TOP TEN perturbations for 1553566_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553566_at
Selected probe(set): 228165_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553566_at (228165_at) across 6672 perturbations tested by GENEVESTIGATOR:

medulloblastoma study 2 / non-tumor brain tissue

Relative Expression (log2-ratio):-2.4707375
Number of Samples:4 / 9
Experimental medulloblastoma study 2
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

HIV-associated neurocognitive disorder study 7 (normal) / HIV-associated neurocognitive disorder study 6 (normal)

Relative Expression (log2-ratio):2.2325277
Number of Samples:2 / 2
Experimental HIV-associated neurocognitive disorder study 7 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients received antiretroviral therapy (ART).
Control HIV-associated neurocognitive disorder study 6 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients did not receive any antiretroviral therapy (ART).

HIV-associated neurocognitive disorder study 9 (HIVE) / HIV-associated dementia study 1

Relative Expression (log2-ratio):-2.2021475
Number of Samples:5 / 7
Experimental HIV-associated neurocognitive disorder study 9 (HIVE)
Postmortem cerebral white matter tissue from HIV-1-infected patients with substantial HIV-associated neurocognitive impairment (HAND). Patients had no encephalitis (HIVE) or other neuropathological defect.
Control HIV-associated dementia study 1
Postmortem basal ganglia tissue from HIV-1-infected patients with substantial HIV-associated neurocognitive impairment (HAND). Patients had no encephalitis (HIVE) or other neuropathological defect.

atypical teratoid/rhabdoid tumor study 1 / non-tumor brain tissue

Relative Expression (log2-ratio):-1.9458342
Number of Samples:20 / 9
Experimental atypical teratoid/rhabdoid tumor study 1
Primary tumor tissue sample from the brain of pediatric patients with atypical teratoid/rhabdoid tumor (AT/RT).
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

StarPap depletion study 1 (siRNA) / control siRNA transfected HEK293 cell sample

Relative Expression (log2-ratio):-1.7999144
Number of Samples:3 / 3
Experimental StarPap depletion study 1 (siRNA)
HEK293 cells were transfected with siRNA specific for StarPap.
Control control siRNA transfected HEK293 cell sample
HEK293 cells were transfected with control siRNA.

brain tumor study 1 (medulloblastoma) / normal brain tissue

Relative Expression (log2-ratio):-1.6729441
Number of Samples:22 / 12
Experimental brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

medulloblastoma study 1 / non-tumor brain tissue

Relative Expression (log2-ratio):-1.6640415
Number of Samples:17 / 9
Experimental medulloblastoma study 1
Primary tumor tissue sample from the infratentorial brain of pediatric patients with classical medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

HIF-1a/HIF-2a depletion study 1 (normoxia; AB81) / control AB81 cell sample (normoxia)

Relative Expression (log2-ratio):-1.6468267
Number of Samples:3 / 3
Experimental HIF-1a/HIF-2a depletion study 1 (normoxia; AB81)
Human podocyte cells AB81 with shRNA-mediated stable knock-down of HIF-1a and HIF-2a (Hypoxia-inducible factor 1-alpha and Hypoxia-inducible factor 2-alpha) 24 hours after treatment with normoxia (20% O2). Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates.
Control control AB81 cell sample (normoxia)
Human podocyte cell line AB81 treated with normoxia (20% O2) for 24 hours. Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates.

atypical teratoid/rhabdoid tumor study 1 / primitive neuroectodermal tumor study 1

Relative Expression (log2-ratio):-1.6171951
Number of Samples:20 / 9
Experimental atypical teratoid/rhabdoid tumor study 1
Primary tumor tissue sample from the brain of pediatric patients with atypical teratoid/rhabdoid tumor (AT/RT).
Control primitive neuroectodermal tumor study 1
Primary tumor tissue sample from the supratentorial brain of pediatric patients with primitive neuroectodermal tumor.

engineered skin substitute study 2 (intermediate) / engineered skin substitute study 1 (intermediate)

Relative Expression (log2-ratio):1.5770931
Number of Samples:6 / 3
Experimental engineered skin substitute study 2 (intermediate)
Human skin substitutes tissue samples collected after 14 and 28 days after transplantation to athymic mice.
Control engineered skin substitute study 1 (intermediate)
Human skin substitutes tissue samples collected after 7 days in culture.