TOP TEN perturbations for 38457_at (Homo sapiens)

Organism: Homo sapiens
Gene: 38457_at
Selected probe(set): 206393_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 38457_at (206393_at) across 6674 perturbations tested by GENEVESTIGATOR:

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):7.1144915
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37°C in humidified air containing 5% CO2.

kidney transplantation study 9 (late) / normal kidney transplant

Relative Expression (log2-ratio):4.3175974
Number of Samples:2 / 13
Experimental kidney transplantation study 9 (late)
Human renal allograft biopsies from deceased donors obtained 24 months after transplantation.
Control normal kidney transplant
Human renal allograft biopsies from deceased donors obtained at implantation prior to revascularization.

embryonic development study 1 (9wk) / embryonic development study 1 (4wk)

Relative Expression (log2-ratio):3.3132782
Number of Samples:3 / 3
Experimental embryonic development study 1 (9wk)
Human embryos at 9th week after fertilization. Embryos were obtained after therapeutic termination of pregnancy with mifepristone.
Control embryonic development study 1 (4wk)
Human embryos at 4th week after fertilization. Embryos were obtained after therapeutic termination of pregnancy with mifepristone.

wound healing study 2 (ex vivo; AG1478) / normal skin tissue (ex vivo)

Relative Expression (log2-ratio):-3.016941
Number of Samples:3 / 3
Experimental wound healing study 2 (ex vivo; AG1478)
Ex vivo skin samples obtained from healthy donors following reduction surgery of abdomen, and incubated in culture medium containing AG1478 for 4 days. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. Skin was sliced into 1x10 mm slices and incubated in keratinocyte medium for four days with 10 micromolar AG1478 (dissolved in DMSO). The cultivation was performed in serum-free keratinocyte medium supplemented with transferrin, hEGF (0.15 ng/mL), 0.5 mg/mL hydrocortisone, gentamicin, amphotericin B, and epinephrine but without insulin. AG1478 is EGFR kinase inhibitor. ATC code:---
Control normal skin tissue (ex vivo)
Normal skin samples obtained from healthy donors following reduction surgery of abdomen. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection.

wound healing study 2 (ex vivo; DMSO) / normal skin tissue (ex vivo)

Relative Expression (log2-ratio):-2.9730864
Number of Samples:3 / 3
Experimental wound healing study 2 (ex vivo; DMSO)
Ex vivo skin samples obtained from healthy donors following reduction surgery of abdomen, and incubated in culture medium containing DMSO for 4 days. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. Skin was sliced into 1x10 mm slices and incubated in keratinocyte medium for four days with 1:1000 fold dilution of DMSO. The cultivation was performed in serum-free keratinocyte medium supplemented with transferrin, hEGF (0.15 ng/mL), 0.5 mg/mL hydrocortisone, gentamicin, amphotericin B, and epinephrine but without insulin.
Control normal skin tissue (ex vivo)
Normal skin samples obtained from healthy donors following reduction surgery of abdomen. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection.

L3.6pl / COLO 357/FG

Relative Expression (log2-ratio):-2.8843498
Number of Samples:3 / 3
Experimental L3.6pl
Human, xenograft derived, pancreatic carcinoma cell line with high metastatic potential. The cell line is derived from liver metastases formed in mouse xenograft model. The mouse was originally injected with L3.3 pancreatic carcinoma cell line. Parental cell line:: COLO 357 Synonyms:L3.6PL; L3_6PL; L3.6 pancreas-liver; Colo357L3.6pl Cellosaurus code:
Control COLO 357/FG
Human, xenograft derived, pancreatic carcinoma cell line with low metastatic potential. The cell line is derived from unknown metastatic site of mouse xenograft model. The mouse was originally injected with COLO357 human pancreatic adenocarcinoma cell line. Parental cell line:: COLO 357 Synonyms:FG; Colo 357 FG; COLO 357 Fast Growing; Colo 357/FG; Colo357FG; COLO357FG; FG/COLO357 Cellosaurus code:

rheumatoid arthritis study 27 / normal synovial membrane tissue

Relative Expression (log2-ratio):-2.7613087
Number of Samples:16 / 7
Experimental rheumatoid arthritis study 27
Synovial membrane samples from end-stage rheumatoid arthritis patients undergoing surgery.
Control normal synovial membrane tissue
Synovial membrane samples obtained by fine-needle arthroscopy from healthy subjects.

atopic dermatitis study 21 (lesional; epidermis) / normal epidermis tissue

Relative Expression (log2-ratio):-2.706643
Number of Samples:5 / 10
Experimental atopic dermatitis study 21 (lesional; epidermis)
Lesional epidermal samples isolated from patient with moderate-to-severe chronic atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal epidermis tissue
Epidermal samples isolated from healthy subjects by laser capture microdissection.

psoriasis study 20 (lesional) / psoriasis study 20 (non-lesional)

Relative Expression (log2-ratio):-2.6581821
Number of Samples:4 / 4
Experimental psoriasis study 20 (lesional)
Lesional skin punch biopsies derived from patients with chronic plaque psoriasis. 6 mm punch biopsies were obtained under local anesthesia preferentially near the central region of active plaques, except in cases where the center was poorly defined due to an irregular boundary. Regions near the edge of individual plaques were avoided to ensure that uninvolved skin was not included. Patients with one or more psoriasis plaques not limited to the scalp area were enrolled to the study. In case that only one plaque was present, a patient was admitted when that plaque occupied more than 1% of the body surface area. Patients were advised not to apply topical treatments for at least 1 week prior to biopsies and not to use systemic medications for at least 2 weeks prior to sample biopsies. Biopsies were snap-frozen in liquid nitrogen, stored at -80°C.
Control psoriasis study 20 (non-lesional)
Non-lesional skin punch biopsies derived from patients with chronic plaque psoriasis. 6 mm punch biopsies were obtained under local anesthesia from the buttocks and at least 10 cm away from the nearest active psoriasis plaque. Patients with one or more psoriasis plaques not limited to the scalp area were enrolled to the study. In case that only one plaque was present, a patient was admitted when that plaque occupied more than 1% of the body surface area. Patients were advised not to apply topical treatments for at least 1 week prior to biopsies and not to use systemic medications for at least 2 weeks prior to sample biopsies. Biopsies were snap-frozen in liquid nitrogen, stored at -80°C.

resorcinol study 1 (48h) / vehicle (EtOH) treated HepG2 cell sample

Relative Expression (log2-ratio):2.6503258
Number of Samples:3 / 6
Experimental resorcinol study 1 (48h)
HepG2 cells exposed to 2mM resorcinol in EtOH solvent for 48 hours. ATC code:,
Control vehicle (EtOH) treated HepG2 cell sample
HepG2 cells exposed to EtOH solvent for 48 hours.