TOP TEN perturbations for 1553413_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1553413_at
Selected probe(set): 1553413_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1553413_at (1553413_at) across 6537 perturbations tested by GENEVESTIGATOR:
formaldehyde study 3 (4500ug/ml) / vehicle (EtOH) treated bronchial epithelial cell sample
Relative Expression (log2-ratio):3.8922424Number of Samples:3 / 3
Experimental | formaldehyde study 3 (4500ug/ml) |
Bronchial epithelial cells (NHBE) treated with 4500 ug/ml formaldehyde (within range of concentrations reported to induce toxicity in lung epithelial cells and other cell types) for 24 hours. NHBE cells were derived from a 60 year old male non-smoker. ATC code:--- | |
Control | vehicle (EtOH) treated bronchial epithelial cell sample |
Bronchial epithelial cells (NHBE) treated with vehicle (ethanol) at a final concentration of 2% v/v (concentration that ensures >80% cell viability after 24 hours of exposure) for 24 hours. NHBE cells were derived from a 60 year old male non-smoker. |
expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Relative Expression (log2-ratio):3.5883074Number of Samples:2 / 6
Experimental | expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the lung of patients with papillary adenocarcinoma (NOS). | |
Control | expO lung cancer study 1 (neuroendocrine carcinoma; primary) |
Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma. |
expO endometrial cancer study 1 (malignant mixed Mullerian tumor; primary) / expO endometrial cancer study 1 (adenocarcinoma, NOS; primary)
Relative Expression (log2-ratio):-3.2648869Number of Samples:13 / 4
Experimental | expO endometrial cancer study 1 (malignant mixed Mullerian tumor; primary) |
Primary tumor tissue samples obtained from the endometrium of patients with malignant mixed Mullerian tumor. | |
Control | expO endometrial cancer study 1 (adenocarcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the endometrium of patients with adenocarcinoma (NOS). |
expO endometrial cancer study 1 (endometrioid carcinoma; primary) / expO endometrial cancer study 1 (adenocarcinoma, NOS; primary)
Relative Expression (log2-ratio):-3.1658916Number of Samples:143 / 4
Experimental | expO endometrial cancer study 1 (endometrioid carcinoma; primary) |
Primary tumor tissue samples obtained from the endometrium of patients with endometrioid carcinoma. | |
Control | expO endometrial cancer study 1 (adenocarcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the endometrium of patients with adenocarcinoma (NOS). |
diabetes type 2 study 27 (LCM) / diabetes type 2 study 27 (enzymatic)
Relative Expression (log2-ratio):-2.9518385Number of Samples:34 / 19
Experimental | diabetes type 2 study 27 (LCM) |
Pancreatic islet samples obtained from type 2 diabetic (T2D) phenotyped pancreatectomized patients (PPP) and isolated by laser capture microdissection (LCM). Islets specimens were retrieved by LCM from snap-frozen surgical specimen from patients who underwent pancreatectomy for pancreatic diseases. Histopathology of the resected tissue did not reveal insulitis in any PPP. Patients age <18 years were excluded. Patients with type 2 diabetes had fasting glycemia ≥7.0 mmol/l; HbA1C ≥6.5% and history of diabetes for >1 year. | |
Control | diabetes type 2 study 27 (enzymatic) |
Pancreatic islet samples obtained from type 2 diabetic (T2D) patients and isolated by enzymatic digestion. Well-preserved islets were isolated by collagenase digestion of pancreas from brain-dead organ donors which suffered from type 2 diabetes. After 2±1 days of culture, islets were successfully hand-picked and processed for further analyses. Type 2 diabetes was diagnosed based on clinical history, treatment with glucose-lowering drugs, and lack of anti-GAD65 autoantibodies. |
HCC study 9 (HBV; HCV) / normal liver tissue
Relative Expression (log2-ratio):2.837885Number of Samples:2 / 10
Experimental | HCC study 9 (HBV; HCV) |
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection. | |
Control | normal liver tissue |
Normal, non-tumor liver tissue. |
IL-1b; IFN-g study 1 (132hrs) / untreated pancreatic islet sample (132hrs)
Relative Expression (log2-ratio):-2.691328Number of Samples:2 / 2
Experimental | IL-1b; IFN-g study 1 (132hrs) |
Pancreatic islets isolated by collagenase digestion from brain-dead organ donors and cultured 3-5 days in RPMI 1640 medium containing 5.6 mM glucose, 10% FCS and 2 mM L-glutamine. Thereafter, islets were cultured in presence of human recombinant IL-1b (25 units/ml) and IFN-g (1,000 units/ml) for 132 hours. Media were changed after 2 and 5 days. | |
Control | untreated pancreatic islet sample (132hrs) |
Untreated pancreatic islets isolated by collagenase digestion from brain-dead organ donors and cultured 3-5 days in RPMI 1640 medium containing 5.6 mM glucose, 10% FCS and 2 mM L-glutamine. Thereafter, islets were cultured in fresh media and harvested after 132 hours. Media were changed after 2 and 5 days. |
expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO lung cancer study 1 (bronchiolo-alveolar adenocarcinoma; primary)
Relative Expression (log2-ratio):2.6373596Number of Samples:2 / 13
Experimental | expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the lung of patients with papillary adenocarcinoma (NOS). | |
Control | expO lung cancer study 1 (bronchiolo-alveolar adenocarcinoma; primary) |
Primary tumor tissue samples obtained from the lung of patients with bronchiolo-alveolar adenocarcinoma. |
smoking study 11 (late) / filtered air treated bronchial epithelial cell sample (non-smoker)
Relative Expression (log2-ratio):2.5543642Number of Samples:9 / 9
Experimental | smoking study 11 (late) |
Bronchial epithelial cells from non-smoker donors exposed to 1:50 dose (1.84ug/cm2) of diluted mainstream cigarette smoke for 1 hour following a 23 hours recovery period. | |
Control | filtered air treated bronchial epithelial cell sample (non-smoker) |
Bronchial epithelial cells from non-smoker donors exposed to filtered for 1 hour following a 23 hours recovery period. |
lung adenocarcinoma study 3 / adjacent lung tissue
Relative Expression (log2-ratio):2.5217943Number of Samples:93 / 98
Experimental | lung adenocarcinoma study 3 |
Primary adenocarcinoma samples from the lung of patients with different stages and smoking status. | |
Control | adjacent lung tissue |
Adjacent, histologically normal and non-neoplastic tissue sample from the lung of patients with primary adenocarcinoma of the lung. Patients had different stages and smoking status. |