TOP TEN perturbations for 1552509_a_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552509_a_at
Selected probe(set): 1552509_a_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552509_a_at (1552509_a_at) across 6673 perturbations tested by GENEVESTIGATOR:

breast cancer study 15 (inv. dc) / normal breast tissue

Relative Expression (log2-ratio):-5.1259985
Number of Samples:5 / 5
Experimental breast cancer study 15 (inv. dc)
Primary invasive ductal carcinoma tissue sample derived from the breasts of female patients after surgery.
Control normal breast tissue
Tissue samples of the breast from healthy female individuals after breast reduction surgery.

gestational age study 1 (term) / elective termination placenta (1st trim.) tissue

Relative Expression (log2-ratio):4.8253126
Number of Samples:4 / 4
Experimental gestational age study 1 (term)
Term human placenta samples obtained from scheduled uncomplicated C-sections.
Control elective termination placenta (1st trim.) tissue
First trimester placenta samples (45-59 days) obtained from uncomplicated elective termination.

breast cancer study 11 / normal breast tissue

Relative Expression (log2-ratio):-4.399396
Number of Samples:351 / 4
Experimental breast cancer study 11
Tissue samples from female patients with primary invasive breast cancer after surgery .
Control normal breast tissue
Tissue samples of the breast from healthy female individuals after breast reduction mammoplasty.

breast cancer study 16 (mix. inv. dc lc) / adjacent breast tissue

Relative Expression (log2-ratio):-4.0827236
Number of Samples:4 / 27
Experimental breast cancer study 16 (mix. inv. dc lc)
Primary mixed invasive ductal and lobular carcinoma tissue sample derived from the breasts of female patients after surgery.
Control adjacent breast tissue
Histologically normal breast tissue samples obtained from a clinically unaffected site from patients with primary invasive breast cancer.

breast cancer study 16 (inv. dc) / adjacent breast tissue

Relative Expression (log2-ratio):-4.0321627
Number of Samples:22 / 27
Experimental breast cancer study 16 (inv. dc)
Primary invasive ductal carcinoma tissue sample derived from the breasts of female patients after surgery.
Control adjacent breast tissue
Histologically normal breast tissue samples obtained from a clinically unaffected site from patients with primary invasive breast cancer.

breast cancer study 15 (dc is) / normal breast tissue

Relative Expression (log2-ratio):-4.002309
Number of Samples:9 / 5
Experimental breast cancer study 15 (dc is)
Primary ductal carcinoma in situ tissue sample derived from the breasts of female patients after surgery.
Control normal breast tissue
Tissue samples of the breast from healthy female individuals after breast reduction surgery.

breast cancer study 8 (primary) / normal breast tissue

Relative Expression (log2-ratio):-3.9550867
Number of Samples:13 / 4
Experimental breast cancer study 8 (primary)
Human primary infiltrating ductal carcinoma sample of a female patient with breast cancer.
Control normal breast tissue
Normal human breast samples of healthy female individuals.

breast cancer study 10 (stroma) / noncancerous breast stroma tissue

Relative Expression (log2-ratio):-3.8385372
Number of Samples:6 / 6
Experimental breast cancer study 10 (stroma)
Cancerous breast stroma tissue from female patients associated to primary breast infiltrative ductal carcinoma with stromal invasion.
Control noncancerous breast stroma tissue
Noncancerous (normal) tissue cell samples after laser-microdissection from female patients with primary breast infiltrative ductal carcinoma with stromal invasion.

sarcoidosis study 6 (orbital adipose tissue) / normal orbital adipose tissue

Relative Expression (log2-ratio):-3.8175716
Number of Samples:7 / 22
Experimental sarcoidosis study 6 (orbital adipose tissue)
Orbital adipose tissue samples obtained from patients who suffered from sarcoidosis. Biopsies were formalin-fixed and paraffin-embedded.
Control normal orbital adipose tissue
Normal orbital adipose tissue samples. Samples were obtained from subjects with no history of orbital disease at the time of surgery such as fat typically excised and discarded as part of routine blepharoplasty or retrobulbar fat that is snared with the eye during enucleation. Biopsies were formalin-fixed and paraffin-embedded.

rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium) / focal segmental glomerulosclerosis study 9 (glomerulus)

Relative Expression (log2-ratio):-3.7768698
Number of Samples:21 / 10
Experimental rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium)
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from rapidly progressive glomerulonephritis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Donors were positive for ANCA-antibody. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control focal segmental glomerulosclerosis study 9 (glomerulus)
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.