TOP TEN perturbations for 1552731_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552731_at
Selected probe(set): 1552732_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552731_at (1552732_at) across 6537 perturbations tested by GENEVESTIGATOR:

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):6.8908043
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37°C in humidified air containing 5% CO2.

myotonic dystrophy study 4 (deltoid muscle; DM-like) / normal skeletal muscle tisuue (fetal)

Relative Expression (log2-ratio):3.831685
Number of Samples:3 / 3
Experimental myotonic dystrophy study 4 (deltoid muscle; DM-like)
Deltoid muscle biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion).
Control normal skeletal muscle tisuue (fetal)
Commercially purchased normal fetal skeletal muscle tissue samples.

myotonic dystrophy study 4 (biceps brachii; DM2) / normal skeletal muscle tisuue (fetal)

Relative Expression (log2-ratio):3.432105
Number of Samples:3 / 3
Experimental myotonic dystrophy study 4 (biceps brachii; DM2)
Biceps brachii biopsies obtained from patients with myotonic dystrophy type 2 (DM2).
Control normal skeletal muscle tisuue (fetal)
Commercially purchased normal fetal skeletal muscle tissue samples.

Becker muscular dystrophy study 3 (biceps brachii) / normal skeletal muscle tisuue (fetal)

Relative Expression (log2-ratio):3.4307175
Number of Samples:3 / 3
Experimental Becker muscular dystrophy study 3 (biceps brachii)
Biceps brachii biopsies obtained from patients with Becker muscular dystrophy (BMD).
Control normal skeletal muscle tisuue (fetal)
Commercially purchased normal fetal skeletal muscle tissue samples.

myotonic dystrophy study 4 (deltoid muscle; DM2) / normal skeletal muscle tisuue (fetal)

Relative Expression (log2-ratio):3.384945
Number of Samples:3 / 3
Experimental myotonic dystrophy study 4 (deltoid muscle; DM2)
Deltoid muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2).
Control normal skeletal muscle tisuue (fetal)
Commercially purchased normal fetal skeletal muscle tissue samples.

endothelin 1 study 1 / normal iPSC-derived cardiomyocyte sample

Relative Expression (log2-ratio):3.1803856
Number of Samples:3 / 3
Experimental endothelin 1 study 1
Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) treated with 10nM endothelin 1 (ET-1) for 18hours. These cardiomyocytes are a highly pure ventricular population established as having functional properties similar to adult human cardiomyocytes. All iPSC-CMs were obtained from one single batch of cells. After two days of recovery, the cells were cultured in William’s E medium supplemented with Cocktail B (1:25) from the Hepatocyte Maintenance Supplement Pack. After an additional 11 days of recovery, cells were stimulated for 18 h with 10nM ET-1. ET-1 is a potent vasoconstrictor and a well established modulator of cardiac hypertrophy in humans. ATC code:---
Control normal iPSC-derived cardiomyocyte sample
Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs). These cardiomyocytes are a highly pure ventricular population established as having functional properties similar to adult human cardiomyocytes. All iPSC-CMs were obtained from one single batch of cells. The cells were cultured in William’s E medium supplemented with Cocktail B (1:25) from the Hepatocyte Maintenance Supplement Pack.

kidney transplantation study 9 (late) / normal kidney transplant

Relative Expression (log2-ratio):3.1346698
Number of Samples:2 / 13
Experimental kidney transplantation study 9 (late)
Human renal allograft biopsies from deceased donors obtained 24 months after transplantation.
Control normal kidney transplant
Human renal allograft biopsies from deceased donors obtained at implantation prior to revascularization.

rheumatoid arthritis study 27 / normal synovial membrane tissue

Relative Expression (log2-ratio):-3.1345787
Number of Samples:16 / 7
Experimental rheumatoid arthritis study 27
Synovial membrane samples from end-stage rheumatoid arthritis patients undergoing surgery.
Control normal synovial membrane tissue
Synovial membrane samples obtained by fine-needle arthroscopy from healthy subjects.

myotonic dystrophy study 4 (biceps brachii; DM1) / normal skeletal muscle tisuue (fetal)

Relative Expression (log2-ratio):3.0808191
Number of Samples:3 / 3
Experimental myotonic dystrophy study 4 (biceps brachii; DM1)
Biceps brachii biopsies obtained from patients with myotonic dystrophy type 1 (DM1).
Control normal skeletal muscle tisuue (fetal)
Commercially purchased normal fetal skeletal muscle tissue samples.

myotonic dystrophy study 4 (biceps brachii; DM-like) / normal skeletal muscle tisuue (fetal)

Relative Expression (log2-ratio):3.0743484
Number of Samples:9 / 3
Experimental myotonic dystrophy study 4 (biceps brachii; DM-like)
Biceps brachii biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion).
Control normal skeletal muscle tisuue (fetal)
Commercially purchased normal fetal skeletal muscle tissue samples.