TOP TEN perturbations for 1553539_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553539_at
Selected probe(set): 231583_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553539_at (231583_at) across 6673 perturbations tested by GENEVESTIGATOR:

alopecia areata study 1 (AT; lesional; validation) / normal skin tissue (validation)

Relative Expression (log2-ratio):-3.5464706
Number of Samples:3 / 13
Experimental alopecia areata study 1 (AT; lesional; validation)
Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata totalis (AT) assigned to validation dataset.
Control normal skin tissue (validation)
Scalp skin punch biopsies obtained from healthy donors assigned to validation dataset.

alopecia areata study 1 (AAP; lesional; validation) / alopecia areata study 1 (AT; lesional; validation)

Relative Expression (log2-ratio):3.1948566
Number of Samples:8 / 3
Experimental alopecia areata study 1 (AAP; lesional; validation)
Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata patchy-type (AAP) assigned to validation dataset. Several patients had transient patchy type of AAP with dissease duration less than 1 year.
Control alopecia areata study 1 (AT; lesional; validation)
Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata totalis (AT) assigned to validation dataset.

RAF1 depletion study 1 / control vector transfected SW-480 cell sample

Relative Expression (log2-ratio):-2.9065323
Number of Samples:6 / 6
Experimental RAF1 depletion study 1
RNAi-mediated gene knockdown of RAF1 in colorectal cancer cell line SW-480.
Control control vector transfected SW-480 cell sample
SW-480 colorectal cell line sample transduced with empty vector pLKO.

SW620 / SW480

Relative Expression (log2-ratio):-2.819252
Number of Samples:62 / 63
Experimental SW620
Human metastatic cancer cell line derived from the lymph node of a patient with adenocarcinoma of the colon. Synonyms:SW-620; SW 620; SW.620 Cellosaurus code:
Control SW480
Human primary cancer cell line derived from the colon of a male patient with adenocarcinoma. Synonyms:SW-480; SW 480; SW480E Cellosaurus code:

alopecia areata study 1 (AU; lesional; validation) / normal skin tissue (validation)

Relative Expression (log2-ratio):-2.7015991
Number of Samples:9 / 13
Experimental alopecia areata study 1 (AU; lesional; validation)
Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata universalis (AU) assigned to validation dataset.
Control normal skin tissue (validation)
Scalp skin punch biopsies obtained from healthy donors assigned to validation dataset.

thermal injury study 1 (0-3d) / normal skin tissue

Relative Expression (log2-ratio):-2.691822
Number of Samples:3 / 3
Experimental thermal injury study 1 (0-3d)
Burn wound margin samples of the skin 0-3 days post thermal injury.
Control normal skin tissue
Normal skin tissue sample.

thermal injury study 1 (>7d) / normal skin tissue

Relative Expression (log2-ratio):-2.672429
Number of Samples:3 / 3
Experimental thermal injury study 1 (>7d)
Burn wound margin samples of the skin >7 days post thermal injury.
Control normal skin tissue
Normal skin tissue sample.

RAF1 depletion study 1 / mock transfected SW-480 cell sample

Relative Expression (log2-ratio):-2.6570654
Number of Samples:6 / 6
Experimental RAF1 depletion study 1
RNAi-mediated gene knockdown of RAF1 in colorectal cancer cell line SW-480.
Control mock transfected SW-480 cell sample
SW-480 colorectal cell line sample transduced with non-targeting pLKO_NonTarget vector.

thermal injury study 1 (4-7d) / normal skin tissue

Relative Expression (log2-ratio):-2.6013527
Number of Samples:3 / 3
Experimental thermal injury study 1 (4-7d)
Burn wound margin samples of the skin 4-7 days post thermal injury.
Control normal skin tissue
Normal skin tissue sample.

Merkel cell carcinoma study 3 (primary) / normal skin tissue

Relative Expression (log2-ratio):-2.5753012
Number of Samples:19 / 64
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control normal skin tissue
Normal skin samples from healthy donors.