TOP TEN perturbations for 1553413_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553413_at
Selected probe(set): 1553413_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553413_at (1553413_at) across 6537 perturbations tested by GENEVESTIGATOR:

formaldehyde study 3 (4500ug/ml) / vehicle (EtOH) treated bronchial epithelial cell sample

Relative Expression (log2-ratio):3.8922424
Number of Samples:3 / 3
Experimental formaldehyde study 3 (4500ug/ml)
Bronchial epithelial cells (NHBE) treated with 4500 ug/ml formaldehyde (within range of concentrations reported to induce toxicity in lung epithelial cells and other cell types) for 24 hours. NHBE cells were derived from a 60 year old male non-smoker. ATC code:---
Control vehicle (EtOH) treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) treated with vehicle (ethanol) at a final concentration of 2% v/v (concentration that ensures >80% cell viability after 24 hours of exposure) for 24 hours. NHBE cells were derived from a 60 year old male non-smoker.

expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO lung cancer study 1 (neuroendocrine carcinoma; primary)

Relative Expression (log2-ratio):3.5883074
Number of Samples:2 / 6
Experimental expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the lung of patients with papillary adenocarcinoma (NOS).
Control expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma.

expO endometrial cancer study 1 (malignant mixed Mullerian tumor; primary) / expO endometrial cancer study 1 (adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-3.2648869
Number of Samples:13 / 4
Experimental expO endometrial cancer study 1 (malignant mixed Mullerian tumor; primary)
Primary tumor tissue samples obtained from the endometrium of patients with malignant mixed Mullerian tumor.
Control expO endometrial cancer study 1 (adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the endometrium of patients with adenocarcinoma (NOS).

expO endometrial cancer study 1 (endometrioid carcinoma; primary) / expO endometrial cancer study 1 (adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-3.1658916
Number of Samples:143 / 4
Experimental expO endometrial cancer study 1 (endometrioid carcinoma; primary)
Primary tumor tissue samples obtained from the endometrium of patients with endometrioid carcinoma.
Control expO endometrial cancer study 1 (adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the endometrium of patients with adenocarcinoma (NOS).

diabetes type 2 study 27 (LCM) / diabetes type 2 study 27 (enzymatic)

Relative Expression (log2-ratio):-2.9518385
Number of Samples:34 / 19
Experimental diabetes type 2 study 27 (LCM)
Pancreatic islet samples obtained from type 2 diabetic (T2D) phenotyped pancreatectomized patients (PPP) and isolated by laser capture microdissection (LCM). Islets specimens were retrieved by LCM from snap-frozen surgical specimen from patients who underwent pancreatectomy for pancreatic diseases. Histopathology of the resected tissue did not reveal insulitis in any PPP. Patients age <18 years were excluded. Patients with type 2 diabetes had fasting glycemia ≥7.0 mmol/l; HbA1C ≥6.5% and history of diabetes for >1 year.
Control diabetes type 2 study 27 (enzymatic)
Pancreatic islet samples obtained from type 2 diabetic (T2D) patients and isolated by enzymatic digestion. Well-preserved islets were isolated by collagenase digestion of pancreas from brain-dead organ donors which suffered from type 2 diabetes. After 2±1 days of culture, islets were successfully hand-picked and processed for further analyses. Type 2 diabetes was diagnosed based on clinical history, treatment with glucose-lowering drugs, and lack of anti-GAD65 autoantibodies.

HCC study 9 (HBV; HCV) / normal liver tissue

Relative Expression (log2-ratio):2.837885
Number of Samples:2 / 10
Experimental HCC study 9 (HBV; HCV)
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

IL-1b; IFN-g study 1 (132hrs) / untreated pancreatic islet sample (132hrs)

Relative Expression (log2-ratio):-2.691328
Number of Samples:2 / 2
Experimental IL-1b; IFN-g study 1 (132hrs)
Pancreatic islets isolated by collagenase digestion from brain-dead organ donors and cultured 3-5 days in RPMI 1640 medium containing 5.6 mM glucose, 10% FCS and 2 mM L-glutamine. Thereafter, islets were cultured in presence of human recombinant IL-1b (25 units/ml) and IFN-g (1,000 units/ml) for 132 hours. Media were changed after 2 and 5 days.
Control untreated pancreatic islet sample (132hrs)
Untreated pancreatic islets isolated by collagenase digestion from brain-dead organ donors and cultured 3-5 days in RPMI 1640 medium containing 5.6 mM glucose, 10% FCS and 2 mM L-glutamine. Thereafter, islets were cultured in fresh media and harvested after 132 hours. Media were changed after 2 and 5 days.

expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO lung cancer study 1 (bronchiolo-alveolar adenocarcinoma; primary)

Relative Expression (log2-ratio):2.6373596
Number of Samples:2 / 13
Experimental expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the lung of patients with papillary adenocarcinoma (NOS).
Control expO lung cancer study 1 (bronchiolo-alveolar adenocarcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with bronchiolo-alveolar adenocarcinoma.

smoking study 11 (late) / filtered air treated bronchial epithelial cell sample (non-smoker)

Relative Expression (log2-ratio):2.5543642
Number of Samples:9 / 9
Experimental smoking study 11 (late)
Bronchial epithelial cells from non-smoker donors exposed to 1:50 dose (1.84ug/cm2) of diluted mainstream cigarette smoke for 1 hour following a 23 hours recovery period.
Control filtered air treated bronchial epithelial cell sample (non-smoker)
Bronchial epithelial cells from non-smoker donors exposed to filtered for 1 hour following a 23 hours recovery period.

lung adenocarcinoma study 3 / adjacent lung tissue

Relative Expression (log2-ratio):2.5217943
Number of Samples:93 / 98
Experimental lung adenocarcinoma study 3
Primary adenocarcinoma samples from the lung of patients with different stages and smoking status.
Control adjacent lung tissue
Adjacent, histologically normal and non-neoplastic tissue sample from the lung of patients with primary adenocarcinoma of the lung. Patients had different stages and smoking status.