TOP TEN perturbations for 1552731_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1552731_at
Selected probe(set): 1552732_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1552731_at (1552732_at) across 6537 perturbations tested by GENEVESTIGATOR:
basal cell carcinoma study 3 / normal epidermal keratinocytes
Relative Expression (log2-ratio):6.8908043Number of Samples:4 / 2
Experimental | basal cell carcinoma study 3 |
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC). | |
Control | normal epidermal keratinocytes |
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37°C in humidified air containing 5% CO2. |
myotonic dystrophy study 4 (deltoid muscle; DM-like) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):3.831685Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (deltoid muscle; DM-like) |
Deltoid muscle biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (biceps brachii; DM2) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):3.432105Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (biceps brachii; DM2) |
Biceps brachii biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
Becker muscular dystrophy study 3 (biceps brachii) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):3.4307175Number of Samples:3 / 3
Experimental | Becker muscular dystrophy study 3 (biceps brachii) |
Biceps brachii biopsies obtained from patients with Becker muscular dystrophy (BMD). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (deltoid muscle; DM2) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):3.384945Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (deltoid muscle; DM2) |
Deltoid muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
endothelin 1 study 1 / normal iPSC-derived cardiomyocyte sample
Relative Expression (log2-ratio):3.1803856Number of Samples:3 / 3
Experimental | endothelin 1 study 1 |
Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) treated with 10nM endothelin 1 (ET-1) for 18hours. These cardiomyocytes are a highly pure ventricular population established as having functional properties similar to adult human cardiomyocytes. All iPSC-CMs were obtained from one single batch of cells. After two days of recovery, the cells were cultured in William’s E medium supplemented with Cocktail B (1:25) from the Hepatocyte Maintenance Supplement Pack. After an additional 11 days of recovery, cells were stimulated for 18 h with 10nM ET-1. ET-1 is a potent vasoconstrictor and a well established modulator of cardiac hypertrophy in humans. ATC code:--- | |
Control | normal iPSC-derived cardiomyocyte sample |
Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs). These cardiomyocytes are a highly pure ventricular population established as having functional properties similar to adult human cardiomyocytes. All iPSC-CMs were obtained from one single batch of cells. The cells were cultured in William’s E medium supplemented with Cocktail B (1:25) from the Hepatocyte Maintenance Supplement Pack. |
kidney transplantation study 9 (late) / normal kidney transplant
Relative Expression (log2-ratio):3.1346698Number of Samples:2 / 13
Experimental | kidney transplantation study 9 (late) |
Human renal allograft biopsies from deceased donors obtained 24 months after transplantation. | |
Control | normal kidney transplant |
Human renal allograft biopsies from deceased donors obtained at implantation prior to revascularization. |
rheumatoid arthritis study 27 / normal synovial membrane tissue
Relative Expression (log2-ratio):-3.1345787Number of Samples:16 / 7
Experimental | rheumatoid arthritis study 27 |
Synovial membrane samples from end-stage rheumatoid arthritis patients undergoing surgery. | |
Control | normal synovial membrane tissue |
Synovial membrane samples obtained by fine-needle arthroscopy from healthy subjects. |
myotonic dystrophy study 4 (biceps brachii; DM1) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):3.0808191Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (biceps brachii; DM1) |
Biceps brachii biopsies obtained from patients with myotonic dystrophy type 1 (DM1). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (biceps brachii; DM-like) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):3.0743484Number of Samples:9 / 3
Experimental | myotonic dystrophy study 4 (biceps brachii; DM-like) |
Biceps brachii biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |