TOP TEN perturbations for 1552620_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552620_at
Selected probe(set): 1552620_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552620_at (1552620_at) across 6673 perturbations tested by GENEVESTIGATOR:

engineered skin substitute study 1 (late) / engineered skin substitute study 1 (early)

Relative Expression (log2-ratio):3.2166042
Number of Samples:3 / 2
Experimental engineered skin substitute study 1 (late)
Human skin substitutes tissue samples collected after 14 days in culture.
Control engineered skin substitute study 1 (early)
Human skin substitutes tissue samples collected after 3 days in culture.

atopic dermatitis study 12 (non-lesional; adults) / normal skin tissue (adults)

Relative Expression (log2-ratio):-3.1339464
Number of Samples:20 / 11
Experimental atopic dermatitis study 12 (non-lesional; adults)
Unaffected skin biopsy samples from adult patients (age range 18-73 years) with long-standing atopic dermatitis.
Control normal skin tissue (adults)
Skin biopsy samples from healthy adults (age range 38–57 years).

PMA study 6 (500ng/ml) / vehicle (DME) treated bronchial epithelial cell sample

Relative Expression (log2-ratio):3.0014467
Number of Samples:3 / 17
Experimental PMA study 6 (500ng/ml)
Bronchial epithelial cells (NHBE) treated with tetradecanoylphorbol acetate (500ng/ml; vendor: Sigma / catalog number: P1585 / catalog name: Phorbol 12-myristate 13-acetate [16561-29-8]) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). ATC code:---
Control vehicle (DME) treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) treated with vehicle (DME) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial).

atopic dermatitis study 12 (lesional; adults) / normal skin tissue (adults)

Relative Expression (log2-ratio):-2.9604454
Number of Samples:20 / 11
Experimental atopic dermatitis study 12 (lesional; adults)
Lesional skin biopsy samples from adult patients (age range 18-73 years) with long-standing atopic dermatitis.
Control normal skin tissue (adults)
Skin biopsy samples from healthy adults (age range 38–57 years).

Merkel cell carcinoma study 3 (primary) / normal skin tissue

Relative Expression (log2-ratio):-2.8375864
Number of Samples:19 / 64
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control normal skin tissue
Normal skin samples from healthy donors.

Merkel cell carcinoma study 3 (metastatic) / normal skin tissue

Relative Expression (log2-ratio):-2.757782
Number of Samples:11 / 64
Experimental Merkel cell carcinoma study 3 (metastatic)
Metastatic tumor tissue from different metastatic sites (skin, lymph node, parotid gland) of patients with Merkel cell carcinoma of the skin.
Control normal skin tissue
Normal skin samples from healthy donors.

polyinosinic-polycytidylic acid study 1 (10ug/ml) / vehicle (DME) treated bronchial epithelial cell sample

Relative Expression (log2-ratio):2.7216988
Number of Samples:3 / 17
Experimental polyinosinic-polycytidylic acid study 1 (10ug/ml)
Bronchial epithelial cells (NHBE) treated with polyinosinic-polycytidylic acid (Poly(I:C); 10ug/ml; vendor: InvivoGen / catalog number: tlrl-pic / catalog name: Poly(I:C) High Molecular Weight [31852-29-6]) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). ATC code:
Control vehicle (DME) treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) treated with vehicle (DME) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial).

Rosacea study 1 (ETR) / normal skin tissue

Relative Expression (log2-ratio):2.661336
Number of Samples:14 / 20
Experimental Rosacea study 1 (ETR)
Skin biopsy samples from patients with erythematotelangiectatic rosacea (ETR), diagnosed in accordance with classification system of the American Rosacea Society. Skin biopsies were taken from nasolabial fold.
Control normal skin tissue
Normal skin biopsy samples from healthy individuals.

wound healing study 2 (in vivo) / control skin tissue (in vivo)

Relative Expression (log2-ratio):-2.5255108
Number of Samples:3 / 3
Experimental wound healing study 2 (in vivo)
Skin wound samples obtained by punch biopsy from the edge of the original biopsies after four days. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. To possible remove infiltrating inflammatory cells before RNA isolation the samples were washed in NaCl.
Control control skin tissue (in vivo)
Control non-wounded skin samples obtained by punch biopsy from healthy donors. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. To possible remove infiltrating inflammatory cells before RNA isolation the samples were washed in NaCl.

basal cell carcinoma study 2 / normal skin tissue

Relative Expression (log2-ratio):-2.4963264
Number of Samples:2 / 64
Experimental basal cell carcinoma study 2
Primary tumor tissue from the skin of patients with basal cell carcinoma (BCC).
Control normal skin tissue
Normal skin samples from healthy donors.