TOP TEN perturbations for 1552816_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552816_at
Selected probe(set): 1552816_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552816_at (1552816_at) across 6593 perturbations tested by GENEVESTIGATOR:

ovarian tumor study 11 (borderline) / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):1.5513687
Number of Samples:8 / 6
Experimental ovarian tumor study 11 (borderline)
Human microdissected tumor cells from the ovary of patients with low-malignant (borderline) tumors of the ovary.
Control normal ovarian surface epithelial cell sample
Human microdissected ovarian surface epithelial cell sample from the ovary of healthy individuals.

rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium) / focal segmental glomerulosclerosis; minimal change disease study 5 (tubulointerstitium)

Relative Expression (log2-ratio):-1.4252911
Number of Samples:21 / 4
Experimental rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium)
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from rapidly progressive glomerulonephritis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Donors were positive for ANCA-antibody. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control focal segmental glomerulosclerosis; minimal change disease study 5 (tubulointerstitium)
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis and minimal change disease. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.

ovarian tumor study 11 (high grade) / ovarian tumor study 11 (borderline)

Relative Expression (log2-ratio):-1.4252353
Number of Samples:22 / 8
Experimental ovarian tumor study 11 (high grade)
Human microdissected tumor cells from the ovary of patients with high grade serous carcinoma.
Control ovarian tumor study 11 (borderline)
Human microdissected tumor cells from the ovary of patients with low-malignant (borderline) tumors of the ovary.

rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 2 / focal segmental glomerulosclerosis; minimal change disease study 2

Relative Expression (log2-ratio):-1.2857404
Number of Samples:21 / 4
Experimental rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 2
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from rapidly progressive glomerulonephritis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Donors were positive for ANCA-antibody. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist..
Control focal segmental glomerulosclerosis; minimal change disease study 2
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis and minimal change disease. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.

diabetic nephropathy study 13 (tubulointerstitium) / focal segmental glomerulosclerosis; minimal change disease study 5 (tubulointerstitium)

Relative Expression (log2-ratio):-1.2811446
Number of Samples:7 / 4
Experimental diabetic nephropathy study 13 (tubulointerstitium)
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from diabetic nephropathy. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control focal segmental glomerulosclerosis; minimal change disease study 5 (tubulointerstitium)
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis and minimal change disease. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.

nutlin-3 study 2 (control vector; 10uM) / vehicle treated MCF-7-con cell sample

Relative Expression (log2-ratio):1.2752981
Number of Samples:6 / 3
Experimental nutlin-3 study 2 (control vector; 10uM)
Human breast adenocarcinoma cells MCF-7 expressing wild type p53, stably transfected with control empty vector pSUPER, treated with nutlin-3 (10 uM) for 48 hours. Cells were cultured in RPMI-1640 medium supplemented with 10% heat inactivated FBS and 50 U/ml of penicillin, 50 ug/ml of streptomycin. ATC code:---
Control vehicle treated MCF-7-con cell sample
Human breast adenocarcinoma cells MCF-7 expressing wild type p53 stably transfected with control empty vector pSUPER, vehicle treated with DMSO (0.1%) for 48 hours. Cells were cultured in RPMI-1640 medium supplemented with 10% heat inactivated FBS and 50 U/ml of penicillin, 50 ug/ml of streptomycin.

ovarian tumor study 26 (serous carcinoma; metastase; peritoneum) / ovarian tumor study 26 (serous carcinoma; borderline; primary)

Relative Expression (log2-ratio):-1.1761265
Number of Samples:15 / 30
Experimental ovarian tumor study 26 (serous carcinoma; metastase; peritoneum)
Metastatic tumor tissue sample obtained from the peritoneum of female patients with primary serous cystadenocarcinoma of the ovary.
Control ovarian tumor study 26 (serous carcinoma; borderline; primary)
Ovarian tissue samples from female patients with primary serous cystadenoma with low malignant potential (borderline).

focal segmental glomerulosclerosis; minimal change disease study 2 / diabetic nephropathy study 2

Relative Expression (log2-ratio):1.1609731
Number of Samples:4 / 7
Experimental focal segmental glomerulosclerosis; minimal change disease study 2
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis and minimal change disease. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control diabetic nephropathy study 2
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from diabetic nephropathy. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.

estradiol; cicloheximide study 1 / vehicle (DMSO) treated MCF-7 cell sample

Relative Expression (log2-ratio):1.1446562
Number of Samples:4 / 4
Experimental estradiol; cicloheximide study 1
MCF7 breast cancer cells were treated with cicloheximide (10 ug/ml) for 1 hour before hormonal treatment with 17{beta}-estradiol (E2, 25 nM) for 24 hours. ATC code:
Control vehicle (DMSO) treated MCF-7 cell sample
MCF7 breast cancer cells treated with vehicle DMSO (0.1%) for 1h and subsequently with vehicle (0.1% ethanol) for 24h.

glioma study 17 ( small cell glioblastoma; unsorted) / non-tumor cortical tissue

Relative Expression (log2-ratio):-1.1349874
Number of Samples:2 / 4
Experimental glioma study 17 ( small cell glioblastoma; unsorted)
Brain cells isolated from high grade small cell glioblastoma (grade IV). Tumor tissue was dissociated using enzymatic treatment and all cells were used for RNA isolation. Patients were 56 ± 3 years old males.
Control non-tumor cortical tissue
Cortical tissue obtained from patients with epilepsy, but without any manifested brain cancer. The tissue was dissociated using enzymatic treatment, but all brain cell types were used for analyses.