TOP TEN perturbations for 1553719_s_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1553719_s_at
Selected probe(set): 1553718_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1553719_s_at (1553718_at) across 6622 perturbations tested by GENEVESTIGATOR:

ovarian tumor study 11 (low grade) / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):-4.0242996
Number of Samples:11 / 6
Experimental ovarian tumor study 11 (low grade)
Human microdissected tumor cells from the ovary of patients with low grade serous carcinoma.
Control normal ovarian surface epithelial cell sample
Human microdissected ovarian surface epithelial cell sample from the ovary of healthy individuals.

ovarian tumor study 11 (high grade) / ovarian tumor study 11 (low grade)

Relative Expression (log2-ratio):3.4493618
Number of Samples:22 / 11
Experimental ovarian tumor study 11 (high grade)
Human microdissected tumor cells from the ovary of patients with high grade serous carcinoma.
Control ovarian tumor study 11 (low grade)
Human microdissected tumor cells from the ovary of patients with low grade serous carcinoma.

ovarian tumor study 17 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):-2.8369198
Number of Samples:9 / 10
Experimental ovarian tumor study 17
Human epithelial tumor cell samples from the ovary of patients with primary clear cell carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue from donors with non-cancerous, benign gynecological diseases.

prediabetes type 1 study 1 (clinical) / normal blood sample

Relative Expression (log2-ratio):2.7277946
Number of Samples:21 / 16
Experimental prediabetes type 1 study 1 (clinical)
Whole blood samples from longitudinal study of children presenting with type 1 diabetes (T1D) -associated autoantibodies. The patients developed T1D at the end of the study; T1D present at first-degree relatives.
Control normal blood sample
Whole blood sample from children persistently negative for type 1 diabetes autoantibodies. The subjects were matched for gender, age and HLA-genotype.

diabetes type 1 study 7 / normal blood sample

Relative Expression (log2-ratio):2.5532904
Number of Samples:3 / 16
Experimental diabetes type 1 study 7
Whole blood samples from longitudinal study of children presenting with type 1 diabetes (T1D) -associated autoantibodies, who were classified with T1D at this point; T1D present at first-degree relatives.
Control normal blood sample
Whole blood sample from children persistently negative for type 1 diabetes autoantibodies. The subjects were matched for gender, age and HLA-genotype.

connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; metastatic) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic)

Relative Expression (log2-ratio):-2.461381
Number of Samples:2 / 2
Experimental connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; metastatic)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, leiomyosarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported.
Control connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, clear cell sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported.

dengue fever study 10 (DHF) / normal naive CD8 T cell sample

Relative Expression (log2-ratio):-2.3527603
Number of Samples:2 / 5
Experimental dengue fever study 10 (DHF)
Activated CD8 T cells derived from peripheral blood mononuclear cells (PBMCs) of Thai individuals with Dengue hemorrhagic fever (DF) characterized by the WHO 1997. FACS-sorted CD3+, CD8+, HLA_DR+, and CD38+ effector CD8 T subtype cells were used for analysis.
Control normal naive CD8 T cell sample
Normal naive CD8 T cells derived from peripheral blood mononuclear cells (PBMCs) of healthy Thai individuals. FACS-sorted CD3+, CD8+, CD45RA+, and CCR7+ naive CD8 T subtype cells were used for analysis.

ovarian tumor study 11 (low grade) / ovarian tumor study 11 (borderline)

Relative Expression (log2-ratio):-2.2803812
Number of Samples:11 / 8
Experimental ovarian tumor study 11 (low grade)
Human microdissected tumor cells from the ovary of patients with low grade serous carcinoma.
Control ovarian tumor study 11 (borderline)
Human microdissected tumor cells from the ovary of patients with low-malignant (borderline) tumors of the ovary.

conditioned medium study 1 (HS27a) / untreated monocyte (CD14+) sample

Relative Expression (log2-ratio):-2.2279606
Number of Samples:2 / 2
Experimental conditioned medium study 1 (HS27a)
CD14+ monocytes treated with HS27a conditioned medium (CM) for 48h.
Control untreated monocyte (CD14+) sample
Untreated CD14+ monocytes from two different donors.

minimal change disease study 8 (glomerulus) / focal segmental glomerulosclerosis; minimal change disease study 5 (glomerulus)

Relative Expression (log2-ratio):2.1872225
Number of Samples:5 / 6
Experimental minimal change disease study 8 (glomerulus)
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from minimal change disease. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control focal segmental glomerulosclerosis; minimal change disease study 5 (glomerulus)
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis and minimal change disease. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.