TOP TEN perturbations for 1553074_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1553074_at
Selected probe(set): 1553074_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1553074_at (1553074_at) across 6673 perturbations tested by GENEVESTIGATOR:
myotonic dystrophy study 4 (skeletal muscle; DM2) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):3.2360191Number of Samples:8 / 3
Experimental | myotonic dystrophy study 4 (skeletal muscle; DM2) |
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (biceps brachii; DM2) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):2.9714432Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (biceps brachii; DM2) |
Biceps brachii biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (deltoid muscle; DM1) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):2.8667154Number of Samples:2 / 3
Experimental | myotonic dystrophy study 4 (deltoid muscle; DM1) |
Deltoid muscle biopsies obtained from patients with myotonic dystrophy type 1 (DM1). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (biceps brachii; DM-like) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):2.8051538Number of Samples:9 / 3
Experimental | myotonic dystrophy study 4 (biceps brachii; DM-like) |
Biceps brachii biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (deltoid muscle; DM-like) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):2.7799654Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (deltoid muscle; DM-like) |
Deltoid muscle biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
Duchenne muscular dystrophy study 5 (severe) / normal vastus lateralis tissue
Relative Expression (log2-ratio):-2.7703915Number of Samples:13 / 6
Experimental | Duchenne muscular dystrophy study 5 (severe) |
Biopsies of vastus lateralis muscle from male patients with Duchenne muscular dystrophy and severe fibrotic replacement. All subjects showed evidence of a dystrophic process (degeneration/regeneration of muscle fibers) and absence of dystrophin. | |
Control | normal vastus lateralis tissue |
Biopsies of vastus lateralis muscle from young adult volunteers. Samples were taken as normal controls from baseline samples of exercise experiments. |
myotonic dystrophy study 4 (deltoid muscle; DM2) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):2.7131329Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (deltoid muscle; DM2) |
Deltoid muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
Duchenne muscular dystrophy study 4 / normal skeletal muscle tissue
Relative Expression (log2-ratio):-2.657609Number of Samples:16 / 6
Experimental | Duchenne muscular dystrophy study 4 |
Skeletal muscle biopsies obtained from boys with Duchenne muscular dystrophy. | |
Control | normal skeletal muscle tissue |
Histologically normal skeletal muscle biopsies. |
Duchenne muscular dystrophy study 5 (moderate) / normal vastus lateralis tissue
Relative Expression (log2-ratio):-2.6571589Number of Samples:4 / 6
Experimental | Duchenne muscular dystrophy study 5 (moderate) |
Biopsies of vastus lateralis muscle from male patients with Duchenne muscular dystrophy and moderate fibrotic replacement. All subjects showed evidence of a dystrophic process (degeneration/regeneration of muscle fibers) and absence of dystrophin. | |
Control | normal vastus lateralis tissue |
Biopsies of vastus lateralis muscle from young adult volunteers. Samples were taken as normal controls from baseline samples of exercise experiments. |
dysferlinopathy study 2 (LGMD2B; severe) / normal vastus lateralis tissue
Relative Expression (log2-ratio):-2.5651312Number of Samples:2 / 6
Experimental | dysferlinopathy study 2 (LGMD2B; severe) |
Biopsies of vastus lateralis muscle from male patients with limb-girdle muscular dystrophy 2B (LGMD2B) and severe fibrotic replacement. All subjects showed evidence of a dystrophic process (degeneration/regeneration of muscle fibers) and dysferlin mutation. | |
Control | normal vastus lateralis tissue |
Biopsies of vastus lateralis muscle from young adult volunteers. Samples were taken as normal controls from baseline samples of exercise experiments. |