TOP TEN perturbations for 1553150_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553150_at
Selected probe(set): 227021_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553150_at (227021_at) across 6672 perturbations tested by GENEVESTIGATOR:

IL-4; GM-CSF study 1 (early) / untreated monocyte sample

Relative Expression (log2-ratio):-3.0159626
Number of Samples:6 / 12
Experimental IL-4; GM-CSF study 1 (early)
Monocytes, cultured with vehicle (DMSO/ethanol) and 500 U/ml IL-4 and 800 U/ml GM-CSF for 6 hours.
Control untreated monocyte sample
Freshly isolated human monocytes from healthy donors.

zalypsis study 2 / untreated OPM1 cell sample

Relative Expression (log2-ratio):-2.9917564
Number of Samples:2 / 2
Experimental zalypsis study 2
OPM1 multiple myeloma cells treated in vitro with zalypsis (5 nM), a novel marine-derived compound with potent antimyeloma activity. Cells were harvested at the beginning of induction of cell death (15-20% cell death as assessed by Annexin V-FITC staining). ATC code:---
Control untreated OPM1 cell sample
OPM1 multiple myeloma cells untreated.

precursor-B-ALL study 2 (E2A-PBX1) / T-ALL study 2

Relative Expression (log2-ratio):2.8882475
Number of Samples:2 / 13
Experimental precursor-B-ALL study 2 (E2A-PBX1)
Peripheral blood and bone marrow samples of pediatric patients with precursor B-ALL [t(1;19)(q23;p13.3)/E2A PBX1 (TCF3 PBX1)]. Patients were part of the Dutch Childhood Oncology Group (DCOG).
Control T-ALL study 2
Peripheral blood or bone marrow samples of pediatric patients with childhood T-ALL. Patients were part of the Dutch Childhood Oncology Group (DCOG).

rheumatoid arthritis study 31 / TNF-ɑ study 20

Relative Expression (log2-ratio):2.810771
Number of Samples:4 / 3
Experimental rheumatoid arthritis study 31
Monocyte samples isolated from patients with rheumatoid arthritis (RA). Monocytes from whole blood were depleted from granulocytes by CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. Patients fulfilled the revised American College of Rheumatology criteria (ACR) for RA.
Control TNF-ɑ study 20
Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml TNFα in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling.

colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; liver)

Relative Expression (log2-ratio):-2.6193485
Number of Samples:2 / 25
Experimental colorectal cancer study 43 (metastase; brain)
Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma.
Control colorectal cancer study 43 (metastase; liver)
Metastatic tumor tissue obtained from the liver of patients with primary colon adenocarcinoma.

influenza virus study 11 (A/H5N3) / influenza virus study 4 (A/H1N1)

Relative Expression (log2-ratio):2.5858936
Number of Samples:3 / 3
Experimental influenza virus study 11 (A/H5N3)
Human carcinoma cell line A549 infected with influenza A virus subtype influenza virus A/duck/Malaysia/F119/3/1997(H5N3). Samples were taken 10 hours post-infection.
Control influenza virus study 4 (A/H1N1)
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection.

expO breast cancer study 1 (intraductal carcinoma; in situ) / expO breast cancer study 1 (inflammatory carcinoma; primary)

Relative Expression (log2-ratio):2.4725752
Number of Samples:3 / 2
Experimental expO breast cancer study 1 (intraductal carcinoma; in situ)
Tumor tissue samples obtained from the breast of patients with intraductal carcinoma.
Control expO breast cancer study 1 (inflammatory carcinoma; primary)
Primary tumor tissue samples obtained from the breast of patients with inflammatory carcinoma.

expO breast cancer study 1 (intraductal carcinoma; in situ) / expO breast cancer study 1 (cribriform carcinoma; primary)

Relative Expression (log2-ratio):2.4361906
Number of Samples:3 / 2
Experimental expO breast cancer study 1 (intraductal carcinoma; in situ)
Tumor tissue samples obtained from the breast of patients with intraductal carcinoma.
Control expO breast cancer study 1 (cribriform carcinoma; primary)
Primary tumor tissue samples obtained from the breast of patients with cribriform carcinoma.

expO breast cancer study 1 (intraductal carcinoma; in situ) / expO breast cancer study 1 (ductal and lobular carcinoma; primary)

Relative Expression (log2-ratio):2.327649
Number of Samples:3 / 4
Experimental expO breast cancer study 1 (intraductal carcinoma; in situ)
Tumor tissue samples obtained from the breast of patients with intraductal carcinoma.
Control expO breast cancer study 1 (ductal and lobular carcinoma; primary)
Primary tumor tissue samples obtained from the breast of patients with ductal and lobular carcinoma.

RAF1 depletion study 2 / mock transfected SW-620 cell sample

Relative Expression (log2-ratio):-2.3182878
Number of Samples:6 / 6
Experimental RAF1 depletion study 2
RNAi-mediated gene knockdown of RAF1 in colorectal cancer cell line SW-620.
Control mock transfected SW-620 cell sample
SW-620 colorectal cell line sample transduced with non-targeting pLKO_NonTarget vector.