TOP TEN perturbations for 1553344_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553344_at
Selected probe(set): 1553344_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553344_at (1553344_at) across 6672 perturbations tested by GENEVESTIGATOR:

glioma study 17 (glioblastoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):-3.3957205
Number of Samples:3 / 3
Experimental glioma study 17 (glioblastoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from high grade glioblastoma (grade IV). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 66 ± 5 years old males.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (medulloblastoma)

Relative Expression (log2-ratio):2.5217113
Number of Samples:15 / 22
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.

brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (ependymoma)

Relative Expression (log2-ratio):2.452899
Number of Samples:15 / 46
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control brain tumor study 1 (ependymoma)
Primary tumor tissue sample from the brain of patients with ependymoma.

brain tumor study 1 (pilocytic astrocytoma) / normal brain tissue

Relative Expression (log2-ratio):2.4185662
Number of Samples:15 / 12
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

stem cell differentiation study 59 (iDRG; 12d) / normal embryonic stem cell sample (WA09)

Relative Expression (log2-ratio):1.9870667
Number of Samples:4 / 4
Experimental stem cell differentiation study 59 (iDRG; 12d)
Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 4 days. Further details are described in the paper.
Control normal embryonic stem cell sample (WA09)
Undifferentiated WA09 embryonic stem cell samples.

brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (glioblastoma)

Relative Expression (log2-ratio):1.9840989
Number of Samples:15 / 34
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control brain tumor study 1 (glioblastoma)
Primary tumor tissue sample from the brain of patients with glioblastoma multiformae.

oligodendrocyte progenitor cell study 2 (O4-;CD140a+) / oligodendrocyte progenitor cell study 2 (O4-;CD140a-)

Relative Expression (log2-ratio):1.809895
Number of Samples:5 / 5
Experimental oligodendrocyte progenitor cell study 2 (O4-;CD140a+)
Fetal oligodendrocyte cells between 20-22wk gestational age derived from fetal brains were FACS sorted on the basis of CD140a (PDGFRA) antigens. Samples were O4-/CD140a+.
Control oligodendrocyte progenitor cell study 2 (O4-;CD140a-)
Fetal oligodendrocyte cells between 20-22wk gestational age derived from fetal brains were FACS sorted on the basis of CD140a (PDGFRA) antigens. Samples were O4-/CD140a-.

stem cell differentiation study 59 (iDRG; 12d) / stem cell differentiation study 59 (8d)

Relative Expression (log2-ratio):1.6929941
Number of Samples:4 / 4
Experimental stem cell differentiation study 59 (iDRG; 12d)
Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 4 days. Further details are described in the paper.
Control stem cell differentiation study 59 (8d)
WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper.

glioma study 6 (epilepsy) / glioma study 6 (w/o epilepsy)

Relative Expression (log2-ratio):1.6592159
Number of Samples:5 / 3
Experimental glioma study 6 (epilepsy)
Adjacent peritumoral tumor tissue sample from the neocortical brain of patients with primary glioma and tumor induced epileptogenesis.
Control glioma study 6 (w/o epilepsy)
Adjacent peritumoral tumor tissue sample from the neocortical brain of patients with primary glioma and without tumor induced epileptogenesis.

stem cell differentiation study 59 (iDRG; 15d) / stem cell differentiation study 59 (iDRG; 12d)

Relative Expression (log2-ratio):-1.5353146
Number of Samples:4 / 4
Experimental stem cell differentiation study 59 (iDRG; 15d)
Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper.
Control stem cell differentiation study 59 (iDRG; 12d)
Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 4 days. Further details are described in the paper.