TOP TEN perturbations for 1552402_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552402_at
Selected probe(set): 1552402_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552402_at (1552402_at) across 6672 perturbations tested by GENEVESTIGATOR:

glycogen storage disease type II study 1 / normal biceps tissue

Relative Expression (log2-ratio):-3.8798666
Number of Samples:8 / 10
Experimental glycogen storage disease type II study 1
Biceps femoris muscle biopsy sample from patients with infantile onset Morbus Pompe (Pompe disease).
Control normal biceps tissue
Biceps femoris biopsy muscle samples from control subjects.

alglucosidase alfa study 1 (baseline) / normal quadriceps tissue

Relative Expression (log2-ratio):-3.78238
Number of Samples:11 / 7
Experimental alglucosidase alfa study 1 (baseline)
Quadriceps muscle biopsy sample from patients with glycogen storage disease type II (Morbus Pomps, Pompe disease). Sample was taken before starting a 52 weeks lasting therapy with recombinant human cid alpha-glucosidase (rhGAA; Myozyme). ATC code:
Control normal quadriceps tissue
Quadriceps biopsy muscle samples from control subjects.

inclusion body myositis study 1 / normal biceps tissue

Relative Expression (log2-ratio):-3.7420015
Number of Samples:5 / 3
Experimental inclusion body myositis study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).
Control normal biceps tissue
Biceps femoris biopsy muscle samples from control subjects.

dermatomyositis study 3 / normal biceps tissue

Relative Expression (log2-ratio):-3.0085564
Number of Samples:5 / 3
Experimental dermatomyositis study 3
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of dermatomyositis (DM).
Control normal biceps tissue
Biceps femoris biopsy muscle samples from control subjects.

polymyositis study 1 / normal biceps tissue

Relative Expression (log2-ratio):-2.943674
Number of Samples:5 / 3
Experimental polymyositis study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of polymyositis (PM).
Control normal biceps tissue
Biceps femoris biopsy muscle samples from control subjects.

Duchenne muscular dystrophy study 9 (biceps brachii) / normal skeletal muscle tisuue (fetal)

Relative Expression (log2-ratio):-2.7710943
Number of Samples:2 / 3
Experimental Duchenne muscular dystrophy study 9 (biceps brachii)
Biceps brachii biopsies obtained from patients with Duchenne muscular dystrophy DMD).
Control normal skeletal muscle tisuue (fetal)
Commercially purchased normal fetal skeletal muscle tissue samples.

alglucosidase alfa study 1 (week 12) / normal quadriceps tissue

Relative Expression (log2-ratio):-2.739421
Number of Samples:10 / 7
Experimental alglucosidase alfa study 1 (week 12)
Quadriceps muscle biopsy sample from patients with glycogen storage disease type II (Morbus Pomps, Pompe disease). Sample was taken 12 weeks after starting a 52 weeks lasting therapy with recombinant human cid alpha-glucosidase (rhGAA; Myozyme). ATC code:
Control normal quadriceps tissue
Quadriceps biopsy muscle samples from control subjects.

alglucosidase alfa study 1 (week 52) / normal quadriceps tissue

Relative Expression (log2-ratio):-2.6821938
Number of Samples:10 / 7
Experimental alglucosidase alfa study 1 (week 52)
Quadriceps muscle biopsy sample from patients with glycogen storage disease type II (Morbus Pomps, Pompe disease). Sample was taken 52 weeks after starting a 52 weeks lasting therapy with recombinant human cid alpha-glucosidase (rhGAA; Myozyme). ATC code:
Control normal quadriceps tissue
Quadriceps biopsy muscle samples from control subjects.

myotonic dystrophy study 4 (skeletal muscle; DM1) / normal skeletal muscle tisuue (fetal)

Relative Expression (log2-ratio):-2.4709463
Number of Samples:5 / 3
Experimental myotonic dystrophy study 4 (skeletal muscle; DM1)
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 1 (DM1).
Control normal skeletal muscle tisuue (fetal)
Commercially purchased normal fetal skeletal muscle tissue samples.

myotonic dystrophy study 4 (skeletal muscle; DM2) / myotonic dystrophy study 4 (skeletal muscle; DM1)

Relative Expression (log2-ratio):2.4512968
Number of Samples:8 / 5
Experimental myotonic dystrophy study 4 (skeletal muscle; DM2)
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2).
Control myotonic dystrophy study 4 (skeletal muscle; DM1)
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 1 (DM1).