TOP TEN perturbations for 1553052_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1553052_at
Selected probe(set): 1553052_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1553052_at (1553052_at) across 6593 perturbations tested by GENEVESTIGATOR:
glioma study 17 (astrocytoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)
Relative Expression (log2-ratio):-0.7429471Number of Samples:3 / 3
Experimental | glioma study 17 (astrocytoma; A2B5+) |
Oligodendrocyte progenitor cells (OPC) isolated from low grade astrocytoma (grade II). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 36 ± 7 years old. | |
Control | non-tumor oligodendrocyte progenitor cell sample (cortex) |
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. |
nimesulide study 5 (330uM) / vehicle (DMSO) treated hepatocyte sample
Relative Expression (log2-ratio):0.6552696Number of Samples:2 / 2
Experimental | nimesulide study 5 (330uM) |
Hepatocytes treated with compound: nimesulide (330uM; CHEMBL56367) for 24 hours. ATC code:, | |
Control | vehicle (DMSO) treated hepatocyte sample |
Hepatocytes treated with vehicle (DMSO) for 24 hours. |
tunicamycin study 2 (2ug/ml; HCT 116) / untreated HCT 116 cell sample
Relative Expression (log2-ratio):-0.65064573Number of Samples:3 / 3
Experimental | tunicamycin study 2 (2ug/ml; HCT 116) |
Human colon carcinoma cell line HCT116 was treated with 2 ug/ml tunicamycin for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:--- | |
Control | untreated HCT 116 cell sample |
Human colon carcinoma cell line HCT116 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS. |
inclusion body myositis study 2 / normal quadriceps tissue
Relative Expression (log2-ratio):-0.62533665Number of Samples:5 / 2
Experimental | inclusion body myositis study 2 |
Quadriceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM). | |
Control | normal quadriceps tissue |
Quadriceps femoris biopsy muscle samples from control subjects. |
glioma study 17 (glioblastoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)
Relative Expression (log2-ratio):-0.6151166Number of Samples:3 / 3
Experimental | glioma study 17 (glioblastoma; A2B5+) |
Oligodendrocyte progenitor cells (OPC) isolated from high grade glioblastoma (grade IV). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 66 ± 5 years old males. | |
Control | non-tumor oligodendrocyte progenitor cell sample (cortex) |
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. |
brefeldin A study 1 (0.5ug/ml; HCT 116) / untreated HCT 116 cell sample
Relative Expression (log2-ratio):-0.61165285Number of Samples:3 / 3
Experimental | brefeldin A study 1 (0.5ug/ml; HCT 116) |
Human colon carcinoma cell line HCT116 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:--- | |
Control | untreated HCT 116 cell sample |
Human colon carcinoma cell line HCT116 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS. |
renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue
Relative Expression (log2-ratio):0.58391285Number of Samples:4 / 2
Experimental | renal cell carcinoma study 6 (chromophobe type) |
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC). | |
Control | normal kidney tissue |
Normal fetal kidney tissue samples. |
tunicamycin study 2 (2ug/ml; HCT 116 DICER1(-/-)) / untreated HCT 116 DICER1(-/-) cell sample
Relative Expression (log2-ratio):-0.5584507Number of Samples:3 / 3
Experimental | tunicamycin study 2 (2ug/ml; HCT 116 DICER1(-/-)) |
Derived human colon carcinoma cell line HCT 116 DICER1(-/-) with knockout DICER gene in exon 5 was treated with 2 ug/ml tunicamycin for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:--- | |
Control | untreated HCT 116 DICER1(-/-) cell sample |
Derived human colon carcinoma cell line HCT 116 DICER1(-/-) with knockout DICER gene in exon 5 by was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS. |
oxyphilic adenoma study 1 / normal kidney tissue
Relative Expression (log2-ratio):0.55370235Number of Samples:4 / 2
Experimental | oxyphilic adenoma study 1 |
Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma). | |
Control | normal kidney tissue |
Normal fetal kidney tissue samples. |
ovarian tumor study 13 / ovarian tumor study 12
Relative Expression (log2-ratio):0.5340185Number of Samples:18 / 6
Experimental | ovarian tumor study 13 |
Human epithelial tumor cell samples from the ovary of patients with serous adenocarcinoma. Samples were derived by laser capture microdissection (LCM). | |
Control | ovarian tumor study 12 |
Human stromal tumor cell samples from the ovary of patients with serous adenocarcinoma. Samples were derived by laser capture microdissection (LCM). |