TOP TEN perturbations for 1552789_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552789_at
Selected probe(set): 208942_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552789_at (208942_s_at) across 6673 perturbations tested by GENEVESTIGATOR:

brefeldin A study 1 (0.5ug/ml; HCT 116) / untreated HCT 116 cell sample

Relative Expression (log2-ratio):3.303586
Number of Samples:3 / 3
Experimental brefeldin A study 1 (0.5ug/ml; HCT 116)
Human colon carcinoma cell line HCT116 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:---
Control untreated HCT 116 cell sample
Human colon carcinoma cell line HCT116 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS.

brefeldin A study 1 (0.5ug/ml; p53HCT116) / untreated p53HCT116 cell sample

Relative Expression (log2-ratio):3.2093172
Number of Samples:2 / 3
Experimental brefeldin A study 1 (0.5ug/ml; p53HCT116)
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:---
Control untreated p53HCT116 cell sample
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS.

esophageal adenocarcinoma study 1 / normal esophageal epithelium sample

Relative Expression (log2-ratio):2.0325737
Number of Samples:20 / 18
Experimental esophageal adenocarcinoma study 1
Esophageal adenocarcinoma (EAC) samples of affected epithelium recovered by laser capture microdissection technique.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

ovarian tumor study 17 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):1.981842
Number of Samples:9 / 10
Experimental ovarian tumor study 17
Human epithelial tumor cell samples from the ovary of patients with primary clear cell carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue from donors with non-cancerous, benign gynecological diseases.

esophageal squamous cell carcinoma study 1 / normal esophageal epithelium sample

Relative Expression (log2-ratio):1.8402653
Number of Samples:8 / 18
Experimental esophageal squamous cell carcinoma study 1
Esophageal squamous cell carcinoma (ESCC) biopsy samples from chemotherapy-naive patients with histological grading G1 (well differentiated) and UICC stage II and III, which undergone esophagectomy.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

B-cell activation study 1 / unstimulated B-cell sample

Relative Expression (log2-ratio):-1.8006763
Number of Samples:4 / 4
Experimental B-cell activation study 1
Tonsillar B-cell samples stimulated with 10 µg/mL anti-CD40 antibody and 100 U/mL recombinant human IL-4. Cells were cultured under TH2-skewing conditions for 24 hours.
Control unstimulated B-cell sample
Unstimulated tonsillar B-cells cultured for 24 hours.

T-cell activation study 4 / normal resting T-cell sample

Relative Expression (log2-ratio):-1.7645664
Number of Samples:2 / 2
Experimental T-cell activation study 4
T-cell samples antiCD3 activated for 30hrs.
Control normal resting T-cell sample
T cells resting for 30h.

sickle cell disease study 2 (Pax) / normal blood sample

Relative Expression (log2-ratio):1.727932
Number of Samples:5 / 5
Experimental sickle cell disease study 2 (Pax)
Whole blood samples of patients with sickle cell disease collected in PAXgene tubes. RNA was extracted using the PAXgene™ Blood RNA System Kit followed by an on-column DNase digestion step.
Control normal blood sample
Whole blood samples of healthy volunteers collected in PAXgene tubes. RNA was extracted using the PAXgeneTM Blood RNA System Kit followed by an on-column DNase digestion step.

Huntington's disease study 11 / normal dermal fibroblast cell sample

Relative Expression (log2-ratio):1.6874695
Number of Samples:6 / 3
Experimental Huntington's disease study 11
Primary dermal fibroblast cell samples isolated from male subjects with Huntington's disease (HD). Subjects with inflammatory or infective conditions were excluded. One sample of HD fibroblast cells (ID:GM04799) was purchased from the Coriell Cell Repository. Cells were cultured in MEM medium supplemented with 10% FBS and antibiotics. Cells were used at passage 8-10 and harvested by trypsin treatment.
Control normal dermal fibroblast cell sample
Primary dermal fibroblast cell samples isolated from healthy male subjects. Cells were cultured in MEM medium supplemented with 10% FBS and antibiotics. Cells were used at passage 8-10 and harvested by trypsin treatment.

sarcoidosis study 6 (orbital adipose tissue) / normal orbital adipose tissue

Relative Expression (log2-ratio):-1.6339703
Number of Samples:7 / 22
Experimental sarcoidosis study 6 (orbital adipose tissue)
Orbital adipose tissue samples obtained from patients who suffered from sarcoidosis. Biopsies were formalin-fixed and paraffin-embedded.
Control normal orbital adipose tissue
Normal orbital adipose tissue samples. Samples were obtained from subjects with no history of orbital disease at the time of surgery such as fat typically excised and discarded as part of routine blepharoplasty or retrobulbar fat that is snared with the eye during enucleation. Biopsies were formalin-fixed and paraffin-embedded.