TOP TEN perturbations for 1554574_a_at (Homo sapiens)

Organism: Homo sapiens
Gene: 1554574_a_at
Selected probe(set): 201885_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 1554574_a_at (201885_s_at) across 6622 perturbations tested by GENEVESTIGATOR:

sarcoidosis study 6 (orbital adipose tissue) / normal orbital adipose tissue

Relative Expression (log2-ratio):-2.420991
Number of Samples:7 / 22
Experimental sarcoidosis study 6 (orbital adipose tissue)
Orbital adipose tissue samples obtained from patients who suffered from sarcoidosis. Biopsies were formalin-fixed and paraffin-embedded.
Control normal orbital adipose tissue
Normal orbital adipose tissue samples. Samples were obtained from subjects with no history of orbital disease at the time of surgery such as fat typically excised and discarded as part of routine blepharoplasty or retrobulbar fat that is snared with the eye during enucleation. Biopsies were formalin-fixed and paraffin-embedded.

ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary) / ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-2.2940674
Number of Samples:2 / 2
Experimental ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary transitional cell carcinoma, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; clear cell adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the ovary (subcutaneously implanted).

glioma study 17 (anaplastic astrocytoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):2.285037
Number of Samples:2 / 3
Experimental glioma study 17 (anaplastic astrocytoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from high grade anaplastic astrocytoma (grade III). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 45 ± 18 years old.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

granulomatosis with polyangiitis study 3 (orbital adipose tissue) / normal orbital adipose tissue

Relative Expression (log2-ratio):-2.213994
Number of Samples:9 / 22
Experimental granulomatosis with polyangiitis study 3 (orbital adipose tissue)
Orbital adipose tissue samples obtained from patients who suffered from granulomatosis with polyangiitis (GPA). Biopsies were formalin-fixed and paraffin-embedded.
Control normal orbital adipose tissue
Normal orbital adipose tissue samples. Samples were obtained from subjects with no history of orbital disease at the time of surgery such as fat typically excised and discarded as part of routine blepharoplasty or retrobulbar fat that is snared with the eye during enucleation. Biopsies were formalin-fixed and paraffin-embedded.

nonspecific orbital inflammatory disease study 1 (orbital adipose tissue) / normal orbital adipose tissue

Relative Expression (log2-ratio):-2.070055
Number of Samples:31 / 22
Experimental nonspecific orbital inflammatory disease study 1 (orbital adipose tissue)
Orbital adipose tissue samples obtained from patients who suffered from nonspecific orbital inflammatory disease (NSOI). Biopsies were formalin-fixed and paraffin-embedded.
Control normal orbital adipose tissue
Normal orbital adipose tissue samples. Samples were obtained from subjects with no history of orbital disease at the time of surgery such as fat typically excised and discarded as part of routine blepharoplasty or retrobulbar fat that is snared with the eye during enucleation. Biopsies were formalin-fixed and paraffin-embedded.

ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary) / ovarian tumor study 30 (PDX; adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-1.9847975
Number of Samples:2 / 2
Experimental ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary transitional cell carcinoma, NOS of the ovary (subcutaneously implanted).
Control ovarian tumor study 30 (PDX; adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary adenocarcinoma, NOS of the ovary (subcutaneously implanted).

thyroid eye disease study 1 (orbital adipose tissue) / sarcoidosis study 6 (orbital adipose tissue)

Relative Expression (log2-ratio):1.8982725
Number of Samples:27 / 7
Experimental thyroid eye disease study 1 (orbital adipose tissue)
Orbital adipose tissue samples obtained from patients who suffered from thyroid eye disease (TED). Biopsies were formalin-fixed and paraffin-embedded.
Control sarcoidosis study 6 (orbital adipose tissue)
Orbital adipose tissue samples obtained from patients who suffered from sarcoidosis. Biopsies were formalin-fixed and paraffin-embedded.

WISP1 depletion study 1 / scrambled shRNA transfected MSC sample

Relative Expression (log2-ratio):-1.8546686
Number of Samples:3 / 3
Experimental WISP1 depletion study 1
Primary human mesenchymal stem cells (MSC) with shRNA mediated knockdown of WISP1. Targeting shRNA sequence (shRNA5: 5′-CCGGGCTTCTGTAACCTGAGCTGTACTCGAGTACAGCTCAGGTTACAGAAGCTTTTTG-3′) was integrated into the lentiviral vector pLKO.1 and total RNA was isolated on day four post-transduction. MSC were isolated from the femoral heads of trabecular bone obtained from middle to old age patients undergoing total hip arthroplasty. Cells were grown in growth medium containing 50 ug/ml of L-ascorbic acid 2-phosphate and trypsinized and passaged once for experimental settings.
Control scrambled shRNA transfected MSC sample
Primary human mesenchymal stem cells (MSC) expressing control (scrambled) shRNA. Transduced shRNA (5′-CCGGCCTAAGGTTAAGTCGCCCTCGCTCGAGCGAGGGCGACTTAACCTTAGGTTTTTG-3′) was integrated into the lentiviral vector pLKO.1 and total RNA was isolated on day four post-transduction. MSC were isolated from the femoral heads of trabecular bone obtained from middle to old age patients undergoing total hip arthroplasty. Cells were grown in growth medium containing 50 ug/ml of L-ascorbic acid 2-phosphate and trypsinized and passaged once for experimental settings.

breast cancer study 8 (metastatic) / normal breast tissue

Relative Expression (log2-ratio):-1.7922363
Number of Samples:2 / 4
Experimental breast cancer study 8 (metastatic)
Human metastatic infiltrating ductal carcinoma sample of the breast derived from lymph nodes of a female patient with breast cancer.
Control normal breast tissue
Normal human breast samples of healthy female individuals.

glioma study 17 (glioblastoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):1.7630548
Number of Samples:3 / 3
Experimental glioma study 17 (glioblastoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from high grade glioblastoma (grade IV). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 66 ± 5 years old males.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.