TOP TEN perturbations for 1553447_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553447_at
Selected probe(set): 1553447_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553447_at (1553447_at) across 6537 perturbations tested by GENEVESTIGATOR:

myotonic dystrophy study 4 (skeletal muscle; DM2) / normal skeletal muscle tissue (adult)

Relative Expression (log2-ratio):2.447423
Number of Samples:8 / 6
Experimental myotonic dystrophy study 4 (skeletal muscle; DM2)
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2).
Control normal skeletal muscle tissue (adult)
Commercially purchased normal adult skeletal muscle tissue samples.

OXPHOS disorder study 1 (middle) / control muscle (middle)

Relative Expression (log2-ratio):2.2060862
Number of Samples:2 / 4
Experimental OXPHOS disorder study 1 (middle)
Skeletal muscle biopsies obtained from young patients (23 and 36 years old) with oxidative phosphorylation system deficiency (OXPHOS disorder). All patients exhibited mutations in the catalytic DNA polymerase gamma (POLG1) gene.
Control control muscle (middle)
Skeletal muscle biopsies obtained from control middle-aged subjects that were 17 to 34 years old.

necrotizing myopathy study 1 / inclusion body myositis study 1

Relative Expression (log2-ratio):2.1750412
Number of Samples:3 / 5
Experimental necrotizing myopathy study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of necrotizing myopathy (NM).
Control inclusion body myositis study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).

myotonic dystrophy study 4 (biceps brachii; DM-like) / normal skeletal muscle tissue (adult)

Relative Expression (log2-ratio):2.1349144
Number of Samples:9 / 6
Experimental myotonic dystrophy study 4 (biceps brachii; DM-like)
Biceps brachii biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion).
Control normal skeletal muscle tissue (adult)
Commercially purchased normal adult skeletal muscle tissue samples.

myotonic dystrophy study 4 (skeletal muscle; DM1) / normal skeletal muscle tissue (adult)

Relative Expression (log2-ratio):2.0893126
Number of Samples:5 / 6
Experimental myotonic dystrophy study 4 (skeletal muscle; DM1)
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 1 (DM1).
Control normal skeletal muscle tissue (adult)
Commercially purchased normal adult skeletal muscle tissue samples.

myotonic dystrophy study 4 (biceps brachii; DM2) / normal skeletal muscle tissue (adult)

Relative Expression (log2-ratio):2.0789309
Number of Samples:3 / 6
Experimental myotonic dystrophy study 4 (biceps brachii; DM2)
Biceps brachii biopsies obtained from patients with myotonic dystrophy type 2 (DM2).
Control normal skeletal muscle tissue (adult)
Commercially purchased normal adult skeletal muscle tissue samples.

myotonic dystrophy study 2 (DM2) / normal skeletal muscle tissue

Relative Expression (log2-ratio):1.815341
Number of Samples:20 / 6
Experimental myotonic dystrophy study 2 (DM2)
Muscle biopsies from patients with myotonic dystrophy type 2 (DM2). The disease was diagnosed by DNA mutation testing.
Control normal skeletal muscle tissue
Muscle biopsies from normal individuals.

myotonic dystrophy study 2 (DM1) / normal skeletal muscle tissue

Relative Expression (log2-ratio):1.714077
Number of Samples:10 / 6
Experimental myotonic dystrophy study 2 (DM1)
Muscle biopsies from patients with myotonic dystrophy type 1 (DM1). The disease was diagnosed by DNA mutation testing.
Control normal skeletal muscle tissue
Muscle biopsies from normal individuals.

Becker muscular dystrophy study 3 (biceps brachii) / normal skeletal muscle tissue (adult)

Relative Expression (log2-ratio):1.680439
Number of Samples:3 / 6
Experimental Becker muscular dystrophy study 3 (biceps brachii)
Biceps brachii biopsies obtained from patients with Becker muscular dystrophy (BMD).
Control normal skeletal muscle tissue (adult)
Commercially purchased normal adult skeletal muscle tissue samples.

polymyositis study 1 / necrotizing myopathy study 1

Relative Expression (log2-ratio):-1.5413103
Number of Samples:5 / 3
Experimental polymyositis study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of polymyositis (PM).
Control necrotizing myopathy study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of necrotizing myopathy (NM).