TOP TEN perturbations for 1552987_a_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1552987_a_at
Selected probe(set): 1552987_a_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1552987_a_at (1552987_a_at) across 6672 perturbations tested by GENEVESTIGATOR:

cytomegalovirus study 1 / C. albicans study 1

Relative Expression (log2-ratio):1.3787827
Number of Samples:3 / 3
Experimental cytomegalovirus study 1
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with CMV-antigens (lysate) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC´s.
Control C. albicans study 1
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with Candida albicans-antigens (sonicate) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC´s.

tetanus toxin study 1 / cytomegalovirus study 1

Relative Expression (log2-ratio):-1.3079715
Number of Samples:3 / 3
Experimental tetanus toxin study 1
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with tetanus toxoid (tetanospasmin) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC´s.
Control cytomegalovirus study 1
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with CMV-antigens (lysate) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC´s.

asthma study 30 (paucigranulocytic AIP) / control nasal scrape sample (paucigranulocytic AIP)

Relative Expression (log2-ratio):-1.0056353
Number of Samples:23 / 9
Experimental asthma study 30 (paucigranulocytic AIP)
Nasal scrape samples from asthmatic adult patients with paucigranulocytic airway inflammatory phenotype (AIP).
Control control nasal scrape sample (paucigranulocytic AIP)
Control nasal scrape samples from adult subjects with paucigranulocytic airway inflammatory phenotype (AIP).

Langerhans cell histiocytosis study 4 / normal tonsillar T-lymphocyte sample

Relative Expression (log2-ratio):-0.6877494
Number of Samples:7 / 4
Experimental Langerhans cell histiocytosis study 4
CD3+ T-lymphocyte samples isolated from peripheral blood of patients with Langerhans cell histiocytosis, prior to chemotherapy treatment. Patient with different clinical status were included in this study (unifocal, single system and multifocal, single system disease).
Control normal tonsillar T-lymphocyte sample
Normal tonsillar CD3+ T-lymphocytes were isolated from children who undergone elective tonsillectomy. The T-cells were isolated from presumably healthy tissue.

Langerhans cell histiocytosis study 3 / normal tonsillar T-lymphocyte sample

Relative Expression (log2-ratio):-0.55243397
Number of Samples:10 / 4
Experimental Langerhans cell histiocytosis study 3
CD3+ T-lymphocyte samples isolated from Langerhans cell histiocytosis (LCH) lesions in bone (8 cases) or skin (2 cases). Patient with different clinical status were included in this study (unifocal, single system; multifocal, single system and multifocal, multisystem disease).
Control normal tonsillar T-lymphocyte sample
Normal tonsillar CD3+ T-lymphocytes were isolated from children who undergone elective tonsillectomy. The T-cells were isolated from presumably healthy tissue.

necrotizing myopathy study 2 / inclusion body myositis study 2

Relative Expression (log2-ratio):0.49186754
Number of Samples:2 / 5
Experimental necrotizing myopathy study 2
Quadriceps femoris biopsy muscle samples from patients with clinical diagnosis of necrotizing myopathy (NM).
Control inclusion body myositis study 2
Quadriceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).

E. coli study 2 / unstimulated, normal monocyte-derived macrophage sample

Relative Expression (log2-ratio):0.4893899
Number of Samples:5 / 7
Experimental E. coli study 2
Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours with 2.5 × 105 heat-killed E. coli.
Control unstimulated, normal monocyte-derived macrophage sample
Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours unstimulated.

DLBCL study 7 (ABC; unclassified) / DLBCL study 7 (ABC; centrocyte-like)

Relative Expression (log2-ratio):0.46565247
Number of Samples:3 / 7
Experimental DLBCL study 7 (ABC; unclassified)
Primary tumor samples from patients with diffuse large B-cell lymphoma (activated B-cell like type). Samples were not classified based on subset-specific B-cell-associated gene signature (BAGS) and labeled as unclassified. Patients were treated according to standard protocols, and comparable doses of RCHOP- like regimens were used. No patient was treated with stem cell transplantation.
Control DLBCL study 7 (ABC; centrocyte-like)
Primary tumor samples from patients with diffuse large B-cell lymphoma (activated B-cell like type). Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS) and assigned to centrocyte-like group. Patients were treated according to standard protocols, and comparable doses of RCHOP- like regimens were used. No patient was treated with stem cell transplantation.

sarcoidosis study 6 (lacrimal gland tissue) / normal lacrimal gland tissue

Relative Expression (log2-ratio):-0.4570098
Number of Samples:12 / 7
Experimental sarcoidosis study 6 (lacrimal gland tissue)
Lacrimal gland tissue samples obtained from patients who suffered from sarcoidosis. Biopsies were formalin-fixed and paraffin-embedded.
Control normal lacrimal gland tissue
Normal lacrimal gland tissue samples. The control tissue was obtained during surgery on eyes with non-inflamed orbits, such as blepharoplasties and enucleations. Biopsies were formalin-fixed and paraffin-embedded.

LPS study 4 / mock treated MONO-MAC-6 cell sample

Relative Expression (log2-ratio):0.45246315
Number of Samples:2 / 2
Experimental LPS study 4
MONO-MAC-6 (MM6) cells were treated with 10 ng/ml lipopolysaccharide (LPS). ATC code:---
Control mock treated MONO-MAC-6 cell sample
MONO-MAC-6 (MM6) cells mock treated.