelial tumor cell samples from the ovary of patients with serous adenocarcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue from healthy donors. Samples were derived by cell surface brushing.

glioma study 16 (LN-215) / normal astrocyte sample

Relative Expression (log2-ratio):-1.8145704
Number of Samples:2 / 3
Experimental glioma study 16 (LN-215)
Human glioma cell line LN215 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.