TOP TEN perturbations for 1553157_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553157_at
Selected probe(set): 232781_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553157_at (232781_at) across 6672 perturbations tested by GENEVESTIGATOR:

medulloblastoma study 1 / non-tumor brain tissue

Relative Expression (log2-ratio):4.3106337
Number of Samples:17 / 9
Experimental medulloblastoma study 1
Primary tumor tissue sample from the infratentorial brain of pediatric patients with classical medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

brain tumor study 1 (medulloblastoma) / normal brain tissue

Relative Expression (log2-ratio):4.026593
Number of Samples:22 / 12
Experimental brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

brain tumor study 1 (medulloblastoma) / brain tumor study 1 (ependymoma)

Relative Expression (log2-ratio):3.9450417
Number of Samples:22 / 46
Experimental brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.
Control brain tumor study 1 (ependymoma)
Primary tumor tissue sample from the brain of patients with ependymoma.

atypical teratoid/rhabdoid tumor study 1 / medulloblastoma study 1

Relative Expression (log2-ratio):-3.8990326
Number of Samples:20 / 17
Experimental atypical teratoid/rhabdoid tumor study 1
Primary tumor tissue sample from the brain of pediatric patients with atypical teratoid/rhabdoid tumor (AT/RT).
Control medulloblastoma study 1
Primary tumor tissue sample from the infratentorial brain of pediatric patients with classical medulloblastoma.

brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (medulloblastoma)

Relative Expression (log2-ratio):-3.8773184
Number of Samples:15 / 22
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.

brain tumor study 1 (medulloblastoma) / brain tumor study 1 (glioblastoma)

Relative Expression (log2-ratio):3.78368
Number of Samples:22 / 34
Experimental brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.
Control brain tumor study 1 (glioblastoma)
Primary tumor tissue sample from the brain of patients with glioblastoma multiformae.

acute respiratory distress syndrome study 1 / normal blood neutrophil sample

Relative Expression (log2-ratio):3.412921
Number of Samples:12 / 12
Experimental acute respiratory distress syndrome study 1
Primary neutrophils isolated from blood samples of patients fulfilling the Berlin criteria of acute respiratory distress syndrome (ARDS). Neutrophils were purified over discontinuous plasma-percoll gradients. Patients were representative of the full patients cohort in terms of age, gender, ARDS severity and causation.
Control normal blood neutrophil sample
Primary neutrophils isolated from blood samples of healthy volunteers purified over discontinuous plasma-percoll gradients.

ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; metastatic) / ovarian tumor study 30 (PDX; carcinoma, NOS; metastatic)

Relative Expression (log2-ratio):-2.7544794
Number of Samples:8 / 2
Experimental ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; metastatic)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary serous cystadenocarcinoma, NOS of the ovary (subcutaneously implanted). Metastatic site of patient tumor sample is not reported.
Control ovarian tumor study 30 (PDX; carcinoma, NOS; metastatic)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary carcinoma, NOS of the ovary (subcutaneously implanted). Metastatic site of patient tumor sample is not reported.

HIF-1a/HIF-2a depletion study 1 (hypoxia; HK2) / HIF-1a/HIF-2a depletion study 1 (normoxia; AB81)

Relative Expression (log2-ratio):2.602273
Number of Samples:3 / 3
Experimental HIF-1a/HIF-2a depletion study 1 (hypoxia; HK2)
Proximal tubule epithelial cell line HK-2 with shRNA-mediated stable knock-down of HIF-1a and HIF-2a (Hypoxia-inducible factor 1-alpha and Hypoxia-inducible factor 2-alpha) 24 hours after treatment with hypoxia (20% O2). HK-2 cells were cultured in DMEM/F-12 supplemented with 10% fetal calf serum (FCS), 1% ITS, hydrocortisone, and antibiotics. The cells were incubated at 37 °C.
Control HIF-1a/HIF-2a depletion study 1 (normoxia; AB81)
Human podocyte cells AB81 with shRNA-mediated stable knock-down of HIF-1a and HIF-2a (Hypoxia-inducible factor 1-alpha and Hypoxia-inducible factor 2-alpha) 24 hours after treatment with normoxia (20% O2). Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates.

medulloblastoma study 2 / non-tumor brain tissue

Relative Expression (log2-ratio):2.492302
Number of Samples:4 / 9
Experimental medulloblastoma study 2
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.