TOP TEN perturbations for 1552787_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1552787_at
Selected probe(set): 1552787_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1552787_at (1552787_at) across 6674 perturbations tested by GENEVESTIGATOR:
E. coli study 2 / unstimulated, normal monocyte-derived macrophage sample
Relative Expression (log2-ratio):3.0418634Number of Samples:5 / 7
Experimental | E. coli study 2 |
Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours with 2.5 × 105 heat-killed E. coli. | |
Control | unstimulated, normal monocyte-derived macrophage sample |
Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours unstimulated. |
rheumatoid arthritis study 31 / IFNa-2a study 1
Relative Expression (log2-ratio):-3.0335922Number of Samples:4 / 7
Experimental | rheumatoid arthritis study 31 |
Monocyte samples isolated from patients with rheumatoid arthritis (RA). Monocytes from whole blood were depleted from granulocytes by CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. Patients fulfilled the revised American College of Rheumatology criteria (ACR) for RA. | |
Control | IFNa-2a study 1 |
Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml IFNα2a in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and they were sorted from remaining peripheral blood leukocytes by CD14 labeling. |
IFNa-2a study 1 / unstimulated monocyte sample
Relative Expression (log2-ratio):2.979373Number of Samples:7 / 11
Experimental | IFNa-2a study 1 |
Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml IFNα2a in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and they were sorted from remaining peripheral blood leukocytes by CD14 labeling. | |
Control | unstimulated monocyte sample |
Monocyte samples isolated from healthy donors and incubated in whole blood for 1.5 hour without any stimulation. Following incubation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. |
IFNa-2a study 1 / normal monocyte sample
Relative Expression (log2-ratio):2.7614717Number of Samples:7 / 7
Experimental | IFNa-2a study 1 |
Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml IFNα2a in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and they were sorted from remaining peripheral blood leukocytes by CD14 labeling. | |
Control | normal monocyte sample |
Monocyte samples isolated from healthy subjects. Peripheral blood monocytes were isolated immediately after drawing blood by depletion from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocyte by CD14 labeling. |
E. coli study 1 / unstimulated, normal monocyte-derived macrophage sample
Relative Expression (log2-ratio):2.6839876Number of Samples:12 / 16
Experimental | E. coli study 1 |
Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours with 2.5 × 105 heat-killed E. coli. | |
Control | unstimulated, normal monocyte-derived macrophage sample |
Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours unstimulated. |
cutaneous T-cell lymphoma study 1 (tumor phase) / normal skin tissue
Relative Expression (log2-ratio):2.6161528Number of Samples:4 / 8
Experimental | cutaneous T-cell lymphoma study 1 (tumor phase) |
Lesional skin biopsies from patients with cutaneous T-cell lymphoma in the tumor phase (extranodal). | |
Control | normal skin tissue |
Skin biopsies from healthy individuals. |
influenza virus study 9 (A/H9N2) / influenza virus study 4 (A/H1N1)
Relative Expression (log2-ratio):2.508315Number of Samples:3 / 3
Experimental | influenza virus study 9 (A/H9N2) |
Human carcinoma cell line A549 infected with influenza A virus subtype A/Duck/Malaysia/01 (H9N2). Samples were taken 10 hours post-infection. | |
Control | influenza virus study 4 (A/H1N1) |
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection. |
rheumatoid arthritis study 31 / IFN-g study 11
Relative Expression (log2-ratio):-2.5055904Number of Samples:4 / 7
Experimental | rheumatoid arthritis study 31 |
Monocyte samples isolated from patients with rheumatoid arthritis (RA). Monocytes from whole blood were depleted from granulocytes by CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. Patients fulfilled the revised American College of Rheumatology criteria (ACR) for RA. | |
Control | IFN-g study 11 |
Monocyte samples isolated from donors and stimulated in vitro by 100 ng/ml IFNγ in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. |
IFN-g study 11 / unstimulated monocyte sample
Relative Expression (log2-ratio):2.4513712Number of Samples:7 / 11
Experimental | IFN-g study 11 |
Monocyte samples isolated from donors and stimulated in vitro by 100 ng/ml IFNγ in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. | |
Control | unstimulated monocyte sample |
Monocyte samples isolated from healthy donors and incubated in whole blood for 1.5 hour without any stimulation. Following incubation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. |
influenza virus study 11 (A/H5N3) / influenza virus study 4 (A/H1N1)
Relative Expression (log2-ratio):2.4145937Number of Samples:3 / 3
Experimental | influenza virus study 11 (A/H5N3) |
Human carcinoma cell line A549 infected with influenza A virus subtype influenza virus A/duck/Malaysia/F119/3/1997(H5N3). Samples were taken 10 hours post-infection. | |
Control | influenza virus study 4 (A/H1N1) |
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection. |