TOP TEN perturbations for 1552675_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552675_at
Selected probe(set): 1552675_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552675_at (1552675_at) across 6673 perturbations tested by GENEVESTIGATOR:

dengue fever study 10 (DHF) / normal naive CD8 T cell sample

Relative Expression (log2-ratio):-1.4724121
Number of Samples:2 / 5
Experimental dengue fever study 10 (DHF)
Activated CD8 T cells derived from peripheral blood mononuclear cells (PBMCs) of Thai individuals with Dengue hemorrhagic fever (DF) characterized by the WHO 1997. FACS-sorted CD3+, CD8+, HLA_DR+, and CD38+ effector CD8 T subtype cells were used for analysis.
Control normal naive CD8 T cell sample
Normal naive CD8 T cells derived from peripheral blood mononuclear cells (PBMCs) of healthy Thai individuals. FACS-sorted CD3+, CD8+, CD45RA+, and CCR7+ naive CD8 T subtype cells were used for analysis.

ovarian tumor study 16 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):1.3137445
Number of Samples:3 / 5
Experimental ovarian tumor study 16
Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue.

exercise study 33 (OT; fast twitch; post-exerc.) / exercise study 33 (YT; fast twitch; post-exerc.)

Relative Expression (log2-ratio):1.2767386
Number of Samples:4 / 6
Experimental exercise study 33 (OT; fast twitch; post-exerc.)
Fast twitch myosin heavy chain muscle fibers (MHC) IIa were obtained from vastus lateralis muscle. Biopsies were taken from old trained (OT) women (85±1 years) 4 hours after the 36th (last) exercise session. Participants underwent 12 weeks of progressive resistance training including 36 training sessions (3 days/week) with three sets of 10 bilateral knee extensions at 70–75% of their one-repetition maximum (1 RM). Fibers were separated under the light microscope and MHC isoform was determinated based on SDS-PAGE analysis. Exclusion criteria: acute/chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin-dependent diabetes, abnormal blood, or urine chemistries, arthritis, a history of neuromuscular problems, tobacco smoking. Individuals, that had ever completed any formal exercise programs or physical activity outside of their activities of daily living, were excluded as well.
Control exercise study 33 (YT; fast twitch; post-exerc.)
Fast twitch myosin heavy chain muscle fibers (MHC) IIa were obtained from vastus lateralis muscle. Biopsies were taken from young trained (YT) women (23±2 years old) 4 hours after the 36th (last) exercise session. Participants underwent 12 weeks of progressive resistance training including 36 training sessions (3 days/week) with three sets of 10 bilateral knee extensions at 70–75% of their one-repetition maximum (1 RM). Fibers were separated under the light microscope and MHC isoform was determinated based on SDS-PAGE analysis. Exclusion criteria: acute/chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin-dependent diabetes, abnormal blood, or urine chemistries, arthritis, a history of neuromuscular problems, tobacco smoking. Individuals, that had ever completed any formal exercise programs or physical activity outside of their activities of daily living, were excluded as well.

glioma study 16 (LN-229) / normal astrocyte sample

Relative Expression (log2-ratio):1.1264935
Number of Samples:2 / 3
Experimental glioma study 16 (LN-229)
Human glioma cell line LN229 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

Sjogren's syndrome study 11 (CD8 TEMRA) / normal peripheral blood CD8 memory T-cell sample

Relative Expression (log2-ratio):-1.0124435
Number of Samples:6 / 6
Experimental Sjogren's syndrome study 11 (CD8 TEMRA)
Terminally differentiated effector memor CD8 T-cells (TEMRA) isolated from peripheral blood of patients with primary Sjogren's syndrome (pSS). Patient characteristics: 65.33 ± 8.19y; 6 females; ESSDAI 1.33 ± 1.63; 4 female RF positive; 4 female RO_SSA positive; 3 female LA_SSB positive; 6 female ANA positive. Exclusion criteria: patients who were being treated with moderate to high doses of corticosteroids, immunosuppressants or biological agents. FACS markers: CD3+CD8+CD45RA+CCR7-
Control normal peripheral blood CD8 memory T-cell sample
Terminally differentiated effector memor CD8 T-cells (TEMRA) isolated from peripheral blood of healthy control subjects who did not have autoimmune diseases or were not receiving any drugs. Donor characteristics: age 43.83±6.55 year; 6 females. FACS markers: CD3+CD8+CD45RA+CCR7-

Sjogren's syndrome study 11 (CD4 TCM) / normal peripheral blood CD4 central memory T-cell sample

Relative Expression (log2-ratio):-1.0091591
Number of Samples:6 / 6
Experimental Sjogren's syndrome study 11 (CD4 TCM)
Central memory CD4 T-cells (TCM) isolated from peripheral blood of patients with primary Sjogren's syndrome (pSS). Patient characteristics: 64.67 ± 15.93y; 6 patients; ESSDAI 0.17 ± 0.41; 3 patients RF positive; 3 patients RO_SSA positive; 1 patient LA_SSB positive; 6 patients ANA positive. Exclusion criteria: patients who were being treated with moderate to high doses of corticosteroids, immunosuppressants or biological agents. FACS markers: CD3+CD4+CD45RA-CCR7-
Control normal peripheral blood CD4 central memory T-cell sample
Peripheral blood CD4 central memory T-cell samples (TCM) derived from healthy control subjects who did not have autoimmune diseases or were not receiving any drugs. Donor characteristics: age 43.33±5.72 year; 6 females. FACS markers: CD3+CD4+CD45RA-CCR7+

psoriasis study 24 (lesional; ustekinumab; 12wk; 45mg; responder) / psoriasis study 24 (lesional; ustekinumab; 12wk; 45mg; non-responder)

Relative Expression (log2-ratio):-0.96033764
Number of Samples:16 / 2
Experimental psoriasis study 24 (lesional; ustekinumab; 12wk; 45mg; responder)
Lesional skin punch biopsies derived from patients with moderate-to-severe psoriasis at 12 week after treatment with 45 mg ustekinumab and assigned as responders. Ustekinumab was administered subcutaneously in dose of 45 mg at week 0 and 4. Responders are patients who achieved ≥75% improvement from baseline in Psoriasis Area and Severity Index (PASI75) at week 12. Lesional skin samples were isolated from a representative psoriatic target lesion (≥ 3cm). Patients participated in a phase 3 of Psoriasis Trial ACCEPT. ATC code:
Control psoriasis study 24 (lesional; ustekinumab; 12wk; 45mg; non-responder)
Lesional skin punch biopsies derived from patients with moderate-to-severe psoriasis at 12 week after treatment with 45 mg ustekinumab and assigned as non-responders. Ustekinumab was administered subcutaneously in dose of 45 mg at week 0 and 4. Non-responders are patients who did not achieve ≥75% improvement from baseline in Psoriasis Area and Severity Index (PASI75) at week 12. Lesional skin samples were isolated from a representative psoriatic target lesion (≥ 3cm). Patients participated in a phase 3 of Psoriasis Trial ACCEPT. ATC code:

Langerhans cell histiocytosis study 2 (unifocal) / normal epidermal Langerhans cell sample

Relative Expression (log2-ratio):0.96001434
Number of Samples:8 / 10
Experimental Langerhans cell histiocytosis study 2 (unifocal)
Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with unifocal, single system disease (bone lesion).
Control normal epidermal Langerhans cell sample
Normal epidermal Langerhans cells (CD207+) were isolated from skin of children donors (age < 18 years). The Langerhans cells were isolated from presumably healthy tissue.

atopic dermatitis study 21 (non-lesional; whole skin) / normal skin tissue

Relative Expression (log2-ratio):0.90635014
Number of Samples:5 / 6
Experimental atopic dermatitis study 21 (non-lesional; whole skin)
Non-lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal skin tissue
Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

ulcerative colitis study 17 (5-ASA / AZA) / ulcerative colitis study 17 (5-ASA)

Relative Expression (log2-ratio):0.8527632
Number of Samples:2 / 2
Experimental ulcerative colitis study 17 (5-ASA / AZA)
Mucosa tissue from sigmoid colon derived from patients with ulcerative colitis treated with mesalazine (5-ASA) in combination with azathioprine (AZA). Biopsies were collected from non-inflamed tissue and histological examination showed no cellular infiltration or tissue damage. Ulcerative colitis (UC) was diagnosed based on endoscopic, histological and radiological criteria and based on a permanent, colon exclusive, inflammation state. All patients showed mild to active disease state (colitis activity index from 2 to 7) and received no antibiotic therapy at least in the last 6 months before investigation. All patients investigated are UC discordant twins.
Control ulcerative colitis study 17 (5-ASA)
Mucosa tissue from sigmoid colon derived from patients with ulcerative colitis treated with mesalazine (5-ASA). Biopsies were collected from non-inflamed tissue and histological examination showed no cellular infiltration or tissue damage. Ulcerative colitis (UC) was diagnosed based on endoscopic, histological and radiological criteria and based on a permanent, colon exclusive, inflammation state. All patients showed mild to active disease state (colitis activity index from 2 to 7) and received no antibiotic therapy at least in the last 6 months before investigation. All patients investigated are UC discordant twins.