TOP TEN perturbations for 1552293_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552293_at
Selected probe(set): 236705_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552293_at (236705_at) across 6673 perturbations tested by GENEVESTIGATOR:

glioma study 17 (anaplastic astrocytoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):-4.592886
Number of Samples:2 / 3
Experimental glioma study 17 (anaplastic astrocytoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from high grade anaplastic astrocytoma (grade III). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 45 ± 18 years old.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

glioma study 17 (glioblastoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):-3.9317904
Number of Samples:3 / 3
Experimental glioma study 17 (glioblastoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from high grade glioblastoma (grade IV). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 66 ± 5 years old males.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

autosomal dominant polycystic kidney disease study 1 (large cyst) / autosomal dominant polycystic kidney disease study 1 (small cyst)

Relative Expression (log2-ratio):3.3662863
Number of Samples:3 / 5
Experimental autosomal dominant polycystic kidney disease study 1 (large cyst)
Large cyst samples (with more than 50 ml volume) from patients with autosomal dominant polycystic kidney disease (ADPKD). Cysts were sampled after nephrectomy.
Control autosomal dominant polycystic kidney disease study 1 (small cyst)
Small cyst samples (with less than 1ml volume) from patients with autosomal dominant polycystic kidney disease (ADPKD). Cysts were sampled after nephrectomy.

ovulation study 1 / proliferative phase endometrium tissue

Relative Expression (log2-ratio):3.3196354
Number of Samples:3 / 4
Experimental ovulation study 1
Early secretory phase (ESE) endometrium tissue.
Control proliferative phase endometrium tissue
Proliferative phase (PE) endometrium tissue.

atypical teratoid/rhabdoid tumor study 1 / non-tumor brain tissue

Relative Expression (log2-ratio):-3.2551079
Number of Samples:20 / 9
Experimental atypical teratoid/rhabdoid tumor study 1
Primary tumor tissue sample from the brain of pediatric patients with atypical teratoid/rhabdoid tumor (AT/RT).
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

ovulation study 2 / proliferative phase endometrium tissue

Relative Expression (log2-ratio):3.0535479
Number of Samples:8 / 4
Experimental ovulation study 2
Mid secretory phase (MSE) endometrium tissue.
Control proliferative phase endometrium tissue
Proliferative phase (PE) endometrium tissue.

rheumatoid arthritis study 64 (RTX; mPRED; 12wk; poor resp.) / rheumatoid arthritis study 64 (RTX; mPRED; 12wk; good resp.)

Relative Expression (log2-ratio):-2.932539
Number of Samples:3 / 3
Experimental rheumatoid arthritis study 64 (RTX; mPRED; 12wk; poor resp.)
Synovium tissue samples from patients with active rheumatoid arthritis (RA) collected 12 weeks after treatment with rituximab (RTX) and methylprednisolone (mPRED). These patients were evaluated as poor responders (non-responders) to the treatment according to the European League Against Rheumatism (EULAR) response criteria. RTX was administered intravenously at a dose of 1,000 mg at baseline and at week 2, together with 125 mg intravenously mPRED. The patients fulfilled the American College of Rheumatology 1987 revised classification criteria for RA. All had erosive changes imaged on conventional radiographs of the hands and/or feet. Each of them had a swollen knee at inclusion. Synovial biopsies were obtained by needle arthroscopy of an affected knee. For RNA isolation 4 – 8 synovial biopsy samples were used. rituximab ATC code: methylprednisolone ATC code:, ,
Control rheumatoid arthritis study 64 (RTX; mPRED; 12wk; good resp.)
Synovium tissue samples from patients with active rheumatoid arthritis (RA) collected 12 weeks after treatment with rituximab (RTX) and methylprednisolone (mPRED). These patients were evaluated as good responders to the treatment according to the European League Against Rheumatism (EULAR) response criteria. RTX was administered intravenously at a dose of 1,000 mg at baseline and at week 2, together with 125 mg intravenously mPRED. The patients fulfilled the American College of Rheumatology 1987 revised classification criteria for RA. All had erosive changes imaged on conventional radiographs of the hands and/or feet. Each of them had a swollen knee at inclusion. Synovial biopsies were obtained by needle arthroscopy of an affected knee. For RNA isolation 4 – 8 synovial biopsy samples were used. rituximab ATC code: methylprednisolone ATC code:, ,

HIV-associated neurocognitive disorder study 7 (normal) / HIV-associated neurocognitive disorder study 6 (normal)

Relative Expression (log2-ratio):2.9315596
Number of Samples:2 / 2
Experimental HIV-associated neurocognitive disorder study 7 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients received antiretroviral therapy (ART).
Control HIV-associated neurocognitive disorder study 6 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients did not receive any antiretroviral therapy (ART).

glioma study 5 / non-tumor brain tissue

Relative Expression (log2-ratio):-2.858646
Number of Samples:12 / 9
Experimental glioma study 5
Primary tumor tissue sample from the supratentorial brain of pediatric patients with glioblastoma multiformae.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

brain tumor study 1 (ependymoma) / normal brain tissue

Relative Expression (log2-ratio):-2.8149724
Number of Samples:46 / 12
Experimental brain tumor study 1 (ependymoma)
Primary tumor tissue sample from the brain of patients with ependymoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.