TOP TEN perturbations for 1553031_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1553031_at
Selected probe(set): 237690_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1553031_at (237690_at) across 6673 perturbations tested by GENEVESTIGATOR:
Langerhans cell histiocytosis study 2 (multifocal) / normal epidermal Langerhans cell sample
Relative Expression (log2-ratio):-4.9858294Number of Samples:2 / 10
Experimental | Langerhans cell histiocytosis study 2 (multifocal) |
Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with multifocal (bone, skin lesions) disease. | |
Control | normal epidermal Langerhans cell sample |
Normal epidermal Langerhans cells (CD207+) were isolated from skin of children donors (age < 18 years). The Langerhans cells were isolated from presumably healthy tissue. |
Langerhans cell histiocytosis study 2 (multisystem) / normal epidermal Langerhans cell sample
Relative Expression (log2-ratio):-4.8962526Number of Samples:2 / 10
Experimental | Langerhans cell histiocytosis study 2 (multisystem) |
Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with multifocal, multisystem (disseminated) disease. Both patients received chemotherapy. Sites of LCH lesions: subj.ID:1 (skin, lungs, multiple skull, mastoid, gingiva), subj.ID:13 (mandible, skull, vertebrae, recurrent orbit, liver, spleen, pituitary gland). | |
Control | normal epidermal Langerhans cell sample |
Normal epidermal Langerhans cells (CD207+) were isolated from skin of children donors (age < 18 years). The Langerhans cells were isolated from presumably healthy tissue. |
Langerhans cell histiocytosis study 2 (unifocal) / normal epidermal Langerhans cell sample
Relative Expression (log2-ratio):-4.8627415Number of Samples:8 / 10
Experimental | Langerhans cell histiocytosis study 2 (unifocal) |
Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with unifocal, single system disease (bone lesion). | |
Control | normal epidermal Langerhans cell sample |
Normal epidermal Langerhans cells (CD207+) were isolated from skin of children donors (age < 18 years). The Langerhans cells were isolated from presumably healthy tissue. |
melanoma study 34 (metastatic) / melanoma study 34 (in situ)
Relative Expression (log2-ratio):-4.8506966Number of Samples:40 / 2
Experimental | melanoma study 34 (metastatic) |
Metastatic tumor tissue sample obtained from the patients with metastatic malignant melanoma of the skin. Metastatic samples composed of 22 macroscopic lymph node metastases, 16 subcutaneous metastases and 2 solid organ metastases (adrenal and brain). | |
Control | melanoma study 34 (in situ) |
Tumor tissue from the skin of patients with melanoma in situ. |
ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary) / ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary)
Relative Expression (log2-ratio):-4.535445Number of Samples:2 / 2
Experimental | ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary transitional cell carcinoma, NOS of the ovary (subcutaneously implanted). | |
Control | ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary mixed tumor, malignant, NOS of the ovary (subcutaneously implanted). |
AsPC-1 / BxPC-3
Relative Expression (log2-ratio):-4.505126Number of Samples:3 / 3
Experimental | AsPC-1 |
Human xenograft derived metastatic cancer cell line derived from mouse xenografts initiated with metastatic cells from the ascites derived from a 62 years old female Caucasian patient with pancreatic adenocarcinoma. Synonyms:AsPc-1; Aspc-1; ASPC-1; As-PC1; ASPC1; AsPC1; Aspc1; AsPc1 Cellosaurus code: | |
Control | BxPC-3 |
Human pancreatic adenocarcinoma cell line derived from a 61 years old female patient. Synonyms:BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3 Cellosaurus code: |
melanoma study 34 (metastatic) / normal skin tissue
Relative Expression (log2-ratio):-4.3211174Number of Samples:40 / 4
Experimental | melanoma study 34 (metastatic) |
Metastatic tumor tissue sample obtained from the patients with metastatic malignant melanoma of the skin. Metastatic samples composed of 22 macroscopic lymph node metastases, 16 subcutaneous metastases and 2 solid organ metastases (adrenal and brain). | |
Control | normal skin tissue |
Normal skin tissue. |
ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; primary) / ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary)
Relative Expression (log2-ratio):-4.1844683Number of Samples:13 / 2
Experimental | ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary serous cystadenocarcinoma, NOS of the ovary (subcutaneously implanted). | |
Control | ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary mixed tumor, malignant, NOS of the ovary (subcutaneously implanted). |
melanoma study 34 (primary) / melanoma study 34 (in situ)
Relative Expression (log2-ratio):-3.838296Number of Samples:14 / 2
Experimental | melanoma study 34 (primary) |
Primary tumor tissue from the skin of patients with primary cutaneous melanoma (PCM). PCM consisted of 2 thin melanomas (< 1 mm; T1), 3 intermediate-thickness melanomas (1–4 mm; T2-3), and 9 thick melanomas (> 4 mm; T4). | |
Control | melanoma study 34 (in situ) |
Tumor tissue from the skin of patients with melanoma in situ. |
atopic dermatitis study 21 (lesional; epidermis) / normal epidermis tissue
Relative Expression (log2-ratio):-3.8299885Number of Samples:5 / 10
Experimental | atopic dermatitis study 21 (lesional; epidermis) |
Lesional epidermal samples isolated from patient with moderate-to-severe chronic atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %. | |
Control | normal epidermis tissue |
Epidermal samples isolated from healthy subjects by laser capture microdissection. |