TOP TEN perturbations for 1552566_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552566_at
Selected probe(set): 1552566_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552566_at (1552566_at) across 6672 perturbations tested by GENEVESTIGATOR:

IL-22 study 2 (2d; 200ng/ml) / IL-17 study 2 (2d; 200ng/ml)

Relative Expression (log2-ratio):3.9282274
Number of Samples:3 / 3
Experimental IL-22 study 2 (2d; 200ng/ml)
Reconstructed human epidermis model (RHE; EpiDermTM/MatTek) incubated in assay media supplemented with 200 ng/ml of interleukin 22 (IL-22) for 2 days. Full-thickness human skin model resembles in vivo epidermal architecture.
Control IL-17 study 2 (2d; 200ng/ml)
Reconstructed human epidermis model (RHE; EpiDermTM/MatTek) incubated in assay media supplemented with 200 ng/ml of interleukin 17 (IL-17) for 2 days. Full-thickness human skin model resembles in vivo epidermal architecture.

male infertility study 1 (mJS2) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):-3.3765917
Number of Samples:7 / 8
Experimental male infertility study 1 (mJS2)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

male infertility study 1 (juvenile; Ad+) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):-3.3559933
Number of Samples:5 / 8
Experimental male infertility study 1 (juvenile; Ad+)
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained typical level of A-dark (Ad+) spermatogonial cells.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

expO renal pelvis cancer study 1 (transitional cell carcinoma, NOS; primary) / expO renal pelvis cancer study 1 (papillary transitional cell carcinoma; primary)

Relative Expression (log2-ratio):-3.3354244
Number of Samples:5 / 4
Experimental expO renal pelvis cancer study 1 (transitional cell carcinoma, NOS; primary)
Primary tumor tissue samples obtained from the renal pelvis of patients with transitional cell carcinoma (NOS).
Control expO renal pelvis cancer study 1 (papillary transitional cell carcinoma; primary)
Primary tumor tissue samples obtained from the renal pelvis of patients with papillary transitional cell carcinoma.

male infertility study 1 (mJS5) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):-3.2730255
Number of Samples:8 / 8
Experimental male infertility study 1 (mJS5)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained spermatocytes but no spermatids. Tissue samples were classified based on modified Johnsen score (mJS) as mJS5.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

male infertility study 1 (juvenile; Ad-) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):-3.2230358
Number of Samples:2 / 8
Experimental male infertility study 1 (juvenile; Ad-)
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained very low level of A-dark (Ad-) spermatogonial cells.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

male infertility study 1 (mJS3) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):-3.1891036
Number of Samples:3 / 8
Experimental male infertility study 1 (mJS3)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained Sertoli cells but rarely spermatogonia. Tissue samples were classified based on modified Johnsen score (mJS) as mJS3.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

bladder cancer study 3 / bladder cancer study 1

Relative Expression (log2-ratio):-3.0261354
Number of Samples:3 / 3
Experimental bladder cancer study 3
High grade muscle invasive tumors.
Control bladder cancer study 1
Low grade superficial tumor samples.

psoriasis study 20 (lesional) / psoriasis study 20 (non-lesional)

Relative Expression (log2-ratio):-2.583128
Number of Samples:4 / 4
Experimental psoriasis study 20 (lesional)
Lesional skin punch biopsies derived from patients with chronic plaque psoriasis. 6 mm punch biopsies were obtained under local anesthesia preferentially near the central region of active plaques, except in cases where the center was poorly defined due to an irregular boundary. Regions near the edge of individual plaques were avoided to ensure that uninvolved skin was not included. Patients with one or more psoriasis plaques not limited to the scalp area were enrolled to the study. In case that only one plaque was present, a patient was admitted when that plaque occupied more than 1% of the body surface area. Patients were advised not to apply topical treatments for at least 1 week prior to biopsies and not to use systemic medications for at least 2 weeks prior to sample biopsies. Biopsies were snap-frozen in liquid nitrogen, stored at -80°C.
Control psoriasis study 20 (non-lesional)
Non-lesional skin punch biopsies derived from patients with chronic plaque psoriasis. 6 mm punch biopsies were obtained under local anesthesia from the buttocks and at least 10 cm away from the nearest active psoriasis plaque. Patients with one or more psoriasis plaques not limited to the scalp area were enrolled to the study. In case that only one plaque was present, a patient was admitted when that plaque occupied more than 1% of the body surface area. Patients were advised not to apply topical treatments for at least 1 week prior to biopsies and not to use systemic medications for at least 2 weeks prior to sample biopsies. Biopsies were snap-frozen in liquid nitrogen, stored at -80°C.

expO bladder cancer study 1 (transitional cell carcinoma, NOS; primary) / expO bladder cancer study 1 (papillary transitional cell carcinoma; primary)

Relative Expression (log2-ratio):-2.5049925
Number of Samples:18 / 6
Experimental expO bladder cancer study 1 (transitional cell carcinoma, NOS; primary)
Primary tumor tissue samples obtained from the bladder of patients with transitional cell carcinoma (NOS).
Control expO bladder cancer study 1 (papillary transitional cell carcinoma; primary)
Primary tumor tissue samples obtained from the bladder of patients with papillary transitional cell carcinoma.