TOP TEN perturbations for 1552755_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552755_at
Selected probe(set): 1552755_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552755_at (1552755_at) across 6673 perturbations tested by GENEVESTIGATOR:

nephroblastoma study 2 / normal kidney tissue

Relative Expression (log2-ratio):-3.5212069
Number of Samples:4 / 3
Experimental nephroblastoma study 2
Tumor tissue samples from the kidney of patients with Wilms’ tumor.
Control normal kidney tissue
Normal adult kidney tissue samples.

collecting duct carcinoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):-3.1940393
Number of Samples:2 / 3
Experimental collecting duct carcinoma study 1
Tumor tissue samples from the kidney of patients with collecting duct carcinoma (CDC).
Control normal kidney tissue
Normal adult kidney tissue samples.

rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium) / focal segmental glomerulosclerosis study 9 (glomerulus)

Relative Expression (log2-ratio):2.7415047
Number of Samples:21 / 10
Experimental rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium)
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from rapidly progressive glomerulonephritis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Donors were positive for ANCA-antibody. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control focal segmental glomerulosclerosis study 9 (glomerulus)
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.

IFNa-2a study 1 / normal monocyte sample

Relative Expression (log2-ratio):2.3886204
Number of Samples:7 / 7
Experimental IFNa-2a study 1
Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml IFNα2a in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and they were sorted from remaining peripheral blood leukocytes by CD14 labeling.
Control normal monocyte sample
Monocyte samples isolated from healthy subjects. Peripheral blood monocytes were isolated immediately after drawing blood by depletion from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocyte by CD14 labeling.

clear cell renal cell carcinoma study 4 (stage 3) / normal kidney tissue

Relative Expression (log2-ratio):-2.304863
Number of Samples:14 / 69
Experimental clear cell renal cell carcinoma study 4 (stage 3)
Primary tumor tissue from patients with stage 3 clear cell renal cell carcinoma (ccRCC).
Control normal kidney tissue
Normal kidney tissue samples obtained from healthy individuals.

clear cell renal cell carcinoma study 3 (obese; smoker) / normal kidney tissue

Relative Expression (log2-ratio):-2.292985
Number of Samples:7 / 25
Experimental clear cell renal cell carcinoma study 3 (obese; smoker)
Tumor tissue from patients with clear cell renal cell carcinoma (ccRCC).Patients were smokers and had a BMI > 30 kg/m2. Patients with late T4 stage and grade 4 tumors were excluded.
Control normal kidney tissue
Normal kidney tissue samples obtained from healthy, non-smoking and non-obese individuals.

renal cell carcinoma study 5 (papillary type) / normal kidney tissue

Relative Expression (log2-ratio):-2.2689457
Number of Samples:19 / 3
Experimental renal cell carcinoma study 5 (papillary type)
Tumor tissue samples from the kidney of patients with papillary renal cell carcinoma (pRCC).
Control normal kidney tissue
Normal adult kidney tissue samples.

MCF-7:2A / MCF-7

Relative Expression (log2-ratio):2.2070637
Number of Samples:4 / 4
Experimental MCF-7:2A
Long-term estrogen deprived breast cancer cells MCF-7, which are resistant to estrogen-deprivation and therefore show an aromatase inhibitor resistantance. MCF-7 is human metastatic cancer cell line derived from the pleural effusion of a patient with adenocarcinoma of the breast. Parental cell line:: MCF-7 Cellosaurus code:
Control MCF-7
Human metastatic cancer cell line derived from the pleural effusion of a patient (69 years old, caucasian) with adenocarcinoma of the breast. Synonyms:MCF 7; MCF.7; MCF7; Michigan Cancer Foundation 7; ssMCF7; MCF7/WT; IBMF-7; MCF7-CTRL Cellosaurus code:

renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue

Relative Expression (log2-ratio):-2.1198435
Number of Samples:4 / 3
Experimental renal cell carcinoma study 6 (chromophobe type)
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC).
Control normal kidney tissue
Normal adult kidney tissue samples.

kidney transplantation study 20 (AR+CAN) / kidney transplantation study 20 (no rejection)

Relative Expression (log2-ratio):-2.1161547
Number of Samples:7 / 21
Experimental kidney transplantation study 20 (AR+CAN)
Renal allograft biopsies derived from kidney transplant patients showing acute rejection (AR) and chronic allograft nephropathy (CAN). Biopsies were obtained by a 16-gauge biopsy needle.
Control kidney transplantation study 20 (no rejection)
Non-rejecting renal allograft biopsies derived from kidney transplant patients. Biopsies were obtained by a 16-gauge biopsy needle.