TOP TEN perturbations for 1553277_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1553277_at
Selected probe(set): 227072_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1553277_at (227072_at) across 6673 perturbations tested by GENEVESTIGATOR:
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; metastatic) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic)
Relative Expression (log2-ratio):-4.0696926Number of Samples:2 / 2
| Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, leiomyosarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
| Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, clear cell sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. |
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; metastatic) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic)
Relative Expression (log2-ratio):-3.8616695Number of Samples:3 / 2
| Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
| Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, clear cell sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. |
basal cell carcinoma study 3 / normal epidermal keratinocytes
Relative Expression (log2-ratio):-3.7050161Number of Samples:4 / 2
| Experimental | basal cell carcinoma study 3 |
| Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC). | |
| Control | normal epidermal keratinocytes |
| Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37°C in humidified air containing 5% CO2. |
engineered skin substitute study 2 (late) / engineered skin substitute study 1 (late)
Relative Expression (log2-ratio):-2.739379Number of Samples:5 / 3
| Experimental | engineered skin substitute study 2 (late) |
| Human skin substitutes tissue samples collected after 42 and 56 days after transplantation to athymic mice. | |
| Control | engineered skin substitute study 1 (late) |
| Human skin substitutes tissue samples collected after 14 days in culture. |
Edwards syndrome study 1 (trisomy18) / prenatal chorion villus cell sample
Relative Expression (log2-ratio):2.3558197Number of Samples:3 / 6
| Experimental | Edwards syndrome study 1 (trisomy18) |
| Prenatal chorion villus cells, trisomy 18. | |
| Control | prenatal chorion villus cell sample |
| Prenatal chorion villus cells, normal karyotype. |
stem cell differentiation study 59 (iDRG; 15d) / stem cell differentiation study 59 (8d)
Relative Expression (log2-ratio):-2.324421Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 15d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper. | |
| Control | stem cell differentiation study 59 (8d) |
| WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper. |
zalypsis study 2 / untreated OPM1 cell sample
Relative Expression (log2-ratio):-2.2781525Number of Samples:2 / 2
| Experimental | zalypsis study 2 |
| OPM1 multiple myeloma cells treated in vitro with zalypsis (5 nM), a novel marine-derived compound with potent antimyeloma activity. Cells were harvested at the beginning of induction of cell death (15-20% cell death as assessed by Annexin V-FITC staining). ATC code:--- | |
| Control | untreated OPM1 cell sample |
| OPM1 multiple myeloma cells untreated. |
C. difficile study 1 (TcdA; 24h) / untreated HCT 8 cell sample
Relative Expression (log2-ratio):-2.2755613Number of Samples:2 / 2
| Experimental | C. difficile study 1 (TcdA; 24h) |
| HCT 8 cells were treated with 100 ng/ml Toxin A (TcdA) isolated from Clostridium difficile strain VPI-10643 in RPMI-1640 supplemented with 10% heat-inactivated fetal bovine serum and 1mM sodium pyruvate for 24 hours. | |
| Control | untreated HCT 8 cell sample |
| Untreated HCT 8 cell sample cultured in RPMI-1640 supplemented with 10% heat-inactivated fetal bovine serum and 1mM sodium pyruvate for 24 hours. |
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; primary) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, liposarcoma, well differentiated type; primary)
Relative Expression (log2-ratio):2.2588263Number of Samples:7 / 2
| Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; primary) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, sarcoma, NOS of the soft tissue (subcutaneously implanted). | |
| Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, liposarcoma, well differentiated type; primary) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, liposarcoma, well differentiated type of the soft tissue (subcutaneously implanted). |
engineered skin substitute study 2 (late) / engineered skin substitute study 2 (early)
Relative Expression (log2-ratio):-2.2509832Number of Samples:5 / 6
| Experimental | engineered skin substitute study 2 (late) |
| Human skin substitutes tissue samples collected after 42 and 56 days after transplantation to athymic mice. | |
| Control | engineered skin substitute study 2 (early) |
| Human skin substitutes tissue samples collected after 3 and 7 days after transplantation to athymic mice. |