TOP TEN perturbations for 1552398_a_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1552398_a_at
Selected probe(set): 1552398_a_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1552398_a_at (1552398_a_at) across 6540 perturbations tested by GENEVESTIGATOR:
CML study 1 / B-CLL study 5
Relative Expression (log2-ratio):4.8143454Number of Samples:75 / 441
Experimental | CML study 1 |
Bone marrow samples of patients with chronic myeloid leukemia (CML). | |
Control | B-CLL study 5 |
Bone marrow samples of patients with B-cell chronic lymphocytic leukemia (B-CLL). |
B-ALL study 1 (hyperdiploid) / normal bone marrow sample
Relative Expression (log2-ratio):-4.6178093Number of Samples:40 / 74
Experimental | B-ALL study 1 (hyperdiploid) |
Bone marrow samples of patients with hyperdiploid B-ALL (hyperdiploid karyotype). | |
Control | normal bone marrow sample |
Non-leukemic and healthy bone marrow sample. |
precursor-B-ALL study 1 (t(12;21)(p12,q22)) / normal bone marrow sample
Relative Expression (log2-ratio):-4.4812717Number of Samples:58 / 74
Experimental | precursor-B-ALL study 1 (t(12;21)(p12,q22)) |
Bone marrow samples of patients with precursor B-ALL (t(12;21)(p12,q22)/TEL-AML1). | |
Control | normal bone marrow sample |
Non-leukemic and healthy bone marrow sample. |
precursor-B-ALL study 1 (t(1;19)(q23,q13)) / normal bone marrow sample
Relative Expression (log2-ratio):-4.352275Number of Samples:36 / 74
Experimental | precursor-B-ALL study 1 (t(1;19)(q23,q13)) |
Bone marrow samples of patients with precursor B-ALL (t(1;19)(q23,q13)/E2A-PBX1). | |
Control | normal bone marrow sample |
Non-leukemic and healthy bone marrow sample. |
precursor-B-ALL study 1 (t(11q23)) / normal bone marrow sample
Relative Expression (log2-ratio):-4.3069525Number of Samples:70 / 74
Experimental | precursor-B-ALL study 1 (t(11q23)) |
Bone marrow samples of patients with precursor B-ALL (t(11q23)/MLL). | |
Control | normal bone marrow sample |
Non-leukemic and healthy bone marrow sample. |
B-CLL study 5 / normal bone marrow sample
Relative Expression (log2-ratio):-4.074356Number of Samples:441 / 74
Experimental | B-CLL study 5 |
Bone marrow samples of patients with B-cell chronic lymphocytic leukemia (B-CLL). | |
Control | normal bone marrow sample |
Non-leukemic and healthy bone marrow sample. |
Langerhans cell histiocytosis study 1 / normal myeloid dendritic cell sample
Relative Expression (log2-ratio):-3.9970865Number of Samples:7 / 3
Experimental | Langerhans cell histiocytosis study 1 |
Langerhans cell histiocytes (LCH) were isolated from LCH lesions of patients undergoing surgery. All patients had single system disease, five patients had bone lesion, one had skin lesion and one had mucosal manifestation. Langerhans cells histiocytes were purified by FACS as CD1a+ / CD270 + population with > 95% purity. | |
Control | normal myeloid dendritic cell sample |
Normal myeloid dendritic cells were isolated from peripheral blood of healthy adult donors. Myeloid dendritic cells were defined as HLA-DR+ / CD11c + / BDCA1+ / BDCA3- population. |
DLBCL study 7 (GCB; plasmablast-like) / DLBCL study 7 (GCB; naive-like)
Relative Expression (log2-ratio):3.985446Number of Samples:3 / 2
Experimental | DLBCL study 7 (GCB; plasmablast-like) |
Primary tumor samples from patients with diffuse large B-cell lymphoma (germinal center B-cell like type). Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS) and assigned to plasmablast-like group. Patients were treated according to standard protocols, and comparable doses of RCHOP- like regimens were used. No patient was treated with stem cell transplantation. | |
Control | DLBCL study 7 (GCB; naive-like) |
Primary tumor samples from patients with diffuse large B-cell lymphoma (germinal center B-cell like type). Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS) and assigned to naive-like group. Patients were treated according to standard protocols, and comparable doses of RCHOP- like regimens were used. No patient was treated with stem cell transplantation. |
cutaneous sarcoidosis study 1 (lesional) / normal skin tissue
Relative Expression (log2-ratio):3.8847342Number of Samples:13 / 5
Experimental | cutaneous sarcoidosis study 1 (lesional) |
Lesional skin biopsies from patients with acute cutaneous sarcoidosis. | |
Control | normal skin tissue |
Skin biopsy samples from healthy control subjects. |
c-ALL/pre-B-ALL study 1 (t(9;22)(q34,q11)) / normal bone marrow sample
Relative Expression (log2-ratio):-3.8592615Number of Samples:121 / 74
Experimental | c-ALL/pre-B-ALL study 1 (t(9;22)(q34,q11)) |
Bone marrow samples of patients with c-ALL/pre-B-ALL (t(9;22)(q34,q11)/BCR-ABL). | |
Control | normal bone marrow sample |
Non-leukemic and healthy bone marrow sample. |