TOP TEN perturbations for 1553448_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553448_at
Selected probe(set): 1553448_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553448_at (1553448_at) across 6672 perturbations tested by GENEVESTIGATOR:

lung adenocarcinoma study 6 (K-RAS mut) / adjacent lung tissue

Relative Expression (log2-ratio):-2.046824
Number of Samples:6 / 20
Experimental lung adenocarcinoma study 6 (K-RAS mut)
Primary tumor sample from patients with stage II adenocarcinoma carrying a K-RAS mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

lung adenocarcinoma study 6 (EGFR mut) / adjacent lung tissue

Relative Expression (log2-ratio):-1.916956
Number of Samples:24 / 20
Experimental lung adenocarcinoma study 6 (EGFR mut)
Primary tumor sample from patients with stage II adenocarcinoma carrying an EGFR mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

lung adenocarcinoma study 5 (EML4-ALK) / adjacent lung tissue

Relative Expression (log2-ratio):-1.8221283
Number of Samples:3 / 20
Experimental lung adenocarcinoma study 5 (EML4-ALK)
Primary tumor sample from patients with stage I adenocarcinoma carrying the EML4-ALK-fusion.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

lung adenocarcinoma study 5 (K-RAS mut) / adjacent lung tissue

Relative Expression (log2-ratio):-1.7939234
Number of Samples:14 / 20
Experimental lung adenocarcinoma study 5 (K-RAS mut)
Primary tumor sample from patients with stage I adenocarcinoma carrying a K-RAS mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

lung adenocarcinoma study 5 (EGFR/K-RAS/ALK -) / adjacent lung tissue

Relative Expression (log2-ratio):-1.6414237
Number of Samples:48 / 20
Experimental lung adenocarcinoma study 5 (EGFR/K-RAS/ALK -)
Primary tumor sample from patients with triple-negative stage I adenocarcinoma of the lung. The patients were not carrying any mutation in the EGFR, K- RAS or ALK gene.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

lung adenocarcinoma study 6 (EML4-ALK) / adjacent lung tissue

Relative Expression (log2-ratio):-1.5975032
Number of Samples:8 / 20
Experimental lung adenocarcinoma study 6 (EML4-ALK)
Primary tumor sample from patients with stage II adenocarcinoma carrying the EML4-ALK-fusion.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

CPFE study 1 (fibrous) / CPFE study 1 (emphysematous)

Relative Expression (log2-ratio):-1.5847087
Number of Samples:3 / 3
Experimental CPFE study 1 (fibrous)
Fibrous lesional lung tissue sample obtained from patients with combined pulmonary fibrosis and emphysema (CFPE). Individuals were all male and former smokers (smoking from 38 - 72 pack years) having primary lung cancer. The fibrous lesions were located within the resected lobes obtained after lobectomy.
Control CPFE study 1 (emphysematous)
Emphysematous lesional lung tissue sample obtained from patients with combined pulmonary fibrosis and emphysema (CFPE). Individuals were all male and former smokers (smoking from 38 - 72 pack years) having primary lung cancer. The emphysematous lesions were located within the resected lobes obtained after lobectomy.

lung adenocarcinoma study 5 (EGFR mut) / adjacent lung tissue

Relative Expression (log2-ratio):-1.5716863
Number of Samples:103 / 20
Experimental lung adenocarcinoma study 5 (EGFR mut)
Primary tumor sample from patients with stage I adenocarcinoma carrying an EGFR mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

lung adenocarcinoma study 6 (EGFR/K-RAS/ALK -) / adjacent lung tissue

Relative Expression (log2-ratio):-1.5358438
Number of Samples:20 / 20
Experimental lung adenocarcinoma study 6 (EGFR/K-RAS/ALK -)
Primary tumor sample from patients with triple-negative stage II adenocarcinoma of the lung. The patients were not carrying any mutation in the EGFR, K- RAS or ALK gene.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

nephroblastoma study 2 / normal kidney tissue

Relative Expression (log2-ratio):-1.2777758
Number of Samples:4 / 2
Experimental nephroblastoma study 2
Tumor tissue samples from the kidney of patients with Wilms’ tumor.
Control normal kidney tissue
Normal fetal kidney tissue samples.