TOP TEN perturbations for 1553600_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553600_at
Selected probe(set): 1553601_a_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553600_at (1553601_a_at) across 6672 perturbations tested by GENEVESTIGATOR:

rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium) / focal segmental glomerulosclerosis study 9 (glomerulus)

Relative Expression (log2-ratio):-5.257036
Number of Samples:21 / 10
Experimental rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium)
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from rapidly progressive glomerulonephritis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Donors were positive for ANCA-antibody. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control focal segmental glomerulosclerosis study 9 (glomerulus)
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.

bone cancer study 1 (PDX; chondrosarcoma, NOS; primary) / bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)

Relative Expression (log2-ratio):2.782939
Number of Samples:2 / 2
Experimental bone cancer study 1 (PDX; chondrosarcoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary chondrosarcoma, NOS of the bone (subcutaneously implanted).
Control bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary myxoid chondrosarcoma of the bone (subcutaneously implanted).

brain tumor study 1 (medulloblastoma) / brain tumor study 1 (ependymoma)

Relative Expression (log2-ratio):-2.6364746
Number of Samples:22 / 46
Experimental brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.
Control brain tumor study 1 (ependymoma)
Primary tumor tissue sample from the brain of patients with ependymoma.

bone cancer study 1 (PDX; chondrosarcoma, NOS; primary) / bone cancer study 1 (PDX; osteosarcoma, NOS; primary)

Relative Expression (log2-ratio):2.540608
Number of Samples:2 / 2
Experimental bone cancer study 1 (PDX; chondrosarcoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary chondrosarcoma, NOS of the bone (subcutaneously implanted).
Control bone cancer study 1 (PDX; osteosarcoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary osteosarcoma, NOS of the bone (subcutaneously implanted).

vitamin A study 3 (10nM; 18h) / vehicle treated peripheral blood monocyte sample (18h)

Relative Expression (log2-ratio):2.477148
Number of Samples:4 / 4
Experimental vitamin A study 3 (10nM; 18h)
Peripheral blood monocyte samples derived from blood of healthy donors and treated with 10 nM ATRA (all-trans retinoic acid, biologically active form of vitamin A) for 18 h. ATC code:---
Control vehicle treated peripheral blood monocyte sample (18h)
Peripheral blood monocyte samples derived from blood of healthy donors and treated with vehicle for 18 h.

calcitriol study 7 (10nM; 18h) / vitamin A study 3 (10nM; 18h)

Relative Expression (log2-ratio):-2.4599524
Number of Samples:4 / 4
Experimental calcitriol study 7 (10nM; 18h)
Peripheral blood monocyte samples derived from blood of healthy donors and treated with 10 nM calcitriol (1alpha, 25-Dihydroxyvitamin D3; 1,25(OH)2D3) for 18 h. ATC code:,
Control vitamin A study 3 (10nM; 18h)
Peripheral blood monocyte samples derived from blood of healthy donors and treated with 10 nM ATRA (all-trans retinoic acid, biologically active form of vitamin A) for 18 h. ATC code:---

TNF-ɑ study 5 (late) / TNF-ɑ study 5 (early)

Relative Expression (log2-ratio):-2.1463828
Number of Samples:3 / 3
Experimental TNF-ɑ study 5 (late)
ARPE-19 retina pigment epithelial cell samples treated with TNF-ɑ (10 ng/ml). Samples were taken 42 hours after treatment.
Control TNF-ɑ study 5 (early)
ARPE-19 retina pigment epithelial cell samples treated with TNF-ɑ (10 ng/ml). Samples were taken 6 hours after treatment.

brain tumor study 1 (medulloblastoma) / normal brain tissue

Relative Expression (log2-ratio):-2.0695505
Number of Samples:22 / 12
Experimental brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):-1.9616289
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37°C in humidified air containing 5% CO2.

gonadotroph adenoma study 1 / normal pituitary gland tissue

Relative Expression (log2-ratio):1.9321203
Number of Samples:7 / 8
Experimental gonadotroph adenoma study 1
Gonadotroph adenoma biopsy samples recovered during transsphenoidal surgery. The tumors were defined as demonstrating positive immunostaining for FSH, LH, or alpha subunit in greater than 5-10% of cells. Samples were scanned between 04/6/2004 - 15/4/2005.
Control normal pituitary gland tissue
Biopsy samples of healthy pituitary gland recovered post-mortem during autopsy within 2-18 hours of death. Cause of death were mostly various pulmonary or cardiovascular conditions.