TOP TEN perturbations for 38398_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38398_at
Selected probe(set): 210252_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38398_at (210252_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
atopic dermatitis study 12 (lesional; adults) / atopic dermatitis study 12 (lesional; children)
Relative Expression (log2-ratio):1.7806902Number of Samples:20 / 18
Experimental | atopic dermatitis study 12 (lesional; adults) |
Lesional skin biopsy samples from adult patients (age range 18-73 years) with long-standing atopic dermatitis. | |
Control | atopic dermatitis study 12 (lesional; children) |
Lesional popliteal skin biopsy samples from pediatric patients (age range 3 months-5 years) with early-onset atopic dermatitis. All biopsy specimens were from chronic lesions present for more than 72 hours. All patients had moderate-to-severe disease with recent-onset (within the previous 6 months). Systemic immunosuppressants within the past 4 weeks, topical steroids or immunomodulators within 1 week, or moisturizers within 12 hours before evaluation were restricted. Patients with active skin infections were excluded. |
atopic dermatitis study 12 (non-lesional; adults) / atopic dermatitis study 12 (non-lesional; children)
Relative Expression (log2-ratio):1.6817627Number of Samples:20 / 19
Experimental | atopic dermatitis study 12 (non-lesional; adults) |
Unaffected skin biopsy samples from adult patients (age range 18-73 years) with long-standing atopic dermatitis. | |
Control | atopic dermatitis study 12 (non-lesional; children) |
Unaffected buttock skin biopsy samples from pediatric patients (age range 3 months-5 years) with early-onset atopic dermatitis. All patients had moderate-to-severe disease (SCORAD score: mean, 57.8; range, 33-84) with recent-onset (within the previous 6 months). Systemic immunosuppressants within the past 4 weeks, topical steroids or immunomodulators within 1 week, or moisturizers within 12 hours before evaluation were restricted. Patients with active skin infections were excluded. |
atypical teratoid/rhabdoid tumor study 1 / non-tumor brain tissue
Relative Expression (log2-ratio):-1.6365967Number of Samples:20 / 9
Experimental | atypical teratoid/rhabdoid tumor study 1 |
Primary tumor tissue sample from the brain of pediatric patients with atypical teratoid/rhabdoid tumor (AT/RT). | |
Control | non-tumor brain tissue |
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor. |
esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; metastatic) / esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; primary)
Relative Expression (log2-ratio):1.6030035Number of Samples:2 / 3
Experimental | esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; metastatic) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary squamous cell carcinoma, NOS of the oesophagus (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
Control | esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary squamous cell carcinoma, NOS of the oesophagus (subcutaneously implanted). |
glioma study 16 (LN-18) / normal astrocyte sample
Relative Expression (log2-ratio):1.5802374Number of Samples:2 / 3
Experimental | glioma study 16 (LN-18) |
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2. | |
Control | normal astrocyte sample |
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations. |
glioma study 5 / non-tumor brain tissue
Relative Expression (log2-ratio):-1.550417Number of Samples:12 / 9
Experimental | glioma study 5 |
Primary tumor tissue sample from the supratentorial brain of pediatric patients with glioblastoma multiformae. | |
Control | non-tumor brain tissue |
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor. |
HIV-associated neurocognitive disorder study 7 (normal) / HIV-associated neurocognitive disorder study 6 (normal)
Relative Expression (log2-ratio):1.5123272Number of Samples:2 / 2
Experimental | HIV-associated neurocognitive disorder study 7 (normal) |
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients received antiretroviral therapy (ART). | |
Control | HIV-associated neurocognitive disorder study 6 (normal) |
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients did not receive any antiretroviral therapy (ART). |
brain tumor study 1 (ependymoma) / normal brain tissue
Relative Expression (log2-ratio):-1.3858871Number of Samples:46 / 12
Experimental | brain tumor study 1 (ependymoma) |
Primary tumor tissue sample from the brain of patients with ependymoma. | |
Control | normal brain tissue |
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors. |
hCMV study 1 (CD69+) / uninfected CD4 T-LGL sample (diseased)
Relative Expression (log2-ratio):-1.3355455Number of Samples:4 / 3
Experimental | hCMV study 1 (CD69+) |
CD69+ human cytomegalovirus (hCMV)-stimulated monoclonal CD4+ T-large granular lymphocytes (T-LGL) from peripheral blood of patients with monoclonal T-cell receptor (TCR)-alphabeta(+)/CD4(+) T-large granular lymphocyte (LGL) lymphocytosis. | |
Control | uninfected CD4 T-LGL sample (diseased) |
Unstimulated monoclonal CD4+ T-large granular lymphocytes (T-LGL) from peripheral blood of patients with monoclonal T-cell receptor (TCR)-alphabeta(+)/CD4(+) T-large granular lymphocyte (LGL) lymphocytosis. |
brain tumor study 1 (glioblastoma) / normal brain tissue
Relative Expression (log2-ratio):-1.3233547Number of Samples:34 / 12
Experimental | brain tumor study 1 (glioblastoma) |
Primary tumor tissue sample from the brain of patients with glioblastoma multiformae. | |
Control | normal brain tissue |
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors. |