TOP TEN perturbations for 1553080_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553080_at
Selected probe(set): 1553080_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553080_at (1553080_at) across 6540 perturbations tested by GENEVESTIGATOR:

breast cancer study 11 / normal breast tissue

Relative Expression (log2-ratio):-2.7128124
Number of Samples:351 / 4
Experimental breast cancer study 11
Tissue samples from female patients with primary invasive breast cancer after surgery .
Control normal breast tissue
Tissue samples of the breast from healthy female individuals after breast reduction mammoplasty.

systemic lupus erythematosus study 13 (untreated) / normal PBMC sample

Relative Expression (log2-ratio):-1.0016708
Number of Samples:4 / 5
Experimental systemic lupus erythematosus study 13 (untreated)
Peripheral blood mononuclear cells (PBMCs) obtained from systemic lupus erythematosus (SLE) patients. Freshly isolated PBMCs were cultured in RPMI/10% FBS for 6 hours. Lupus patients fulfilled American College of Rheumatology classification criteria for disease, and disease activity was quantified by SLEDAI. Patients were excluded if they showed symptoms of recent or active infection or were pregnant. None of the patients was taking Pioglitazone or other PPAR-γ agonists.
Control normal PBMC sample
Peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects. Freshly isolated PBMCs were cultured in RPMI/10% FBS for 6 hours.

hepatitis C study 5 (under treatment; non-responder) / hepatitis C study 5 (under treatment; responder)

Relative Expression (log2-ratio):0.87545776
Number of Samples:6 / 6
Experimental hepatitis C study 5 (under treatment; non-responder)
Microdissected hepatocyte samples obtained after liver tissue biopsy from chronic hepatitis C (CH-C) patients after treatment with interferon-alpha 2b (IFN-a 2b) and ribavirin (Rib) in combination. Patients received IFN-a 2b (6 MU , every day for 2 weeks, then three times a week for 22 weeks) and Ribavirin (10–13 mg/kg/day) combination therapy for 24 weeks. Individuals had no treatment success and were for that non-responders after HCV viremia detected at the cessation of therapy.
Control hepatitis C study 5 (under treatment; responder)
Microdissected hepatocyte samples obtained after liver tissue biopsy from chronic hepatitis C (CH-C) patients after treatment with interferon-alpha 2b (IFN-a 2b) and ribavirin (Rib) in combination. Patients received IFN-a 2b (6 MU, every day for 2 weeks, then three times a week for 22 weeks) and Ribavirin (10–13 mg/kg/day) combination therapy for 24 weeks. Individuals had treatment success and were for that responders after no HCV viremia detected at the cessation of therapy. Patients had a sustained virologic response (SVR; clearance of HCV viremia at 24 weeks after cessation of therapy).

atopic dermatitis study 21 (non-lesional; whole skin) / normal skin tissue

Relative Expression (log2-ratio):-0.8280778
Number of Samples:5 / 6
Experimental atopic dermatitis study 21 (non-lesional; whole skin)
Non-lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal skin tissue
Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

Sjogren's syndrome study 2 (pSS) / normal parotid gland tissue

Relative Expression (log2-ratio):-0.77721214
Number of Samples:7 / 9
Experimental Sjogren's syndrome study 2 (pSS)
Incisional biopsy of one parotid gland of patients who fulfilled the 2002 AECG criteria for primary Sjogren's syndrome (pSS). Patients were at least 21 years old.
Control normal parotid gland tissue
Samples taken from the dorsal caudal lobe of the parotid gland from control subjects that were at least 21 years old. Samples were harvested during surgery for oral or oropharyngeal squamous cell carcinoma. Histopathologic evaluation of parotid tissue from controls revealed no carcinoma

atopic dermatitis study 21 (lesional; whole skin) / normal skin tissue

Relative Expression (log2-ratio):-0.7649064
Number of Samples:5 / 6
Experimental atopic dermatitis study 21 (lesional; whole skin)
Lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal skin tissue
Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

Sjogren's syndrome study 2 (non-pSS) / normal parotid gland tissue

Relative Expression (log2-ratio):-0.6813965
Number of Samples:14 / 9
Experimental Sjogren's syndrome study 2 (non-pSS)
Incisional biopsy of one parotid gland of patients with Sicca-syndrome who did not fulfill the 2002 AECG criteria for primary Sjogren's syndrome (non-pSS Sicca). Patients were at least 21 years old.
Control normal parotid gland tissue
Samples taken from the dorsal caudal lobe of the parotid gland from control subjects that were at least 21 years old. Samples were harvested during surgery for oral or oropharyngeal squamous cell carcinoma. Histopathologic evaluation of parotid tissue from controls revealed no carcinoma

brefeldin A study 1 (0.5ug/ml; HCT 116) / untreated HCT 116 cell sample

Relative Expression (log2-ratio):-0.6806655
Number of Samples:3 / 3
Experimental brefeldin A study 1 (0.5ug/ml; HCT 116)
Human colon carcinoma cell line HCT116 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:---
Control untreated HCT 116 cell sample
Human colon carcinoma cell line HCT116 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS.

pioglitazone study 4 (1uM; 6h) / normal PBMC sample

Relative Expression (log2-ratio):-0.6587825
Number of Samples:5 / 5
Experimental pioglitazone study 4 (1uM; 6h)
Peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects and cultured with pioglitazone. Freshly isolated PBMCs were cultured in RPMI/10% FBS in the presence of 1uM pioglitazone for 6 hours. ATC code:
Control normal PBMC sample
Peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects. Freshly isolated PBMCs were cultured in RPMI/10% FBS for 6 hours.

systemic lupus erythematosus study 3 / normal blood sample

Relative Expression (log2-ratio):0.6182904
Number of Samples:89 / 30
Experimental systemic lupus erythematosus study 3
Blood samples derived from patients with anti-ribonuclear protein-positive (anti-RNP+) systemic lupus erythematosus (SLE).
Control normal blood sample
Blood samples from healthy individuals.