TOP TEN perturbations for 1553447_at (Homo sapiens)
Organism: Homo sapiens
Gene: 1553447_at
Selected probe(set): 1553447_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 1553447_at (1553447_at) across 6537 perturbations tested by GENEVESTIGATOR:
myotonic dystrophy study 4 (skeletal muscle; DM2) / normal skeletal muscle tissue (adult)
Relative Expression (log2-ratio):2.447423Number of Samples:8 / 6
Experimental | myotonic dystrophy study 4 (skeletal muscle; DM2) |
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tissue (adult) |
Commercially purchased normal adult skeletal muscle tissue samples. |
OXPHOS disorder study 1 (middle) / control muscle (middle)
Relative Expression (log2-ratio):2.2060862Number of Samples:2 / 4
Experimental | OXPHOS disorder study 1 (middle) |
Skeletal muscle biopsies obtained from young patients (23 and 36 years old) with oxidative phosphorylation system deficiency (OXPHOS disorder). All patients exhibited mutations in the catalytic DNA polymerase gamma (POLG1) gene. | |
Control | control muscle (middle) |
Skeletal muscle biopsies obtained from control middle-aged subjects that were 17 to 34 years old. |
necrotizing myopathy study 1 / inclusion body myositis study 1
Relative Expression (log2-ratio):2.1750412Number of Samples:3 / 5
Experimental | necrotizing myopathy study 1 |
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of necrotizing myopathy (NM). | |
Control | inclusion body myositis study 1 |
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM). |
myotonic dystrophy study 4 (biceps brachii; DM-like) / normal skeletal muscle tissue (adult)
Relative Expression (log2-ratio):2.1349144Number of Samples:9 / 6
Experimental | myotonic dystrophy study 4 (biceps brachii; DM-like) |
Biceps brachii biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion). | |
Control | normal skeletal muscle tissue (adult) |
Commercially purchased normal adult skeletal muscle tissue samples. |
myotonic dystrophy study 4 (skeletal muscle; DM1) / normal skeletal muscle tissue (adult)
Relative Expression (log2-ratio):2.0893126Number of Samples:5 / 6
Experimental | myotonic dystrophy study 4 (skeletal muscle; DM1) |
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 1 (DM1). | |
Control | normal skeletal muscle tissue (adult) |
Commercially purchased normal adult skeletal muscle tissue samples. |
myotonic dystrophy study 4 (biceps brachii; DM2) / normal skeletal muscle tissue (adult)
Relative Expression (log2-ratio):2.0789309Number of Samples:3 / 6
Experimental | myotonic dystrophy study 4 (biceps brachii; DM2) |
Biceps brachii biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tissue (adult) |
Commercially purchased normal adult skeletal muscle tissue samples. |
myotonic dystrophy study 2 (DM2) / normal skeletal muscle tissue
Relative Expression (log2-ratio):1.815341Number of Samples:20 / 6
Experimental | myotonic dystrophy study 2 (DM2) |
Muscle biopsies from patients with myotonic dystrophy type 2 (DM2). The disease was diagnosed by DNA mutation testing. | |
Control | normal skeletal muscle tissue |
Muscle biopsies from normal individuals. |
myotonic dystrophy study 2 (DM1) / normal skeletal muscle tissue
Relative Expression (log2-ratio):1.714077Number of Samples:10 / 6
Experimental | myotonic dystrophy study 2 (DM1) |
Muscle biopsies from patients with myotonic dystrophy type 1 (DM1). The disease was diagnosed by DNA mutation testing. | |
Control | normal skeletal muscle tissue |
Muscle biopsies from normal individuals. |
Becker muscular dystrophy study 3 (biceps brachii) / normal skeletal muscle tissue (adult)
Relative Expression (log2-ratio):1.680439Number of Samples:3 / 6
Experimental | Becker muscular dystrophy study 3 (biceps brachii) |
Biceps brachii biopsies obtained from patients with Becker muscular dystrophy (BMD). | |
Control | normal skeletal muscle tissue (adult) |
Commercially purchased normal adult skeletal muscle tissue samples. |
polymyositis study 1 / necrotizing myopathy study 1
Relative Expression (log2-ratio):-1.5413103Number of Samples:5 / 3
Experimental | polymyositis study 1 |
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of polymyositis (PM). | |
Control | necrotizing myopathy study 1 |
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of necrotizing myopathy (NM). |