TOP TEN perturbations for 1553322_s_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1553322_s_at
Selected probe(set): 224955_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1553322_s_at (224955_at) across 6673 perturbations tested by GENEVESTIGATOR:
zalypsis study 2 / untreated OPM1 cell sample
Relative Expression (log2-ratio):-3.9233541Number of Samples:2 / 2
Experimental | zalypsis study 2 |
OPM1 multiple myeloma cells treated in vitro with zalypsis (5 nM), a novel marine-derived compound with potent antimyeloma activity. Cells were harvested at the beginning of induction of cell death (15-20% cell death as assessed by Annexin V-FITC staining). ATC code:--- | |
Control | untreated OPM1 cell sample |
OPM1 multiple myeloma cells untreated. |
zalypsis study 1 / untreated MM1S cell sample
Relative Expression (log2-ratio):-3.8457022Number of Samples:2 / 2
Experimental | zalypsis study 1 |
MM1S multiple myeloma cells treated in vitro with zalypsis (5 nM), a novel marine-derived compound with potent antimyeloma activity. Cells were harvested at the beginning of induction of cell death (15-20% cell death as assessed by Annexin V-FITC staining). ATC code:--- | |
Control | untreated MM1S cell sample |
MM1S multiple myeloma cells untreated. |
breast cancer study 24 / breast cancer study 22
Relative Expression (log2-ratio):2.9963818Number of Samples:10 / 10
Experimental | breast cancer study 24 |
Freshly purified CD4+ tumor-infiltrating T cells derived from female primary invasive breast ductal carcinoma. For individual patient characteristics see detailed sample information. The initial tissue dissociation was performed mechanically, without enzymatic digestion. | |
Control | breast cancer study 22 |
Freshly purified CD4+ T cells from peripheral blood of female donors with primary invasive breast ductal carcinoma. For individual patient characteristics see detailed sample information. |
oncolytic herpes simplex virus study 2 / mock infected peripheral nerve sheath tumor (S462) cell sample
Relative Expression (log2-ratio):-2.8963213Number of Samples:3 / 3
Experimental | oncolytic herpes simplex virus study 2 |
Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours. | |
Control | mock infected peripheral nerve sheath tumor (S462) cell sample |
Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours. |
bone cancer study 1 (PDX; osteosarcoma, NOS; primary) / bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)
Relative Expression (log2-ratio):-2.8026981Number of Samples:2 / 2
Experimental | bone cancer study 1 (PDX; osteosarcoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary osteosarcoma, NOS of the bone (subcutaneously implanted). | |
Control | bone cancer study 1 (PDX; myxoid chondrosarcoma; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary myxoid chondrosarcoma of the bone (subcutaneously implanted). |
Roberts syndrome study 1 / Cornelia de Lange syndrome study 1
Relative Expression (log2-ratio):2.769229Number of Samples:2 / 17
Experimental | Roberts syndrome study 1 |
Lymphoblastoid cell line samples from probands with Roberts syndrome (RBS). | |
Control | Cornelia de Lange syndrome study 1 |
Lymphoblastoid cell line samples from severely affected Cornelia de Lange syndrome (CdLS) probands with NIPBL isoform B protein-truncating mutations. |
PMA; ionomycine study 2 / unstimulated CD4 memory T-cell sample
Relative Expression (log2-ratio):2.768839Number of Samples:8 / 8
Experimental | PMA; ionomycine study 2 |
CD4+ memory T cells derived from peripheral blood of healthy subjects were stimulated for 3 hours with phorbol 12-myristate 13-acetate (PMA, 10 ng/ml) and ionomycin (1 µg/ml). ATC code:--- | |
Control | unstimulated CD4 memory T-cell sample |
Unstimulated CD4+ memory T cells derived from peripheral blood of healthy subjects. |
stem cell differentiation study 50 (MYB shRNA; ASC; proerythroblast) / stem cell differentiation study 50 (mock shRNA; ASC; proerythroblast)
Relative Expression (log2-ratio):-2.6784496Number of Samples:4 / 4
Experimental | stem cell differentiation study 50 (MYB shRNA; ASC; proerythroblast) |
Proerythroblast differentiated from MYB shRNA transduced hematopoietic stem/progenitor cells (CD34+). CD34+ hematopoietic stem/progenitor cells (HSC) were transduced with lentivirus expressing shRNA targeting MYB gene with following differentiation to the erythroid lineage. HSCs were obtained from magnetically sorted G-CSF mobilized peripheral blood mononuclear cells of healthy donors. Cells were expanded in StemSpan SFEM medium supplied with Flt-3 ligand (100 ng/ml), SCF (100 ng/ml), IL-3 (20 ng/ml), IL-6 (20 ng/ml) and penicillin/streptomycin. Cells were harvested for total RNA extraction at the proerythroblast stage of differentiation. | |
Control | stem cell differentiation study 50 (mock shRNA; ASC; proerythroblast) |
Proerythroblast differentiated from control shRNA transduced hematopoietic stem/progenitor cells (CD34+). CD34+ hematopoietic stem/progenitor cells (HSC) were transduced with lentivirus expressing control shRNA with following differentiation to the erythroid lineage. HSCs were obtained from magnetically sorted G-CSF mobilized peripheral blood mononuclear cells of healthy donors. Cells were expanded in StemSpan SFEM medium supplied with Flt-3 ligand (100 ng/ml), SCF (100 ng/ml), IL-3 (20 ng/ml), IL-6 (20 ng/ml) and penicillin/streptomycin. Cells were harvested for total RNA extraction at the proerythroblast stage of differentiation. |
breast cancer study 42 (metastase; lymph node) / breast cancer study 42 (metastase; chest wall)
Relative Expression (log2-ratio):-2.5822868Number of Samples:7 / 2
Experimental | breast cancer study 42 (metastase; lymph node) |
Metastatic tumor tissue obtained from the lymph node of patients with primary breast adenocarcinoma. | |
Control | breast cancer study 42 (metastase; chest wall) |
Metastatic tumor tissue obtained from the chest wall of patients with primary breast adenocarcinoma. |
Roberts syndrome study 1 / normal lymphoblastoid cell line sample
Relative Expression (log2-ratio):2.5594969Number of Samples:2 / 18
Experimental | Roberts syndrome study 1 |
Lymphoblastoid cell line samples from probands with Roberts syndrome (RBS). | |
Control | normal lymphoblastoid cell line sample |
Lymphoblastoid cell line samples from healthy subjects. |