TOP TEN perturbations for 1552935_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552935_at
Selected probe(set): 1552935_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552935_at (1552935_at) across 6673 perturbations tested by GENEVESTIGATOR:

PMA study 2 / mock treated MONO-MAC-6 cell sample

Relative Expression (log2-ratio):1.9418583
Number of Samples:3 / 2
Experimental PMA study 2
MONO-MAC-6 (MM6) cells were treated with 10 ng/ml phorbol 12-myristate 13-acetate (PMA). ATC code:---
Control mock treated MONO-MAC-6 cell sample
MONO-MAC-6 (MM6) cells mock treated.

breast cancer study 48 (PDX; metaplastic carcinoma, NOS; primary) / breast cancer study 48 (PDX; infiltrating duct carcinoma, NOS; primary)

Relative Expression (log2-ratio):1.8954906
Number of Samples:8 / 60
Experimental breast cancer study 48 (PDX; metaplastic carcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary metaplastic carcinoma, NOS of the breast (subcutaneously implanted).
Control breast cancer study 48 (PDX; infiltrating duct carcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary infiltrating duct carcinoma, NOS of the breast (subcutaneously implanted).

PARK2 overexpression study 1 / control transfected U251 cell sample

Relative Expression (log2-ratio):-1.8312674
Number of Samples:3 / 3
Experimental PARK2 overexpression study 1
Human brain glioma cell line U-251MG overexpressing ectopic wild-type PARK2 (parkin RBR E3 ubiquitin protein ligase). For generation of a stable cell line, the cells were infected with viral particles in the presence of 8 ug/mL polybrene followed by puromycin selection.
Control control transfected U251 cell sample
Human brain glioma cell line U-251MG with stable GFP expression. For generation of a cell line, the cells were infected with viral particles in the presence of 8 ug/mL polybrene followed by puromycin selection.

PMA study 2 (shRNA cycT1) / cycT1 depletion study 2 (shRNA)

Relative Expression (log2-ratio):1.5212469
Number of Samples:3 / 2
Experimental PMA study 2 (shRNA cycT1)
MONO-MAC-6 (MM6) cells were transduced with shRNA against cyclin T1 and then treated with 10ng/ml phorbol 12-myristate 13-acetate (PMA). ATC code:---
Control cycT1 depletion study 2 (shRNA)
MONO-MAC-6 (MM6) cells were transduced with shRNA against cyclin T1 and then mock treated.

PMA study 2 (shRNA contr.) / mock treated / transduced MONO-MAC-6 cell sample

Relative Expression (log2-ratio):1.458066
Number of Samples:3 / 2
Experimental PMA study 2 (shRNA contr.)
MONO-MAC-6 (MM6) cells were transduced with a control shRNA and then treated with 10 ng/ml phorbol 12-myristate 13-acetate (PMA). ATC code:---
Control mock treated / transduced MONO-MAC-6 cell sample
MONO-MAC-6 (MM6) cells were transduced with a control shRNA and then mock treated.

atopic dermatitis study 21 (lesional; whole skin) / normal skin tissue

Relative Expression (log2-ratio):-1.4576902
Number of Samples:5 / 6
Experimental atopic dermatitis study 21 (lesional; whole skin)
Lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal skin tissue
Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

TGF-β study 11 / untreated HCC827 cell sample

Relative Expression (log2-ratio):1.3339386
Number of Samples:3 / 3
Experimental TGF-β study 11
HCC827 cells were cultured for 3-5 weeks in the presence of 2ng/ml of TGF-β, to induce epithelial-mesenchymal transition (EMT). 24 hours prior analysis cells were re-seeded without TGF-β.
Control untreated HCC827 cell sample
HCC827 cells grown in standard media.

HIF-1a/HIF-2a depletion study 1 (normoxia; AB81) / control AB81 cell sample (normoxia)

Relative Expression (log2-ratio):-1.245431
Number of Samples:3 / 3
Experimental HIF-1a/HIF-2a depletion study 1 (normoxia; AB81)
Human podocyte cells AB81 with shRNA-mediated stable knock-down of HIF-1a and HIF-2a (Hypoxia-inducible factor 1-alpha and Hypoxia-inducible factor 2-alpha) 24 hours after treatment with normoxia (20% O2). Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates.
Control control AB81 cell sample (normoxia)
Human podocyte cell line AB81 treated with normoxia (20% O2) for 24 hours. Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates.

HIF-2a depletion study 1 (normoxia; AB81) / control AB81 cell sample (normoxia)

Relative Expression (log2-ratio):-1.1952105
Number of Samples:3 / 3
Experimental HIF-2a depletion study 1 (normoxia; AB81)
Human podocyte cells AB81 with shRNA-mediated stable knock-down of HIF-2a (Hypoxia-inducible factor 2-alpha) 24 hours after treatment with normoxia (20% O2). Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates.
Control control AB81 cell sample (normoxia)
Human podocyte cell line AB81 treated with normoxia (20% O2) for 24 hours. Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates.

adrenal gland cancer study 4 / normal adrenal cortex tissue

Relative Expression (log2-ratio):-1.1657438
Number of Samples:43 / 4
Experimental adrenal gland cancer study 4
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma (ACC).
Control normal adrenal cortex tissue
Histological normal adrenal gland cortical tissue samples derived after autopsy.