TOP TEN perturbations for 1553401_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553401_at
Selected probe(set): 1553401_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553401_at (1553401_at) across 6672 perturbations tested by GENEVESTIGATOR:

glioma study 17 (astrocytoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):-0.90472555
Number of Samples:3 / 3
Experimental glioma study 17 (astrocytoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from low grade astrocytoma (grade II). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 36 ± 7 years old.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

alopecia areata study 1 (AU; lesional; validation) / alopecia areata study 1 (AU; lesional; discovery)

Relative Expression (log2-ratio):0.72846794
Number of Samples:9 / 14
Experimental alopecia areata study 1 (AU; lesional; validation)
Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata universalis (AU) assigned to validation dataset.
Control alopecia areata study 1 (AU; lesional; discovery)
Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata universalis (AU) assigned to discovery dataset.

alopecia areata study 1 (AAP; non-lesional; validation) / alopecia areata study 1 (AAP; non-lesional; discovery)

Relative Expression (log2-ratio):0.6795049
Number of Samples:8 / 18
Experimental alopecia areata study 1 (AAP; non-lesional; validation)
Non-lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata patchy-type (AAP) assigned to validation dataset. Several patients had transient patchy type of AAP with dissease duration less than 1 year.
Control alopecia areata study 1 (AAP; non-lesional; discovery)
Non-lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata patchy-type (AAP) assigned to discovery dataset. Several patients had transient patchy type of AAP with dissease duration less than 1 year.

lung adenocarcinoma study 9 (metastase; lymph node) / lung adenocarcinoma study 9 (metastase; brain)

Relative Expression (log2-ratio):0.66325283
Number of Samples:3 / 6
Experimental lung adenocarcinoma study 9 (metastase; lymph node)
Metastatic tumor tissue obtained from the lymph node of patients with primary lung adenocarcinoma.
Control lung adenocarcinoma study 9 (metastase; brain)
Metastatic tumor tissue obtained from the brain of patients with primary lung adenocarcinoma.

alopecia areata study 1 (AAP; lesional; validation) / alopecia areata study 1 (AAP; lesional; discovery)

Relative Expression (log2-ratio):0.6423149
Number of Samples:8 / 19
Experimental alopecia areata study 1 (AAP; lesional; validation)
Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata patchy-type (AAP) assigned to validation dataset. Several patients had transient patchy type of AAP with dissease duration less than 1 year.
Control alopecia areata study 1 (AAP; lesional; discovery)
Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata patchy-type (AAP) assigned to discovery dataset. Several patients had transient patchy type of AAP with dissease duration less than 1 year.

ciclosporin study 6 (20uM) / vehicle (DMSO) treated HepG2 sample

Relative Expression (log2-ratio):0.62002563
Number of Samples:3 / 21
Experimental ciclosporin study 6 (20uM)
HepG2 cells treated with compound: cyclosporine A (INN: ciclosporin; 20uM; CAS no.:59865-13-3) for 24 hours. Ciclosporin is hepatotoxic and may cause cholestasis. HepG2 cells were treated with the IC20 concentration measured after 24 hours. ATC code:,
Control vehicle (DMSO) treated HepG2 sample
HepG2 cells treated with DMSO (0.5% v/v) as solvent control for 24 hours.

glioma study 17 (glioblastoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):-0.6110773
Number of Samples:3 / 3
Experimental glioma study 17 (glioblastoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from high grade glioblastoma (grade IV). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 66 ± 5 years old males.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

memory B cell study 1 (CD27high) / memory B cell study 1 (undivided)

Relative Expression (log2-ratio):0.5829592
Number of Samples:6 / 6
Experimental memory B cell study 1 (CD27high)
CD27 enriched proliferating human memory B cells expressing high level of CD27 (marker of antibody secretion) activated with CpG oligodeoxynucleotide (10 ng/ml), recombinant human cytokines IL-2 (20 IU/ml), IL-10 (50 ng/ml), IL-15 (10 ng/ml), recombinant human BAFF (75 ng/ml) in PC-L medium (IMDM medium, lacromin (50mg/ml), insulin (5mg/ml), penicillin/streptomycin, gentamicin (15mg/ml), normocin (0.1% v/v), 10% FCS) for 80 hours.
Control memory B cell study 1 (undivided)
CD27 enriched undivided human memory B cells (expressing low level of CD27) activated with CpG oligodeoxynucleotide (10 ng/ml), recombinant human cytokines IL-2 (20 IU/ml), IL-10 (50 ng/ml), IL-15 (10 ng/ml), recombinant human BAFF (75 ng/ml) in PC-L medium (IMDM medium, lacromin (50mg/ml), insulin (5mg/ml), penicillin/streptomycin, gentamicin (15mg/ml), normocin (0.1% v/v), 10% FCS) for 80 hours.

HIV-associated neurocognitive disorder study 6 (normal) / normal genu sample

Relative Expression (log2-ratio):0.57322884
Number of Samples:2 / 8
Experimental HIV-associated neurocognitive disorder study 6 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients did not receive any antiretroviral therapy (ART).
Control normal genu sample
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from healthy subjects.

systemic onset JIA study 4 / oligoarticular JIA study 3

Relative Expression (log2-ratio):0.557168
Number of Samples:3 / 12
Experimental systemic onset JIA study 4
Peripheral blood mononuclear cell (PBMC) samples from children with systemic onset of juvenile rheumatoid arthritis (JIA).
Control oligoarticular JIA study 3
Peripheral blood mononuclear cell (PBMC) samples from children with persistent oligoarthritis (oligoarticular JIA).