TOP TEN perturbations for 1552449_a_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552449_a_at
Selected probe(set): 1552449_a_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552449_a_at (1552449_a_at) across 6673 perturbations tested by GENEVESTIGATOR:

expO peritoneal cancer study 1 (serous surface papillary carcinoma; metastatic) / expO peritoneal cancer study 1 (papillary serous cystadenocarcinoma; metastatic)

Relative Expression (log2-ratio):2.5489893
Number of Samples:2 / 12
Experimental expO peritoneal cancer study 1 (serous surface papillary carcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary serous surface papillary carcinoma of the peritoneum.
Control expO peritoneal cancer study 1 (papillary serous cystadenocarcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary papillary serous cystadenocarcinoma of the peritoneum.

ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary) / ovarian tumor study 30 (PDX; adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):1.9443817
Number of Samples:2 / 2
Experimental ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary adenocarcinoma, NOS of the ovary (subcutaneously implanted).

pancreatic cancer study 5 (PBMC) / normal PBMC sample

Relative Expression (log2-ratio):1.8783951
Number of Samples:3 / 10
Experimental pancreatic cancer study 5 (PBMC)
Peripheral blood mononuclear cell (PBMC) sample from pancreatic cancer patients.
Control normal PBMC sample
Peripheral blood mononuclear cell (PBMC) samples from healthy individuals.

ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary) / ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-1.816145
Number of Samples:2 / 2
Experimental ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary mixed tumor, malignant, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the ovary (subcutaneously implanted).

ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary) / ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-1.80725
Number of Samples:2 / 2
Experimental ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary transitional cell carcinoma, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the ovary (subcutaneously implanted).

ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; primary) / ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-1.727088
Number of Samples:13 / 2
Experimental ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary serous cystadenocarcinoma, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the ovary (subcutaneously implanted).

obesity study 48 (overweight; batch 1) / normal blood sample (batch 1)

Relative Expression (log2-ratio):1.3510609
Number of Samples:8 / 15
Experimental obesity study 48 (overweight; batch 1)
Blood samples obtained from overweight subjects (batch 1). Individuals were of a mean age of 26.00 ± 9.02 years and did not suffer of any known organic disease (e.g., endocrine, gastrointestinal, pulmonary, renal, neurologic, or gynecological pathology).
Control normal blood sample (batch 1)
Blood samples obtained from normal weight and healthy subjects (batch 1). Individuals were of a mean age of 26.00 ± 9.02 years and did not suffer of any known organic disease (e.g., endocrine, gastrointestinal, pulmonary, renal, neurologic, or gynecological pathology).

juvenile psoriatic arthritis study 1 / normal PBMC sample

Relative Expression (log2-ratio):1.2469769
Number of Samples:2 / 29
Experimental juvenile psoriatic arthritis study 1
Peripheral blood mononuclear cell (PBMC) samples from children with juvenile psoriatic arthritis. All patients were free of disease modifying antirheumatic drugs.
Control normal PBMC sample
Peripheral blood mononuclear cell (PBMC) samples from healthy children; age (mean ± SD): 10.8 ± 5.3 years.

ovarian tumor study 25 (serous ovarian cancer epithelium) / normal ovarian surface epithelium cell sample

Relative Expression (log2-ratio):1.1404762
Number of Samples:12 / 12
Experimental ovarian tumor study 25 (serous ovarian cancer epithelium)
Laser capture micro-dissected serous ovarian cancer epithelium cells derived from female individuals with primary papillary serous adenocarcinoma of the ovary.
Control normal ovarian surface epithelium cell sample
Normal ovarian surface epithelium cell (OSE) samples isolated from female individuals by laser capture micro-dissection (LCM). Indication for removal of healthy ovaries were others than ovary cancer.

influenza virus study 11 (A/H5N3) / influenza virus study 4 (A/H1N1)

Relative Expression (log2-ratio):-1.1124387
Number of Samples:3 / 3
Experimental influenza virus study 11 (A/H5N3)
Human carcinoma cell line A549 infected with influenza A virus subtype influenza virus A/duck/Malaysia/F119/3/1997(H5N3). Samples were taken 10 hours post-infection.
Control influenza virus study 4 (A/H1N1)
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection.

Organism: Homo sapiens
Gene: 1552449_a_at
Selected probe(set): 1552449_a_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552449_a_at (1552449_a_at) across 6673 perturbations tested by GENEVESTIGATOR:

expO peritoneal cancer study 1 (serous surface papillary carcinoma; metastatic) / expO peritoneal cancer study 1 (papillary serous cystadenocarcinoma; metastatic)

Relative Expression (log2-ratio):2.5489893
Number of Samples:2 / 12
Experimental expO peritoneal cancer study 1 (serous surface papillary carcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary serous surface papillary carcinoma of the peritoneum.
Control expO peritoneal cancer study 1 (papillary serous cystadenocarcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary papillary serous cystadenocarcinoma of the peritoneum.

ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary) / ovarian tumor study 30 (PDX; adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):1.9443817
Number of Samples:2 / 2
Experimental ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary adenocarcinoma, NOS of the ovary (subcutaneously implanted).

pancreatic cancer study 5 (PBMC) / normal PBMC sample

Relative Expression (log2-ratio):1.8783951
Number of Samples:3 / 10
Experimental pancreatic cancer study 5 (PBMC)
Peripheral blood mononuclear cell (PBMC) sample from pancreatic cancer patients.
Control normal PBMC sample
Peripheral blood mononuclear cell (PBMC) samples from healthy individuals.

ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary) / ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-1.816145
Number of Samples:2 / 2
Experimental ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary mixed tumor, malignant, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the ovary (subcutaneously implanted).

ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary) / ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-1.80725
Number of Samples:2 / 2
Experimental ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary transitional cell carcinoma, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the ovary (subcutaneously implanted).

ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; primary) / ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-1.727088
Number of Samples:13 / 2
Experimental ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary serous cystadenocarcinoma, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the ovary (subcutaneously implanted).

obesity study 48 (overweight; batch 1) / normal blood sample (batch 1)

Relative Expression (log2-ratio):1.3510609
Number of Samples:8 / 15
Experimental obesity study 48 (overweight; batch 1)
Blood samples obtained from overweight subjects (batch 1). Individuals were of a mean age of 26.00 ± 9.02 years and did not suffer of any known organic disease (e.g., endocrine, gastrointestinal, pulmonary, renal, neurologic, or gynecological pathology).
Control normal blood sample (batch 1)
Blood samples obtained from normal weight and healthy subjects (batch 1). Individuals were of a mean age of 26.00 ± 9.02 years and did not suffer of any known organic disease (e.g., endocrine, gastrointestinal, pulmonary, renal, neurologic, or gynecological pathology).

juvenile psoriatic arthritis study 1 / normal PBMC sample

Relative Expression (log2-ratio):1.2469769
Number of Samples:2 / 29
Experimental juvenile psoriatic arthritis study 1
Peripheral blood mononuclear cell (PBMC) samples from children with juvenile psoriatic arthritis. All patients were free of disease modifying antirheumatic drugs.
Control normal PBMC sample
Peripheral blood mononuclear cell (PBMC) samples from healthy children; age (mean ± SD): 10.8 ± 5.3 years.

ovarian tumor study 25 (serous ovarian cancer epithelium) / normal ovarian surface epithelium cell sample

Relative Expression (log2-ratio):1.1404762
Number of Samples:12 / 12
Experimental ovarian tumor study 25 (serous ovarian cancer epithelium)
Laser capture micro-dissected serous ovarian cancer epithelium cells derived from female individuals with primary papillary serous adenocarcinoma of the ovary.
Control normal ovarian surface epithelium cell sample
Normal ovarian surface epithelium cell (OSE) samples isolated from female individuals by laser capture micro-dissection (LCM). Indication for removal of healthy ovaries were others than ovary cancer.

influenza virus study 11 (A/H5N3) / influenza virus study 4 (A/H1N1)

Relative Expression (log2-ratio):-1.1124387
Number of Samples:3 / 3
Experimental influenza virus study 11 (A/H5N3)
Human carcinoma cell line A549 infected with influenza A virus subtype influenza virus A/duck/Malaysia/F119/3/1997(H5N3). Samples were taken 10 hours post-infection.
Control influenza virus study 4 (A/H1N1)
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection.